Superoxide Dismutase Isoenzyme Activities in Plasma and Tissues of Iraqi Patients with Breast Cancer

Hasan, Hathama Razooki; Mathkor, Thikra Hasan; Al-Habal, Mohammed Hasan

doi:10.7314/apjcp.2012.13.6.2571

Cited by 12 publications

(12 citation statements)

References 60 publications

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“…Another study by Hasan et al, assessed SOD activities in plasma and tissues of BC patients. Their results indicated that SOD activity was increased in BC patients (Hasan, Mathkor, & Al‐Habal, ). Several studies suggested the value of thiol and catalase as an antioxidant which can be used for monitoring of response to therapy in BC patients (Davison et al, ; Kedzierska et al, ).…”

Section: Discussionmentioning

confidence: 98%

RETRACTED: PNU‐74654 enhances the antiproliferative effects of 5‐FU in breast cancer and antagonizes thrombin‐induced cell growth via the Wnt pathway

Rahmani

Amerizadeh

Hassanian

et al. 2019

Journal Cellular Physiology

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The Wnt/β‐catenin pathway is one of the most common pathways dysregulated in breast cancer, and may, therefore, be a potential‐therapeutic target. We have investigated the effects of PNU‐74654 in breast cancer, as a Wnt/β‐catenin inhibitor, either alone or in combination with fluorouracil (5‐FU). PNU‐74654 suppressed cell growth at an IC 50 of 122 ± 0.4 μmol/L and synergistically enhanced the antiproliferative activity of gemcitabine by modulating the Wnt pathway. Using a 3D cell culture model, we found that the PNU‐74654 caused tumor shrinkage. It reduced the migration of MCF‐7 cells (by an 18% reduction in invasive behavior) after the treatment with PNU‐74654 through perturbation of E‐cadherin and MMP3/9. PNU‐74654/5‐FU combination enhanced the percentages of cells in S‐phase and significantly increased apoptosis. Moreover, our data showed that this agent was able to inhibit the growth of tumor in a xenograft model, although this effect was more pronounced in the animals treated with PNU‐74654 plus 5‐FU. These data show the ability of PNU‐74654 to specifically target Wnt pathway, interfere with cell proliferation, induce‐apoptosis, reduce‐migration, and synergistically interact with 5‐FU, supporting further studies on this novel therapeutic‐approach for breast cancer.

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Section: Discussionmentioning

confidence: 98%

RETRACTED: PNU‐74654 enhances the antiproliferative effects of 5‐FU in breast cancer and antagonizes thrombin‐induced cell growth via the Wnt pathway

Rahmani

Amerizadeh

Hassanian

et al. 2019

Journal Cellular Physiology

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“…In the present study, the oxidative stress level was improved marginally following surgical treatment, and was positively affected by physical activities, but in different ways in the two survivor groups who undertook training programs. Enzymatic and non-enzymatic antioxidants, as well as lipid peroxidation, have been reported to be altered among various tissues types and individual breast cancer patients (32,33). In the present study, in the presence of elevated levels of ROS (based on the d-ROMs test), high levels of LPO levels were observed following physical training.…”

Section: Discussionsupporting

confidence: 47%

Effects of physical activity on systemic oxidative/DNA status in breast cancer survivors

et al. 2016

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Abstract. Physical activity offers a paradoxical hormetic effect and a health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in breast cancer, the association between health benefits and redox status has not been investigated in survivors who participate in dragon boating. The present study investigated the plasmatic systemic oxidative status (SOS) in breast cancer survivors involved in two distinct physical training exercises. A total of 75 breast cancer survivors were allocated to one of three groups: Control (resting), dragon boat racing and walking group; the latter is a type of aerobic conditioning exercise often advised to cancer patients. �arious biochemical oxida-. �arious biochemical oxidative stress markers were examined, including oxidant status (hydroperoxide levels, lipid oxidation) and antioxidant status (enzymatic activities of superoxide dismutase and glutathione peroxidase, reduced glutathione levels and antioxidant capability). In addition, the individual DNA fragmentation and DNA repair capability of nucleotide excision repair (NER) systems were examined by comet assays. According to the results, all patients exhibited high levels of oxidative stress. Physical activity maintained this oxidative stress condition but simultaneously had a positive influence on the antioxidant component of the SOS, particularly in the dragon boat racing group. DNA fragmentation, according to the levels of singleand double-strand breaks, were within the normal range in the two survivor groups that were involved in training activities. Radiation-induced damage was not completely recognised or repaired by NER systems in any of the patients, probably leading to radiosensitivity and/or susceptibility of patients to cancer. These findings suggest that physical activity, particularly dragon boat racing, that modulates SOS and DNA repair capability could represent a strategy for enhancing the quality of life and improving the long-term health benefits for breast cancer survivors.

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“…In a previous study, we showed that elevated total superoxide dismutase might reflect a response to oxidative stress, and may predict a state of excess reactive oxidative species in carcinogenesis process, consequently may result in a reduction of 5´-NT activities in tissues of breast cancer women [28]. Our results agree with Durak et al, results which showed a lower adenosine deaminase & 5´-NT activities in cancerous tissues than those in corresponding non-cancerous human laryngeal tissues [29].…”

Section: Discussionsupporting

confidence: 82%

Evaluation of tissue 5´-Nucleotidase as tumor marker in breast and brain tumors using receiver operating characteristic curve

Hr¹,

Th²,

Me³

2013

J Cancer Res Ther

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Superoxide Dismutase Isoenzyme Activities in Plasma and Tissues of Iraqi Patients with Breast Cancer

Cited by 12 publications

References 60 publications

RETRACTED: PNU‐74654 enhances the antiproliferative effects of 5‐FU in breast cancer and antagonizes thrombin‐induced cell growth via the Wnt pathway

RETRACTED: PNU‐74654 enhances the antiproliferative effects of 5‐FU in breast cancer and antagonizes thrombin‐induced cell growth via the Wnt pathway

Effects of physical activity on systemic oxidative/DNA status in breast cancer survivors

Evaluation of tissue 5´-Nucleotidase as tumor marker in breast and brain tumors using receiver operating characteristic curve

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