2012
DOI: 10.1016/j.yjmcc.2012.02.007
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Superoxide flashes: Elemental events of mitochondrial ROS signaling in the heart

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Cited by 56 publications
(50 citation statements)
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References 87 publications
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“…We previously demonstrated that mt-cpYFP flash events are coincident with a sustained loss of the fluorescence of rhod-2 or a Ca 2ϩ -insensitive rhod-2 analog in cardiac myocytes (1,19). Similar results are also observed during flash activity in FDB fibers in which mitochondria were loaded with mag-rhod-2 (Fig.…”
Section: Bimodal Dependence Of Flash Frequency On Inner Mitochondrialsupporting
confidence: 73%
“…We previously demonstrated that mt-cpYFP flash events are coincident with a sustained loss of the fluorescence of rhod-2 or a Ca 2ϩ -insensitive rhod-2 analog in cardiac myocytes (1,19). Similar results are also observed during flash activity in FDB fibers in which mitochondria were loaded with mag-rhod-2 (Fig.…”
Section: Bimodal Dependence Of Flash Frequency On Inner Mitochondrialsupporting
confidence: 73%
“…In view of the obtained results, fucoidan prevented H9c2 from oxidative damage; further investigations were focused on the underlying mechanisms. The balance between ROS production and removal of excess ROS is essential in maintaining the redox state and homeostasis balance in the cell (Wang et al, 2012). At the subcellular level, increased ROS level can cause damage to nucleic acids and proteins leading to apoptosis (Lee et al, 2013;Qin et al, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Mitoflash represents a new form of mitochondrial functional and signaling activity Wang et al, 2008Wang et al, , 2012. We and others have shown that mitoflash generation is functionally and mechanically interlinked with mitochondrial ETC activity.…”
Section: Regulation Of Mitoflash Activity By Rsc Formationmentioning
confidence: 99%