2010
DOI: 10.3109/15622970903144020
|View full text |Cite
|
Sign up to set email alerts
|

The effects of the second generation antipsychotics and a typical neuroleptic on collagen-induced platelet aggregationin vitro

Abstract: The obtained results indicate that the difference in action of tested drugs on platelet aggregation may dependent on the various chemical structures of these drugs. Clozapine, risperidone and haloperidol are structurally diverse, and they all significantly reduce platelet aggregability induced by collagen. On the other hand, a close structural analog of clozapine - olanzapine - did not inhibit platelet aggregation. However, mechanism of antipsychotics action on blood platelets is not clear. Moreover, it seems … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2010
2010
2023
2023

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 14 publications
(3 citation statements)
references
References 36 publications
0
3
0
Order By: Relevance
“…The occlusion/occlusion-like syndrome conceptual background as a large multicausal class effect, peripheral and central was realized only quite recently [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Here, there was a general cytoprotective endothelial threat (i.e., a disturbed dopamine system as a long-lasting essential pitfall in cytoprotection maintenance [ 30 , 31 , 32 , 33 , 34 , 35 ], endothelium lesions, and thrombosis induced by neuroleptics [ 36 , 37 , 38 , 39 , 40 , 41 ], domperidone [ 42 ], and amphetamine [ 43 , 44 , 45 ]). This accorded a major challenge of multicausal pathology (i.e., major vessel occlusion [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ] peripherally and centrally and similar noxious procedures [ 19 , 20 , 21 , 22 , 23 , 24 ] severely affecting endothelium function).…”
Section: Introductionmentioning
confidence: 99%
“…The occlusion/occlusion-like syndrome conceptual background as a large multicausal class effect, peripheral and central was realized only quite recently [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Here, there was a general cytoprotective endothelial threat (i.e., a disturbed dopamine system as a long-lasting essential pitfall in cytoprotection maintenance [ 30 , 31 , 32 , 33 , 34 , 35 ], endothelium lesions, and thrombosis induced by neuroleptics [ 36 , 37 , 38 , 39 , 40 , 41 ], domperidone [ 42 ], and amphetamine [ 43 , 44 , 45 ]). This accorded a major challenge of multicausal pathology (i.e., major vessel occlusion [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ] peripherally and centrally and similar noxious procedures [ 19 , 20 , 21 , 22 , 23 , 24 ] severely affecting endothelium function).…”
Section: Introductionmentioning
confidence: 99%
“…We test the effect of antipsychotics on ADP and collagen as widely used platelet agonists, that has been previously tested with antipsychotics with controversial results [10][11][12][13]. No significant effect of any antipsychotics (at high concentration) used on platelet aggregation induced by ADP or collagen was observed, this result was expected as no affinity of antipsychotics for ADP purinergic receptors or collagen platelet receptors was shown previously.…”
Section: Link Between Platelets 5-ht Cardiovascular Disorders and Amentioning
confidence: 81%
“…Several antipsychotic drugs that antagonize 5-HT 2A receptor such as clozapine, risperidone and olanzapine have demonstrated some inhibitory effects on platelet aggregation induced by platelet agonists such as collagen, adenosine diphosphate (ADP) and 5-HT in in vitro studies [10][11][12]. However, in one study clozapine markedly increased platelet aggregation induced by 5-HT [13].…”
Section: (Page Number Not For Citation Purposes)mentioning
confidence: 99%