Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications

Qiao, Ruirui; Yang, Chunhui; Gao, Mingyuan

doi:10.1039/b902394a

Cited by 639 publications

(490 citation statements)

References 175 publications

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“…[378] In situ coating process is mainly used in synthesis approaches which lead to surface free nanoparticles in water. [379] That would subsequently result in the formation of magnetic cores and the coatings at the same time that uniformly encapsulates the NP core. However, this strategy may have some negative effects on the magnetic susceptibility of MNPs by limiting their crystallinity.…”

Section: Coatings Approaches Of Mnpsmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Coatings Approaches Of Mnpsmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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show abstract

“…[7][8][9] NPs, as is well known, exhibit properties that can be tremendously distinct from their macroscopic counterparts, 10 and the properties as well as surface chemistry then show strong sensitivity to particle size and shape. 11,12 The size-dependent properties can originate from the high surface-to-volume ratio, and influences by particle shapes can be attributed to the distinct crystallographic surfaces that enclose the NP.…”

Section: Introductionmentioning

confidence: 99%

Preparation of tunable-sized iron nanoparticles based on magnetic manipulation in inert gas condensation (IGC)

Xing

Brink

Kooi

et al. 2017

Journal of Applied Physics

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Iron nanoparticles (NPs) prepared by inert gas condensation were studied using high resolution transmission electron microscopy and Wulff construction shape analysis. The NP size and shape show strong dependence on the magnetic field above the target surface. The effect of the magnetic field could be tuned by adjusting the thickness of the protective backing plate positioned in-between the target and the magnetron head. With increasing backing plate thickness, the particle size decreases and the NP morphologies evolve from faceted to close-to-spherical polyhedral shapes. Moreover, with changes in size and shape, the particle structure also varies so that the NPs exhibit: (i) a core-shell structure for the faceted NPs with size ∼15–24 nm; (ii) a core-shell structure for the close-to-spherical NPs with size ∼8–15 nm; and (iii) a fully oxidized uniform structure for NPs with sizes less than ∼8 nm having a void in the center due to the Kirkendall effect. The decrease of NP size with the increasing backing plate thickness can be attributed to a reduced magnetic field strength above the iron target surface combined with a reduced magnetic field confinement. These results pave the way to drastically control the NP size and shape in a simple manner without any other adjustment of the aggregation volume within the deposition system.

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“…These kinds of nanoparticles have been successfully used and applied in magnetic recorders (Laurent et al 2008;Ghandoor et al 2012), cancer therapy (He et al 2008;Figuerola et al 2010) storing information processes (Yan et al 2009), magnetic resonance imaging (MRI) (Qiao et al 2009), and drug targeting (Figuerola et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Among the various magnetic nanoparticles, Fe 3 O 4 the nanoparticle has leading properties such as chemical stability, high dispersion in liquid circumferences, good bio-adaptability, stability in various physiological conditions and low dissolubility (Yan et al 2009;Tartaj et al 2003;Qiao et al 2009;Ghandoor et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Influence of carbon nanotubes support on the morphology of Fe3O4 nanoparticles

et al. 2014

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In this paper, the effects of carbon nanotubes as a support to the morphology and size of Fe 3 O 4 magnetic nanoparticles have been investigated. The synthesis of Fe 3 O 4 /CNTs nanocomposite powder was performed by the direct precipitation method through ferric chloride (II) and (III) at room temperature. The prepared samples were analyzed by X-ray diffraction spectra, Fourier transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. The results demonstrated considerable changes in the Fe 3 O 4 nanoparticle size, also the morphology of Fe 3 O 4 /CNTs nanocomposite powder from agglomerative into rode shape.

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Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications

Cited by 639 publications

References 175 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Preparation of tunable-sized iron nanoparticles based on magnetic manipulation in inert gas condensation (IGC)

Influence of carbon nanotubes support on the morphology of Fe3O4 nanoparticles

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