2010
DOI: 10.1016/j.jss.2009.11.660
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Superior Myocardial Preservation with HTK Solution over Celsior in Rat Hearts with Prolonged Cold Ischemia

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Cited by 8 publications
(10 citation statements)
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“…(3) the presence of antioxidant tryptophan; (4) the presence of mannitol to reduced cell swelling; and (5) a high histidine (198 mmol/L) buffering to counter tissue acidosis during cold global ischemia. 20,34 In 2010, Lee and colleagues, 35 using a rat transplant model, reported superiority of Custodiol-HTK over Celsior on the basis of lower serum creatine kinase levels and less macroscopic deterioration of the graft after 6 or 18 hours of cold storage. However, no pump function was reported, and, as the authors acknowledged, these hearts were not loaded and cannot be extrapolated to clinical conditions.…”
Section: Celsior Versus Custodiol Histidine-tryptophan-ketoglutarate Preservation Solutionmentioning
confidence: 99%
“…(3) the presence of antioxidant tryptophan; (4) the presence of mannitol to reduced cell swelling; and (5) a high histidine (198 mmol/L) buffering to counter tissue acidosis during cold global ischemia. 20,34 In 2010, Lee and colleagues, 35 using a rat transplant model, reported superiority of Custodiol-HTK over Celsior on the basis of lower serum creatine kinase levels and less macroscopic deterioration of the graft after 6 or 18 hours of cold storage. However, no pump function was reported, and, as the authors acknowledged, these hearts were not loaded and cannot be extrapolated to clinical conditions.…”
Section: Celsior Versus Custodiol Histidine-tryptophan-ketoglutarate Preservation Solutionmentioning
confidence: 99%
“…Cellular adenosine triphosphate (ATP) level was quantitated using the ENLITEN ATP luciferin/luciferase bioluminescence assay system (Promega, Madison, WI, USA) as previously described [19,20].…”
Section: Methodsmentioning
confidence: 99%
“…There have been many studies comparing various storage solutions; a new "polarizing" solution [adenosine-lidocaine (Adenocaine) solution] developed by Rudd and Dobson (2009) showed improved post-storage recovery to Celsior V R after 6 h of storage. In vivo heart transplantation studies using hearts stored for 6 or 18 h prior to heterotopic transplantation (Lee et al 2010(Lee et al , 2011 showed superior protection with HTK solution compared with Celsior V R . In contrast, Celsior V R was shown to be associated with improved post-transplant recovery (cardiac output) together with lower vasculopathy and chronic rejection than in hearts preserved with Custodiol or Viaspan (Garlicki, 2003).…”
Section: Introductionmentioning
confidence: 99%