Superparamagnetic iron oxide magnetic nanomaterial-labeled bone marrow mesenchymal stem cells for rat liver repair after hepatectomy

Zhao, Shiyu; Wang, Yulin; Gao, Chengshun; Zhang, Jing; Bao, Hanying; Wang, Zhongyu; Gong, Peng

doi:10.1016/j.jss.2014.03.064

Cited by 21 publications

(18 citation statements)

References 36 publications

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“…Serum activities of ALT and AST significantly declined following MSCs therapy. These results are in agreement with those of Zhao et al 19 Time course MRI was adopted to confirm the homing of MSCs to the injured liver, and to document their therapeutic effects by correlating the radiologic findings to the hepatic pathology. Figure 5 follows the labeled MSCs into the injured liver by MRI.…”

Section: Discussionsupporting

confidence: 88%

“…The results also agree with those of Zhao et al, who transplanted SPION labeled MSCs via the rat tail vein and the portal vein into fibrotic rat livers, then visualized them by MRI. 19 In this work, MSCs injection improved hepatic pathology as depicted by the diminishing cirrhosis and the signs of recovery in the affected liver. These findings agree with those of Abdel Aziz et al and Zhao et al 13,19 The biochemical, molecular and radiologic findings confirmed the recovery of the injured liver.…”

Section: Discussionmentioning

confidence: 54%

“…19 In this work, MSCs injection improved hepatic pathology as depicted by the diminishing cirrhosis and the signs of recovery in the affected liver. These findings agree with those of Abdel Aziz et al and Zhao et al 13,19 The biochemical, molecular and radiologic findings confirmed the recovery of the injured liver. The mean serum level of α-fetoprotein showed a significant decline in the animals that received MSCs therapy compared The expression of these genes was assessed by real-time polymerase chain reaction.…”

Section: Discussionmentioning

confidence: 54%

“…The results also agree with those of Zhao et al, who used MRI to confirm that SPION-labeled MSCs colonized the liver. 19 They concluded that in vivo MRI of SPIONlabeled MSCs can be used to trace real-time liver healing during clinical treatment following hepatectomy. However, they did not use the MSCs to treat cirrhosis or HCC.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Mesenchymal stem cell therapy of hepatocellular carcinoma in rats: Detection of cell homing and tumor mass by magnetic resonance imaging using iron oxide nanoparticles

Faidah¹,

Noorwali²,

Atta³

et al. 2017

Adv Clin Exp Med

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Mesenchymal stem cell therapy of hepatocellular carcinoma in rats: Detection of cell homing and tumor mass by magnetic resonance imaging using iron oxide nanoparticles

Faidah¹,

Noorwali²,

Atta³

et al. 2017

Adv Clin Exp Med

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“…They concluded that transplanting cells via liver or spleen injection could effectively accelerate liver healing. In vivo MRI of SPIO‐labeled cells are propitious to trace real‐time liver healing during clinical treatment after hepatectomy …”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

Current investigations into magnetic nanoparticles for biomedical applications

Jiang

Aifantis

et al. 2016

J Biomedical Materials Res

282

166

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It is generally recognized that nanoparticles possess unique physicochemical properties that are largely different from those of conventional materials, specifically the electromagnetic properties of magnetic nanoparticles (MNPs). These properties have attracted many researchers to launch investigations into their potential biomedical applications, which have been reviewed in this article. First, common types of MNPs were briefly introduced. Then, the biomedical applications of MNPs were reviewed in seven parts: magnetic resonance imaging (MRI), cancer therapy, the delivery of drugs and genes, bone and dental repair, tissue engineering, biosensors, and in other aspects, which indicated that MNPs possess great potentials for many kinds of biomedical applications due to their unique properties. Although lots of achievements have been obtained, there is still a lot of work to do. New synthesis techniques and methods are still needed to develop the MNPs with satisfactory biocompatibility. More effective methods need to be exploited to prepare MNPs-based composites with fine microstructures and high biomedical performances. Other promising research points include the development of more appropriate techniques of experiments both in vitro and in vivo to detect and analyze the biocompatibility and cytotoxicity of MNPs and understand the possible influencing mechanism of the two properties. More comprehensive investigations into the diagnostic and therapeutic applications of composites containing MNPs with "core-shell" structure and deeper understanding and further study into the properties of MNPs to reveal their new biomedical applications, are also described in the conclusion and perspectives part.

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Iron Oxide Nanoparticle-Based MRI Contrast Agents: Characterization and In Vivo Use

Herranz

Morales

Rodríguez

et al. 2016

Magnetic Characterization Techniques for Nanomaterials

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Superparamagnetic iron oxide magnetic nanomaterial-labeled bone marrow mesenchymal stem cells for rat liver repair after hepatectomy

Cited by 21 publications

References 36 publications

Mesenchymal stem cell therapy of hepatocellular carcinoma in rats: Detection of cell homing and tumor mass by magnetic resonance imaging using iron oxide nanoparticles

Mesenchymal stem cell therapy of hepatocellular carcinoma in rats: Detection of cell homing and tumor mass by magnetic resonance imaging using iron oxide nanoparticles

Current investigations into magnetic nanoparticles for biomedical applications

Iron Oxide Nanoparticle-Based MRI Contrast Agents: Characterization and In Vivo Use

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