Superparamagnetic iron oxide--enhanced versus gadolinium-enhanced MR imaging for differential diagnosis of focal liver lesions.

Vogl, Thomas J.; Hammerstingl, R; Schwarz, W.; Mack, Martin G.; Müller, P.; Pegios, W.; Keck, H.; Eibl-Eibesfeldt, A; Hoelzl, J; Woessmer, B; Bergman, Clifford; Félix, R.

doi:10.1148/radiology.198.3.8628887

Cited by 179 publications

(86 citation statements)

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“…For instance, Kupffer cells loaded by nanoparticles migrate through normal liver tissue and cause hypointense signal on T2-weighted images, whereas due to the lack of Kupffer cells in the tumor, malignant regions retain their original intensity and can be easily distinguished. 5,52 In the case of liver lesion induced by O. felineus, the same situation occurs. The damaged liver zones, formed predominantly around bile ducts, did not accumulated nanoparticles.…”

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confidence: 82%

3-Aminopropylsilane-modified iron oxide nanoparticles for contrast-enhanced magnetic resonance imaging of liver lesions induced by <em>Opisthorchis felineus</em>

Demin¹,

Pershina²,

Ivanov³

et al. 2016

IJN

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Purpose Liver fluke causes severe liver damage in an infected human. However, the infection often remains neglected due to the lack of pathognomonic signs. Nanoparticle-enhanced magnetic resonance imaging (MRI) offers a promising technique for detecting liver lesions induced by parasites. Materials and methods Surface modification of iron oxide nanoparticles produced by coprecipitation from a solution of Fe 3+ and Fe 2+ salts using 3-aminopropylsilane (APS) was carried out. The APS-modified nanoparticles were characterized by transmission electron microscopy, fourier transform infrared spectroscopy, and thermogravimetric analysis. Magnetic resonance properties of MNPs were investigated in vitro and in vivo. Results The amount of APS grafted on the surface of nanoparticles (0.60±0.06 mmol g −1 ) was calculated based on elemental analysis and infrared spectroscopy data. According to transmission electron microscopy data, there were no essential changes in the structure of nanoparticles during the modification. The APS-modified nanoparticles exhibit high magnetic properties; the calculated relaxivity r 2 was 271 mmol −1 s −1 . To obtain suspension with optimal hydrodynamic characteristics, amino groups on the surface of nanoparticles were converted into an ionic form with HCl. Cellular uptake of modified nanoparticles by rat hepatoma cells and human monocytes in vitro was 74.1±4.5 and 10.0±3.7 pg [Fe] per cell, respectively. Low cytotoxicity of the nanoparticles was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Annexin V/7-aminoactinomycin D flow cytometry assays. For the first time, magnetic nanoparticles were applied for contrast-enhanced MRI of liver lesions induced by Opisthorchis felineus . Conclusion The synthesized APS-modified iron oxide nanoparticles showed high efficiency as an MRI contrast agent for the evaluation of opisthorchiasis-related liver damage.

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confidence: 82%

3-Aminopropylsilane-modified iron oxide nanoparticles for contrast-enhanced magnetic resonance imaging of liver lesions induced by <em>Opisthorchis felineus</em>

Demin¹,

Pershina²,

Ivanov³

et al. 2016

IJN

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“…Further, the absence of Kupffer cells in malignancies has been exploited to allow for enhanced accuracy in discerning between healthy and diseased tissue through SPIO endowed contrast. 117,133,149 In addition to the detection and characterization of liver lesions, larger nanoparticles such as SHU555A and AMI-25 have also been shown capable of detecting focal splenic tumors. 5,157,160 Reimer et al, in imaging hepatic lesions, clearly show the power of enhanced detection through the use of SPIO, 117 ( Fig.…”

Section: Liver and Splenic Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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Abstract-The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance contrast, allowing researchers to monitor not only anatomical changes, but physiological and molecular changes as well. Applications have ranged from detecting inflammatory diseases via the accumulation of non-targeted SPIO in infiltrating macrophages to the specific identification of cell surface markers expressed on tumors. In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.

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“…Several authors have reported the presence of Kupffer cells in HCCs, especially in wHCC, but these can be confused with benign nodules in SPIO-enhanced MRI [2,4]. The characterisation of focal liver lesions by means of PSIL is considered problematic because the PSILs from several lesion types show an overlap [7,[11][12][13]. In particular, some studies reported an overlap between the PSILs of benign lesions and those of wHCC [7,11,13].…”

Section: Discussionmentioning

confidence: 99%

Percentage of signal intensity loss for characterisation of focal liver lesions in patients with chronic liver disease using ferucarbotran-enhanced MRI

Ct¹,

Rc²,

Chen³

et al. 2010

BJR

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ABSTRACT. The purpose of this study was to determine the percentage of signal intensity loss (PSIL) threshold for the characterisation of focal liver lesions among patients with chronic liver disease. 55 nodules in 49 patients with chronic liver disease who underwent ferucarbotran-enhanced MR studies were included. Among the 49 patients, 40 had liver cirrhosis and 9 had chronic hepatitis. 8 haemangiomas, 3 focal nodular hyperplasia, 9 dysplastic nodules and 12 well, 19 moderately and 4 poorly differentiated hepatocellular carcinomas (HCCs) were revealed. The PSIL, signal-to-noise ratio and contrast-to-noise ratio of each lesion type were calculated. The diagnostic performance of PSIL on ferucarbotran-enhanced T 2 weighted images (PSIL T2WI ) and T 2 weighted fat-suppression images (PSIL FS-T2WI ) that characterised hepatic tumours was compared with receiver operating characteristic (ROC) analysis. Using ROC analysis, the diagnostic performance of PSIL FS-T2WI was superior to that of PSIL T2WI (p50.01). The mean PSIL FS-T2WI of the benign lesions was significantly higher than that of HCC (p,0.001), and the mean PSIL FS-T2WI of well-differentiated HCC was significantly higher than that of moderately/poorly differentiated HCCs (p50.001). With a PSIL FS-T2WI threshold of 40% in lesions characterising ferucarbotran-enhanced FS-T2WI, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 88.6%, 95%, 90.9%, 96.9% and 82.6%, respectively. In conclusion, with ferucarbotran-enhanced FS-T2WI, a PSIL FS-T2WI threshold of 40% for characterising focal liver nodules among patients with chronic liver disease is recommended. It is useful for distinguishing HCC from benign nodules.

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Superparamagnetic iron oxide--enhanced versus gadolinium-enhanced MR imaging for differential diagnosis of focal liver lesions.

Abstract: AMI-25 decreased the SI of benign tumors and helped differentiate benign from malignant tumors.

Cited by 179 publications

References 0 publications

3-Aminopropylsilane-modified iron oxide nanoparticles for contrast-enhanced magnetic resonance imaging of liver lesions induced by <em>Opisthorchis felineus</em>

3-Aminopropylsilane-modified iron oxide nanoparticles for contrast-enhanced magnetic resonance imaging of liver lesions induced by <em>Opisthorchis felineus</em>

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Percentage of signal intensity loss for characterisation of focal liver lesions in patients with chronic liver disease using ferucarbotran-enhanced MRI

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