Superoxide Dismutase: A Role in the Prevention ofChronic Lung Disease

Davis, Jonathan M.

doi:10.1159/000047032

Cited by 25 publications

(7 citation statements)

References 26 publications

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“…However, preterm experimental animals and presumably newborn infants as well have deficient endogenous AOE activity and limited capacity to augment their levels of protective AOEs during oxygen exposure to overcome oxidative stress (7,8). Studies have established positive correlations between relative resistance to hyperoxia and increase of some or all of the pulmonary AOEs in newborn animals and humans (22,23). Bucher et al demonstrated a significant increase in GPX and SOD but not in CAT activity in newborn rats exposed to O 2 >95% for 6 d and in all three AOEs when exposed for 12 d (2).…”

Section: Discussionmentioning

confidence: 99%

Pentoxifylline and prevention of hyperoxia-induced lung injury in neonatal rats

Almario

Peng

et al. 2012

Pediatr Res

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IntroductIon:Oxygen exposure plays an important role in the pathogenesis of bronchopulmonary dysplasia (BPD). The phosphodiesterase inhibitor pentoxifylline (PTX) has antiinflammatory and antifibrotic effects in multiple organs. It was hypothesized that PTX would have a protective effect on hyperoxia-induced lung injury (hILI). Methods: Newborn sprague-Dawley rats were exposed to >95% oxygen (O 2 ) and injected subcutaneously with normal saline (Ns) or PTX (75 mg/kg) twice a day for 9 d. Ns-injected, room air-exposed pups were controls. at days 4 and 9, lung tissue was collected to assess edema, antioxidant enzyme (aOe) activities, and vascular endothelial growth factor (VeGF) expression. at day 9, pulmonary macrophage infiltration, vascularization, and alveolarization were also examined. results: at day 9, treatment with PTX significantly increased survival from 54% to 88% during hyperoxia. Treatment with PTX significantly decreased lung edema and macrophage infiltration. PTX treatment increased lung aOe activities including those of superoxide dismutase (sOD), catalase (caT), and glutathione peroxidase (GPX). Furthermore, PTX treatment also increased the gene expression of VeGF189 and VeGF165, increased VeGF protein expression, and improved pulmonary vascularization. dIscussIon: These data indicate that the reduced lung edema and inflammation, increased aOe activities, and improved vascularization may be responsible for the improved survival with PTX during hyperoxia. PTX may be a potential therapy in reducing some of the features of BPD in preterm newborns.

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Section: Discussionmentioning

confidence: 99%

Pentoxifylline and prevention of hyperoxia-induced lung injury in neonatal rats

Almario

Peng

et al. 2012

Pediatr Res

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“…high-frequency ventilation [22], patient-triggered ventilation, pressure-support/volume guarantee, assist-control/volume guarantee, synchronized intermittent mandatory ventilation and assist-control ventilation [23], proportional assisted ventilation [24], surfactant administration [25], delivery of oxygen radical scavengers, i.e. superoxide dismutase [26,27], protease inhibitors, i.e. alpha-1-proteinase [28,29], as well as current investigation of agents with anti-inflammatory potential, i.e.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Tidal Liquid Ventilation in Premature Lambs: Physiologic, Biochemical and Histological Correlates

Cox¹,

Stavis²,

Wolfson³

et al. 2003

Neonatology

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Chronic lung disease in infants continues to be problematic. Tidal liquid ventilation (TLV) improves lung mechanics and provides effective gas exchange. We hypothesized that premature lambs could be supported safely with TLV and evaluated 9 preterm lambs (132 days gestation) on TLV up to 72 h. Results (mean ± SEM): pH 7.36 ± 0.003, Pa_CO2 44 ± 0.34 mm Hg, Pa_O2 170 ± 4.8 mm Hg, compliance = 1.65 ± 0.24 ml/cm H₂O/kg, mean arterial blood pressure = 53 ± 0.08 mm Hg, heart rate = 189 ± 1.5 bpm. Blood perflubron levels were 6.0 ± 0.24 µg/ml over 24 h. Tissue perflubron levels increased from 81 ± 7.0 µg/g at 24 h to 108 ± 15 µg/g at 72 h (p < 0.05). There was a difference in perflubron concentrations as a function of tissue (p < 0.001) that correlated to lipid levels (r² = 0.93, p < 0.01). These data demonstrate that TLV is both safe and effective up to 72 h in premature lambs.

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“…A instilação intratraqueal de enzimas antioxi dantes, como a superóxido-dismutase, mostrou algum benefício no animal [74][75][76] . No humano, os estudos de Davis e colaboradores [77][78] (instilação intratraqueal de 2,5 ou 5 mg/kg de superóxido-dismutase recombinante, após a administração de surfactante e cada 48 horas enquanto intubados, até sete doses) não demonstraram diminuição da incidência de displasia broncopulmonar, mas demonstraram diminuição da incidência de pieira, número de internamentos e necessidade de medicação respiratória aos 12 meses de vida. A utilização de eritropioetina (administração subcutânea de 400 U ou 800 U de eritropioetina recombinante, nos dias zero e dois de vida, no coelho de pré-termo exposto a oxigénio a 100%), ao fixar o ferro livre plasmático, inibe os seus efeitos tóxicos directos, nomeadamente a peroxidação lipídica 81 .…”

Section: Terapêuticaunclassified

Stress oxidativo na lesão pulmonar neonatal

Rocha

2008

Revista Portuguesa de Pneumologia (English Edition)

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Artigo de Revisão Revision Article Resumo O stress oxidativo é um dos factores de risco para o desenvolvimento de displasia broncopulmonar no recém-nascido de pré-termo. Este apresenta deficiente defesa antioxidante. Por outro lado, o stress oxidativo também tem papel no crescimento e desenvolvimento celular. A relação entre stress oxidativo e crescimento celular necessita de ser melhor conhecida antes da introdução de terapêuticas antioxidantes. Várias terapêuticas antioxidantes têm sido tentadas, até ao momento sem êxito. Neste artigo é feita uma revisão da evidência do papel dos radicais livres de oxigénio na displasia broncopulmonar.

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Superoxide Dismutase: A Role in the Prevention ofChronic Lung Disease

Cited by 25 publications

References 26 publications

Pentoxifylline and prevention of hyperoxia-induced lung injury in neonatal rats

Pentoxifylline and prevention of hyperoxia-induced lung injury in neonatal rats

Long-Term Tidal Liquid Ventilation in Premature Lambs: Physiologic, Biochemical and Histological Correlates

Stress oxidativo na lesão pulmonar neonatal

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Superoxide Dismutase: A Role in the Prevention ofChronic Lung Disease

Cited by 25 publications

References 26 publications

Pentoxifylline and prevention of hyperoxia-induced lung ­injury in neonatal rats

Pentoxifylline and prevention of hyperoxia-induced lung ­injury in neonatal rats

Long-Term Tidal Liquid Ventilation in Premature Lambs: Physiologic, Biochemical and Histological Correlates

Stress oxidativo na lesão pulmonar neonatal

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Product

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Pentoxifylline and prevention of hyperoxia-induced lung injury in neonatal rats

Pentoxifylline and prevention of hyperoxia-induced lung injury in neonatal rats