Superselective intra-arterial infusion chemotherapy for stage III/IV squamous cell carcinomas of the oral cavity: Midterm results

Ikushima, Ichiro; Korogi, Yukunori; Ishii, A.; Hirai, Toshinori; Yamura, Masayuki; Nishimura, Ryuichi; Baba, Yuji; Yamashita, Yasuyuki; Shinohara, Masanori

doi:10.1016/j.ejrad.2007.05.019

Cited by 13 publications

(5 citation statements)

References 10 publications

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“…In addition, histopathological degenerative changes were observed in 3 of 7 metastatic SNs in our study. Based on histopathological grading system by the previous report, these histopathological changes were evaluated as Grade I which indicates initial anti-tumor effect and remaining tumor structures [9,18]. It is also possible that intra-arterial cisplatin chemotherapy targeting the primary tumor has a therapeutic effect on subclinical metastatic SNs.…”

Section: Discussionmentioning

confidence: 99%

Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer

Sakashita¹,

Homma²,

Suzuki³

et al. 2012

Acta Oto-Laryngologica

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Conclusion.We concluded that intra-arterially injected cisplatin passed via lymph flow into sentinel nodes (SNs) as the platinum concentration in the SNs was higher than that in the non-sentinel nodes (NSNs). It is possible that pre-operative intra-arterial chemotherapy targeting primary cancer also has a therapeutic effect on subclinical metastatic SNs.Objectives. Intra-arterial chemoradiotherapy has been reported to be effective against not only primary tumors but also nodal metastases. We considered the hypothesis that intra-arterially injected cisplatin passed via lymph flow into regional nodes. This study aimed to investigate intra-arterially injected cisplatin distribution to regional nodes by comparing platinum concentrations in SNs and NSNs.Method. Five patients with T1-2 N0 tongue cancer were treated with preoperative intra-arterial chemotherapy (cisplatin, 100mg/m 2 ) targeting primary cancer. Partial glossectomy together with SN biopsy and elective neck dissection were performed two weeks after intra-arterial chemotherapy. Platinum concentrations in the lymph nodes were measured using a Zeeman atomic absorption spectrometer.Results. Thirteen SNs were harvested together with 8 NSNs from the adjacent areas to the SNs. Platinum concentrations were then measured, revealing a significant difference in platinum concentration between the SNs and the NSNs (mean±SD, 0.682±0.246 µg/g vs 0.506±0.274 µg/g; p=0.049).

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Section: Discussionmentioning

confidence: 99%

Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer

Sakashita¹,

Homma²,

Suzuki³

et al. 2012

Acta Oto-Laryngologica

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“…21 On the other hand, some authors have reported that low-dose arterial cisplatin (25-50 mg/body) is effective for head and neck cancers. 22,23 Elevating the dose concentration of anticancer drugs using arterial infusion may therefore lead to an improved local control. However, the advantages and safety of arterial chemotherapy and the optimal dose of anticancer drugs remain controversial.…”

Section: Efficacymentioning

confidence: 99%

Arterial chemoradiotherapy for carcinomas of the external auditory canal and middle ear

et al. 2014

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“…Intra-arterial infusion chemotherapy (IAIC) has the advan-tage of delivering a high concentration of drugs into a tumor [1]. While there have been a number of reports on superselective IAIC via the femoral artery using the Seldinger technique [2][3][4][5][6], the effectiveness of IAIC in the treatment of locally advanced head and neck cancer remains controversial [7]. IAIC for tongue cancer can provide good local control and functional preservation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Origin of Feeding Arteries in Recurrent Tongue Cancers Treated with Intra-Arterial Infusion Chemotherapy

Kamitani

Yamasaki

Asayama

et al. 2018

Interventional Radiology

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Purpose: To evaluate the origin of feeding arteries in recurrent tongue cancers under treatment with intraarterial infusion chemotherapy (IAIC).Material and Methods: Eleven patients who underwent IAIC for recurrent tongue cancer at our institute between January 2007 and August 2017 were enrolled. Two patients received a second IAIC treatment for tumor recurrence after the first round of IAIC. Thus, 13 recurrent tongue tumors were evaluated. The main and accompanying feeding arteries were identified on super-selective angiography of the branches of the external carotid artery.Results: The main feeding artery was the ipsilateral lingual artery (LA) in 7 of the 13 (54%) tumors, the contralateral LA in 3 (24%) tumors, and the ipsilateral superior thyroid artery (STA) in 3 (24%) tumors. Feeding was detected from the ipsilateral LA in 12 of the 13 tumors (92%), from the contralateral LA in 8 (62%), from the ipsilateral facial artery (FA) in 3 (23%), from the contralateral FA in 1 (8%), from the ipsilateral STA in 3 (23%), from the contralateral STA in 2 (15%), and from the artery anastomosed to a flap in 2 (15%). Three tumors (23%) had only 1 feeding artery, and multiple feeders were detected in the remaining 10 (77%). Of the 10 tumors with multiple feeding arteries, 4 tumors had 2 feeding arteries, 4 tumors had 3 feeding arteries, and the other 2 tumors had 4 feeding arteries.Conclusions: Recurrent tongue cancers are often supplied by multiple feeding arteries. A careful search for feeding arteries including the STA is required.

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Superselective intra-arterial infusion chemotherapy for stage III/IV squamous cell carcinomas of the oral cavity: Midterm results

Cited by 13 publications

References 10 publications

Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer

Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer

Arterial chemoradiotherapy for carcinomas of the external auditory canal and middle ear

Evaluation of the Origin of Feeding Arteries in Recurrent Tongue Cancers Treated with Intra-Arterial Infusion Chemotherapy

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