Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) are promising drug delivery carriers and hyperthermia agents for the treatment of cancer. However, to ensure their safety in vivo, SPIONs must be modified in order to prevent unwanted iron release. Thus, SPIONs were coated with silica layers of different morphologies: non-porous (@SiO2), mesoporous (@mSiO2) or with a combination of non-porous and mesoporous layers (@SiO2@mSiO2) deposited via a sol–gel method. The presence of SiO2 drastically changed the surface properties of the nanoparticles. The zeta potential changed from 19.6 ± 0.8 mV for SPIONs to −26.1 ± 0.1 mV for SPION@mSiO2. The Brunauer–Emmett–Teller (BET) surface area increased from 7.54 ± 0.02 m2/g for SPIONs to 101.3 ± 2.8 m2/g for SPION@mSiO2. All types of coatings significantly decreased iron release (at least 10 fold as compared to unmodified SPIONs). SPIONs and SPION@mSiO2 were tested in vitro in contact with human lung epithelial cells (A549 and BEAS-2B). Both nanoparticle types were cytocompatible, although some delay in proliferation was observed for BEAS-2B cells as compared to A549 cells, which was correlated with increased cell velocity and nanoparticles uptake.

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

“…Over the past several years, there has been a great development of iron oxide-based magnetic nanoparticles application in many scientific fields, including biomedical engineering [ 1 , 2 ], cell labeling [ 3 , 4 ], cancer treatment [ 5 , 6 , 7 ], magnetic drug delivery [ 8 , 9 ], multimodal imaging [ 10 , 11 ], and Magnetic Resonance Imaging (MRI) contrast agents [ 12 , 13 , 14 ], due to their unique and diverse biomedical properties. Depending on their composition and surface modification, they recently focused attention on the targeted anticancer treatment and mild magnetic hyperthermia (MH) [ 15 , 16 , 17 ].…”

Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

“…In general, to prevent the agglomeration of nanoparticles and to improve their colloidal stability and biological properties, they are incorporated into polymers (chitosan, dextran, poly(vinyl alcohol)—PVA, gelatin, polyvinylpyrrolidone (PVP), etc.) [ 6 , 13 , 14 , 15 , 16 ]. Dextran, (H(C 6 H 10 O 5 )xOH), is one of the most widely used natural polysaccharides used as a coating for SPION [ 1 ].…”

The Efficacy of 18F-FDG PET/CT and Superparamagnetic Nanoferric Oxide MRI in the Diagnosis of Lung Cancer and the Value of 18F-FDG PET/CT in the Prediction of Lymph Node Metastasis

“…The T2-weighted signal of normal lung tissue was reduced and appeared black, while the pathological lung tissue showed no reticuloendothelial cell phagocytosis and no T2-weighted signal change. In this way, the contrast between lung lesions and normal tissues is increased, resulting in improved diagnostic sensitivity and specificity and improved diagnostic efficiency [18][19][20]. Due to the uneven distribution of superparamagnetic iron oxide nanoparticles in patients, the relaxation rate of superparamagnetic iron oxide nanoparticles is higher and the blood circulation time is prolonged.…”