Superresolution microscopy imaging based on full-wave modeling and image reconstruction

Chen, Rui; Wu, Minxian; Ling, Jinzhong; Wei, Zhun; Chen, Zaichun; Hong, Minghui; Chen, Xudong

doi:10.1364/optica.3.001339

Cited by 11 publications

(5 citation statements)

References 43 publications

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“…The generated Airy beam coming out of the FTL illuminates the sample. Similar to a general microscopy modality, [ 28 ] the metallic sample in the current setup is scanned in an xy plane at z = 100 mm with a step of 0.5 mm while the receiving antenna is kept stationary at (0, 0, 110 mm) in the close vicinity of the sample to detect the sub‐THz signals scattered by the sample. We record the parameter S 21 from 90 to 110 GHz at each scanning location of the receiving antenna by the VNA connecting the two antennas.…”

Section: Experiments and Resultsmentioning

confidence: 99%

Enhanced Sub‐Terahertz Microscopy based on Broadband Airy Beam

Zhang

Liu

Yao

et al. 2021

Adv Materials Technologies

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Non‐diffraction electromagnetic beams such as Airy beams attract wide exploration in various disciplines owing to its fascinating features and great potential of applications. Although generation and applications of Airy beams are actively studied in the optical regime, applications of Airy beams in the THz or sub‐THz domain are rarely explored. This work proposes a new microscopic technique leveraging a sub‐THz broadband non‐diffraction Airy beam as the illumination beam to improve the image quality, which is named as enhanced sub‐THz microscopy (ESTM). The effectiveness of the ESTM is validated by a metallic sample, which shows that applying broadband measured information can render a better image quality than only using single‐frequency information. By blocking the sample using a scattering obstacle, it is demonstrated that the self‐reconstruction property of the Airy beam can efficiently suppress the distortion induced by the obstacle and good images can still be obtained. In addition, it is shown that the image quality applying a broadband Airy beam is superior to that of non‐diffraction quasi‐Bessel beams and other conventionally used illumination beams for microscopic technique.

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Section: Experiments and Resultsmentioning

confidence: 99%

Enhanced Sub‐Terahertz Microscopy based on Broadband Airy Beam

Zhang

Liu

Yao

et al. 2021

Adv Materials Technologies

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“…The exploitation of a full‐wave forward model of image formation and the reconstruction of super‐resolved information by the solution of the inverse problem is shared by SR methods in a variety of imaging modalities, ranging from confocal fluorescence microscopy in the visible spectral range [ 36 ] to mid‐IR thermography. Such SR thermographic techniques have been targeted to the 3D identification and reconstruction of subsurface material defects in nondestructive testing on the millimeter spatial scale, [ 21 ] whereas model‐based reconstruction is specifically directed here to the enhancement of the radial spatial resolution.…”

Section: Discussionmentioning

confidence: 99%

Super‐Resolution Photothermal Imaging at the Microscale by Model‐Based Image Reconstruction

Presotto,

Marini,

Chirico

et al. 2023

Advanced Intelligent Systems

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Super‐resolution strategies expand the applicability of imaging modalities toward previously inaccessible spatial scales. Herein, photoactivated far‐infrared thermography is pushed from the millimeter to the micrometer scale by a 2D super‐resolution imaging approach capable of tackling the resolution barriers imposed by both diffraction‐limited signal collection and lateral spatiotemporal heat diffusion. The proposed imaging strategy relies on a full‐wave forward model of far‐infrared thermography and on an image‐inversion approach, which reconstructs the surface distribution of the sample photothermal absorbers via gradient‐descent optimization as the one yielding the best match between predicted and experimental images. With minute‐long acquisitions on a commercial low‐cost far‐infrared camera, less‐than‐5 μm spatial resolution is demonstrated on both synthetic samples and human liver biopsies ex vivo, thereby exemplifying the applicability of super‐resolution photothermal imaging to the fast nondestructive characterization of biological specimens well below the tissue spatial scale.

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“…Membrane-based holders provide a more robust solution to control the microsphere. In the pioneering studies, microspheres were fixed on a transparent glass strip by van der Waals forces (Chen et al, 2016). The process to prepare such a holder is simple and straightforward.…”

Section: Membrane-based Non-contact Methodsmentioning

confidence: 99%

“…Hence, a mechanical system with high-accuracy control was proposed to fulfill these requirements (Chen et al, 2016(Chen et al, , 2018a. The holder was made of steel, and the schematic of such a setup is presented in Figure 2C.…”

Section: Membrane-based Non-contact Methodsmentioning

confidence: 99%

“…Besides the tapered glass rod, other objects can also be considered to make a tip-based holder, including atomic force microscope (AFM) tip, needle, or even human hair (Chen et al, 2016;Duocastella et al, 2017;Wang et al, 2015). AFM system provides some privileges as a sample holder, as AFM platform has the entire system with the mechanical control at high accuracy.…”

Section: Ll Open Accessmentioning

confidence: 99%

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Microsphere—Toward Future of Optical Microscopes

Chen

Zhou

et al. 2020

iScience

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choice. At present, the bottleneck challenge for the optical microscopes is its capability of imaging resolution. This fundamental limitation has existed for so long, and many people had even believed that it was impossible to breakthrough such physical law. Researchers have been seeking alternative solutions to bypass it. Microsphere Creating a New RouteMicrospheres provide the opportunity to directly face and overcome this challenge (Chen et al., 2019b). The discovery of microspheres' special light manipulation properties dated back to the year 2000 . In the experiment of laser cleaning, scientists were trying to remove the micro/nano-particles on a flat silicon wafer surface (

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Superresolution microscopy imaging based on full-wave modeling and image reconstruction

Cited by 11 publications

References 43 publications

Enhanced Sub‐Terahertz Microscopy based on Broadband Airy Beam

Enhanced Sub‐Terahertz Microscopy based on Broadband Airy Beam

Super‐Resolution Photothermal Imaging at the Microscale by Model‐Based Image Reconstruction

Microsphere—Toward Future of Optical Microscopes

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