Superovulatory response and embryo quality in Katahdin ewes treated with FSH or FSH plus eCG during non-breeding season

Luna-Palomera, Carlos; Macías‐Cruz, Ulises; Sánchez-Dávila, Fernando

doi:10.1007/s11250-019-01801-9

Cited by 9 publications

(8 citation statements)

References 31 publications

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“…Similarly, De et al [ 20 ] obtained a 57.57% lambing rate during non-breeding seasons in subtropical Malpura and Kheri breeds. Moreover, several studies indicated the possible negative effects of eCG on embryo survival specifically during the pre-implantation period, either when used for in vivo [ 21 ] or in vitro [ 22 , 23 ] assisted reproductive techniques. For example, eCG of a dosage used for superovulation and, to a lesser degree, of a dosage used for estrus synchronization can affect glycosidase activity in the genital tract of the Chios breed of ewes before the maternal recognition of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Use of GnRH-Encapsulated Chitosan Nanoparticles as an Alternative to eCG for Induction of Estrus and Ovulation during Non-Breeding Season in Sheep

Hashem

El-Hawy

El-Bassiony

et al. 2023

Biology

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This study is aimed at determining the reproductive performance of anestrous ewes treated with nanoencapsulated GnRH after a progesterone-based protocol for estrus induction was proposed as a way of replacing eCG. A total of sixty anestrous, multiparous, non-lactating Barki ewes were randomly allocated into three homogenous groups and subjected to a CIDR-based estrus induction protocol. The first group (eCG) received an intramuscular (i.m.) injection of 350 IU of eCG at CIDR removal. The second (LNGnRH) and third (HLNGnR) groups received either 25 µg or 50 µg of encapsulated GnRH nanoparticles by the i.m. route in the form of spherical GnRH-encapsulated chitosan–TPP nanoparticles (which were 490.8 nm and had a 13.6 mV positive charge) 48 h after CIDR removal. Follicular dynamics, estrous behavior, luteal activity, and pregnancy outcomes were evaluated. Three days after CIDR removal, the number of large follicles increased by similar amounts in the LNGnRH and eCG groups and were significantly higher in both groups than in the HNGnRH group. However, no differences were observed in the numbers and diameters of CLs among the experimental groups and, on the other hand, treatment with HNGnRH significantly increased blood serum progesterone levels compared with eCG and LNGnRH. Treatment with HNGnRH increased conception, lambing, and fecundity rates (p < 0.05), with the trend of a higher litter size (p = 0.081) compared with eCG, whereas LNGnRH resulted in intermediate values. In conclusion, a dose of 50 µg of GnRH encapsulated in chitosan-TPP nanoparticles can be used as an alternative to eCG in progesterone-based estrus induction protocols in sheep.

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Section: Discussionmentioning

confidence: 99%

Use of GnRH-Encapsulated Chitosan Nanoparticles as an Alternative to eCG for Induction of Estrus and Ovulation during Non-Breeding Season in Sheep

Hashem

El-Hawy

El-Bassiony

et al. 2023

Biology

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“…Their results illustrated that GnRH administration, as a component of ovulation control protocols, resulted in a significant increase in conception, lambing, and fecundity rates with a tendency towards larger litter sizes compared to those treated with eCG. However, various studies have indicated potential adverse impacts of eCG on embryo survival, particularly during the pre-implantation stage, when utilizing either in vivo [ 134 ] or in vitro [ 135 , 136 ] techniques. For instance, in Chios-breed ewes, the use of eCG for superovulation, and, to a lesser extent, for estrus synchronization, can impact glycosidase activity in the genital tract, potentially leading to adverse effects on embryo survival and pregnancy maintenance before the maternal recognition of pregnancy [ 134 ].…”

Section: Application Of Exogenous Gnrh In Controlled Breedingmentioning

confidence: 99%

Application of Exogenous GnRH in Food Animal Production

Uddin

Petrovski

Song

et al. 2023

Animals

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Over several decades, exogenous GnRH and agonists have been employed for controlling reproductive cascades in animals, and treating some reproductive morbidities. The administration of GnRH is used in animals to counter ovarian dysfunction, induce ovulation, and to increase conception and pregnancy rates. GnRH and its agonists are used in the treatment of cystic ovarian degeneration and repeat breeder syndrome. The development of protocols for GnRH administration by intramuscular injection, intramuscular or subcutaneous implants, and intravaginal deposition has empowered their clinical use worldwide. Currently, exogenous GnRH products are a central part of several pre- and post-breeding programs for the enhancement of fertility, including the control of estrous cycles and timing of ovulation, development of fixed-time artificial insemination protocols, improved embryo survival, and the treatment of reproductive morbidity. The aim of the present review is to summarize the application of exogenous GnRH agonists in food animal production.

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“…The main factor of donors' response to superovulation is gonadotropin, which directly affects embryos recovery number from one donor (Pérez-Sandoval et al, 2019). Anterior pituitary gland produces FSH preparations and also it contains other biologically active substances such as LH, the amount of FSH and LH and their activity may vary depending on animal breed and different preparations (Braileanu et al, 1998;Ciornei et al, 2022;Donaldson et al, 1986;Luna-Palomera et al, 2019). In our present study, two follicle-stimulating preparations (Folltropin-V and FSH-P) were used to stimulate superovulation in Charolais and Ile-de-France ewes.…”

Section: Ta B L Ementioning

confidence: 99%

Embryo production and transplantation in non‐breeding season of meat sheep breeds by stimulating superovulation with different follicle‐stimulating hormone preparations

Aybazov

Selionova

Trukhachev

et al. 2022

Reprod Domestic Animals

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The objective of this study was to investigate the response of Charolais and Ile-de-France meat sheep breeds to stimulate superovulation with various follicle-stimulating hormone (FSH) preparations. A total of 14 adult ewes of meat sheep breeds were used in our study as donors, including Charolais breed (n = 8) and Ile-de-France breed (n = 6). Donors ewes were randomly divided into two groups in equal numbers (first group, n = 7; second group, n = 7), every group included Charolais breed (n = 4) and Ile-de-France breed (n = 3). Ewes in the first group were treated with Folltropin-V (total dose of 200 mg per ewe, seven injections), and ewes in the second group were treated with FSH-P (total of 280 IU per ewe, six injections). Thirty-seven ewes of Edilbay breed used as recipients were divided into two groups (first group, n = 20; second group, n = 17). Our results showed that the number of corpora lutea in donor groups treated with Folltropin-V was significantly higher than in donor groups treated with FSH-P (p < .01). A greater number of embryos recovery and embryos suitable for transplantation were found in the first group compared with the second group of donors. After 30 days from transplantation, transabdominal ultrasonography showed that the presence of pregnancy in recipients groups was found in 16 recipient ewes (43.2%), in the first group of recipients were registered nine pregnant ewes of 20 recipient ewes (45.0%), and in the second group of recipients were registered seven pregnant ewes of 17 recipient ewes (41.2%). In conclusion, using Folltropin-V in Charolais and Ile-de-France meat sheep breeds is a more effective scheme for stimulating superovulation than using FSH-P.

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Superovulatory response and embryo quality in Katahdin ewes treated with FSH or FSH plus eCG during non-breeding season

Cited by 9 publications

References 31 publications

Use of GnRH-Encapsulated Chitosan Nanoparticles as an Alternative to eCG for Induction of Estrus and Ovulation during Non-Breeding Season in Sheep

Use of GnRH-Encapsulated Chitosan Nanoparticles as an Alternative to eCG for Induction of Estrus and Ovulation during Non-Breeding Season in Sheep

Application of Exogenous GnRH in Food Animal Production

Embryo production and transplantation in non‐breeding season of meat sheep breeds by stimulating superovulation with different follicle‐stimulating hormone preparations

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