Superparamagnetic nanoparticles as versatile carriers and supporting materials for enzymes

Netto, Caterina Gruenwaldt Cunha Marques; Toma, Henrique E.; Andrade, Leandro H.

doi:10.1016/j.molcatb.2012.08.010

Cited by 294 publications

(93 citation statements)

References 226 publications

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“…The oxidase is of interest for detecting glycated proteins, a marker for hyperglycemia in diabetes patients (Qian et al 2013). Furthermore, D-amino acid oxidases are widely used for the quantification of Damino acids in biological samples by virtue of their strict stereospecificity (Netto et al 2013).…”

Section: Flavoprotein Oxidases In Biotechnologymentioning

confidence: 99%

Flavoprotein oxidases: classification and applications

Dijkman

Gonzalo

Mattevi

et al. 2013

Appl Microbiol Biotechnol

132

106

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This review provides an overview of oxidases that utilise a flavin cofactor for catalysis. This class of oxidative flavoenzymes has shown to harbour a large number of biotechnologically interesting enzymes. Applications range from their use as biocatalysts for the synthesis of pharmaceutical compounds to the integration in biosensors. Through the recent developments in genome sequencing, the number of newly discovered oxidases is steadily growing. Recent progress in the field of flavoprotein oxidase discovery and the obtained biochemical knowledge on these enzymes are reviewed. Except for a structure-based classification of known flavoprotein oxidases, also their potential in recent biotechnological applications is discussed.

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Section: Flavoprotein Oxidases In Biotechnologymentioning

confidence: 99%

Flavoprotein oxidases: classification and applications

Dijkman

Gonzalo

Mattevi

et al. 2013

Appl Microbiol Biotechnol

132

106

View full text Add to dashboard Cite

show abstract

“…A major application is in the biomedical area as a carrier for drug/gene delivery [300,327,343,485], biomarkers [205], and agrochemicals in plants [383], as nanoparticles can often cross physiological barriers and reach different tissues in a controllable style. Various particles have been reported, including polymeric [101], silica [365,410], magnetic [236,295,404], noble metal (especially Au nanoparticles) [12,90], quantum dots [347], lipid [7,29,230], micelles [189], dendrimers [313], hybrid structures [143,144], and even the new emerging nano-diamond [268]. The particle's size, shape, rigidity, surface charge, and ligand density all have an effect on particle-cellular uptake [419,467].…”

Section: à18mentioning

confidence: 99%

Application of Nanoparticles in Manufacturing

Hu¹,

Tuck²,

Wildman³

et al. 2015

Handbook of Nanoparticles

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With the development of nanoscience and nanotechnology, manufacturing is undergoing revolutionary changes. Nanoparticles, due to their novel and often enhanced properties, are now more and more used in manufacturing. In this chapter, the state-of-the-art application of nanoparticles in manufacturing is reviewed. The contents include five parts: (a) role of nanoparticles in manufacturing, (b) manufacturing methods, (c) applications, (d) challenges, and (e) conclusions. The roles of nanoparticles are divided into three categories: (i) building blocks, being the major component of a manufactured product by solid-state or colloidal nanoparticle consolidation; (ii) functional filler, as an addition for functionality, such as property improver, catalyst, stimuli-responsive, sensing, imaging, and carrier; and (iii) nanocomposites for multifunctionality. Various manufacturing methods and novel trends are summarized in this chapter, including top-down and bottom-up, from 2D to 3D, from cleanroom to desktop, 3D printing, and bio-assisted methods, such as DNA origami. Direct applications in areas of flexible electronics, molecular electronics, solar cells, construction industry, water treatment, and biomedical devices are presented. The associated challenges including nanoparticle safety issue, sustainable manufacturing, economic issue, and scale-up are discussed. Role of Nanoparticles in ManufacturingWith the development of nanoscience and nanotechnology, manufacturing is undergoing revolutionary changes. Nanoparticles, due to their novel and often enhanced properties, have more and more been used in various manufacturing applications. Their role can generally be divided into three categories: (a) building blocks, (b) functional filler, and (c) nanocomposites for multifunctionality, which is summarized in Table 1. Building BlockNanoparticles sometimes act like the bricks in a house-building process to be the main component of a manufactured product. They can be consolidated via solid-and liquid-based methods. Solid-State Nanoparticle ConsolidationSolid-state metallic, ceramic, amorphous, and compound particles can be thermomechanically processed to form bulk 2D/3D structures with desired strength and level of densification (even full densification is possible). Reported methods include powder compact forging/extrusion, equal channel angular extrusion/ pressing, and hot pressing/sinter forging combined with conventional heating, laser sintering, microwave sintering, electric discharge sintering, or spark plasma sintering [33,255,278,306,425,426,476,492]. Particles with a narrow size distribution and spherical shape are desired to achieve low pore-to-

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“…Supermagnets of Nd2Fe14B displaying strong magnetic fields are quite available in the market, and are suitable for this purpose. However, one has to carefully consider the biomolecule linking procedure to the nanoparticle beforehand, since the coupling method can impact the enzyme catalytic activity and its immobilization efficiency (Rebelo et al, 2010;Netto et al, 2009Netto et al, , 2011Netto et al, , 2012Netto et al, , 2013Netto et al, , 2015. A large variety of methods has already been employed (Netto et al, 2013); however, they have led to very contrasting results.…”

Section: Introductionmentioning

confidence: 99%

“…Among the inorganic supports used for the attachment of proteins, many interesting advantages could be achieved by using magnetite nanoparticles (Netto et al, 2013). Superparamagnetic materials allow a convenient separation of the catalyst from the reaction medium by simply using an external magnetic field.…”

Section: Introductionmentioning

confidence: 99%