1999
DOI: 10.1097/00004850-199903000-00009
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Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia

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Cited by 31 publications
(16 citation statements)
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“…Antipsychotic-naïve patients with first-episode schizophrenia form disorders and schizophrenia show both increased [20] and decreased [21] SOD activity in red blood cells. Human blood platelets have frequently been used as a peripheral model in the field of biological psychiatry [8][9][10]. Based on monoamine receptor hypothesis for mood disorders, the signaling pathway mediated by platelet 2 -adrenergic receptors has been intensively investigated as one of the most promising biological markers of depression [22,23].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Antipsychotic-naïve patients with first-episode schizophrenia form disorders and schizophrenia show both increased [20] and decreased [21] SOD activity in red blood cells. Human blood platelets have frequently been used as a peripheral model in the field of biological psychiatry [8][9][10]. Based on monoamine receptor hypothesis for mood disorders, the signaling pathway mediated by platelet 2 -adrenergic receptors has been intensively investigated as one of the most promising biological markers of depression [22,23].…”
Section: Discussionmentioning
confidence: 99%
“…In the present study we analyzed the relation between a common marker of oxidative stress (TBARS) and the activity of SOD in blood platelets of selected schizophrenia patients. Blood platelets are considered to be a peripheral marker in psychiatric illnesses [8][9][10] and they are a very good model for the study of oxidative stress. Human platelets share several characteristics with central nervous system neurons.…”
Section: Introductionmentioning
confidence: 99%
“…In a metaanalysis [86] of 10 studies, higher levels (standardized mean difference = 0.64; 95%CI = 0.21-1.06) of glutamate have been reported in blood from people with Sz compared to controls, however, similar dysregulations have been reported in the small number of studies that focused on major depressive disorder [90,91] , suggesting the alteration of glutamate levels is not specific to the diagnosis of Sz. Interestingly, the response of platelet intracellular calcium to glutamate was greater in people with Sz than in controls, suggesting NMDA receptor may be more sensitive in these people [87] . A single study has reported that people with Sz had higher levels of plasma agmatine, an endogenous substance that is synthesized from Larginine and is proposed to be a new neurotransmitter, than controls [88] , and that the levels correlated with their PANSS score, suggesting that plasma agmatine levels may be a potential diagnostic biomarker for Sz.…”
Section: Glutamatergic Pathwaysmentioning
confidence: 95%
“…Human platelets share several characteristics with central nervous system neurons (Murphy and Donnelly 1974;Magos 1998Magos , 2001. Moreover, some studies show the association between cardiovascular and mental diseases, including depression and schizophrenia (Allebeck 1989;Berk et al 1999;Plein and Berk 2001;Bakken et al 2006). Standardized mortality ratios (SMR) due to cardiovascular disease in schizophrenic patients are several times higher than in general population (SMR 08.3 for men; SMR 05.0 for women) (Allebeck and Wistedt 1986).…”
Section: Introductionmentioning
confidence: 99%