Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels

Shaalan, Aly A. M.; El-Sherbiny, Mohamed; El-Abaseri, Taghrid B.; Shoaeir, Mohamed Z.; Abdel-Aziz, Tarek M.; Mohamed, Magda I.; Zaitone, Sawsan A.; Mohammad, Hala M.F.

doi:10.3389/fphar.2020.00583

Cited by 8 publications

(3 citation statements)

References 43 publications

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“…OPN plays an important role in tissue remodeling, immunomodulation, and biomineralization by binding to diverse receptors, such as integrins and CD44 (165)(166)(167). In bone tissue, OPN can anchor osteoclasts to the bone mineral matrix to promote bone resorption (167)(168)(169); therefore, patients with high serum OPN concentrations have low bone mineral densities, whereas patients with low serum OPN concentrations have high bone mineral densities (170). In the brain, OPN forms different fragments after protease cleavage.…”

Section: Opnmentioning

confidence: 99%

Aerobic Physical Exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond

et al. 2022

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Brain disorders, including stroke, Alzheimer's disease, depression, and chronic pain, are difficult to effectively treat. These major brain disorders have high incidence and mortality rates in the general population, and seriously affect not only the patient's quality of life, but also increases the burden of social medical care. Aerobic physical exercise is considered an effective adjuvant therapy for preventing and treating major brain disorders. Although the underlying regulatory mechanisms are still unknown, systemic processes may be involved. Here, this review aimed to reveal that aerobic physical exercise improved depression and several brain functions, including cognitive functions, and provided chronic pain relief. We concluded that aerobic physical exercise helps to maintain the regulatory mechanisms of brain homeostasis through anti-inflammatory mechanisms and enhanced synaptic plasticity and inhibition of hippocampal atrophy and neuronal apoptosis. In addition, we also discussed the cross-system mechanisms of aerobic exercise in regulating imbalances in brain function, such as the “bone-brain axis.” Furthermore, our findings provide a scientific basis for the clinical application of aerobic physical exercise in the fight against brain disorders.

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Section: Opnmentioning

confidence: 99%

Aerobic Physical Exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond

et al. 2022

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“…Calcium is a vital nutrient for human health, accounting for about 1.5–2% of human body weight [ 1 ]. Calcium deficiency may provoke a series of diseases, such as osteopenia, osteoporosis, high blood pressure, and kidney stones [ 2 ]. Currently, there are a variety of commercial calcium supplements, including inorganic calcium, organic calcium [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Structural Characterization, and Stability of Low-Molecular-Weight Collagen Peptides–Calcium Chelate Derived from Tuna Bones

Zhong,

Zhou,

et al. 2023

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This study was conducted to prepare calcium chelate of low-molecular-weight tuna bone collagen peptides (TBCPLMW) with a high chelation rate and to identify its structural characteristics and stability. The optimum conditions for calcium chelation of TBCPLMW (TBCPLMW-Ca) were determined through single-factor experiments and response surface methodology, and the calcium-chelating capacity reached over 90% under the optimal conditions. The amino acid compositions implied that Asp and Glu played important roles in the formation of TBCPLMW-Ca. Structural characterizations determined via spectroscopic analyses revealed that functional groups such as -COO−, N-H, C=O, and C-O were involved in forming TBCPLMW-Ca. The particle size distributions and scanning electron microscopy results revealed that folding and aggregation of peptides were found in the chelate. Stability studies showed that TBCPLMW-Ca was relatively stable under thermal processing and more pronounced changes have been observed in simulated gastric digestion, presumably the acidic environment was the main factor causing the dissociation of the TBCPLMW-Ca. The results of this study provide a scientific basis for the preparation of a novel calcium supplement and is beneficial for comprehensive utilization of tuna bones.

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“…The enzymes of glucose metabolism, including glucose transporter 1 (GLUT1), are regulated by HIF-1, and the expression of these genes regulated by HIF1 alters intracellular biological functions such as glucose uptake and energy production [ 7 , 8 ], which is associated with cancer cell proliferation and poor prognosis in tumours [ 9 , 10 ]. Studies have shown that ginsenoside can inhibit the growth of liver or lung cancers by inhibiting hypoxia-inducible factor-1α (HIF-1α)-mediated glucose metabolism [ 11 , 12 ]. With the deepening of research, it has been found that secondary ginsenosides and aglycones produced by the degradation of ginsenosides have stronger pharmacological effects [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1α-GLUT1 pathway

et al. 2021

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Background Ginsenosides have been reported to possess a variety of biological activities. Synthesized from the ginsenoside protopanaxadiol (PPD), the octanone pseudoginsengenin DQ (PDQ) may have robust pharmacological effects as a secondary ginsenoside. Nevertheless, its antitumour activity and molecular mechanism against hypopharyngeal cancer cells remain unclear. Methods Cell Counting Kit8 assays, cell cycle assays and cell apoptosis assays were conducted to assess FaDu cell proliferation, cell phase and apoptosis. The interactions between PDQ and HIF-1α were investigated by a molecular docking study. The expression of HIF-1α, GLUT1, and apoptosis-related proteins was detected by Western blotting, direct stochastic optical reconstruction microscopy (dSTORM) and qRT-PCR. A glucose uptake assay was used to assess the glucose uptake capacity of FaDu cells. Results PDQ suppressed proliferation, reduced glucose uptake, and induced cell cycle arrest and apoptosis in FaDu cells. A molecular docking study demonstrated that PDQ could interact with the active site of HIF-1α. PDQ decreased the expression and mRNA levels of HIF-1α and its downstream factor GLUT1. Moreover, the dSTORM results showed that PDQ reduced GLUT1 expression on the cell membrane and inhibited GLUT1 clustering. Conclusion Our work showed that the antitumour effect of PDQ was related to the downregulation of the HIF-1α-GLUT1 pathway, suggesting that PDQ could be a potential therapeutic agent for hypopharyngeal cancer treatment.

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Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels

Cited by 8 publications

References 43 publications

Aerobic Physical Exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond

Aerobic Physical Exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond

Preparation, Structural Characterization, and Stability of Low-Molecular-Weight Collagen Peptides–Calcium Chelate Derived from Tuna Bones

Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1α-GLUT1 pathway

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