Supplemental Oxygen During High-Intensity Exercise Training in Nonhypoxemic Chronic Obstructive Pulmonary Disease

Neunhäuserer, Daniel; Steidle-Kloc, Eva; Weiss, Gertraud; Kaiser, Bernhard; Niederseer, David; Hartl, Sylvia; Tschentscher, Marcus; Egger, Andrea; Schönfelder, Martin; Lamprecht, Bernd; Studnicka, Michael; Niebauer, Josef

doi:10.1016/j.amjmed.2016.06.023

Cited by 40 publications

(65 citation statements)

References 32 publications

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“…Interestingly, the patient dropout rates were low to moderate throughout all included studies (i.e., 21.9% with supplemental oxygen and 21.8% in normoxia). Moreover, even in those studies with the highest dropout rates [70][71][72][73], no associations between the FiO 2 (0.35 to 1.0) or flow rate (2 to 10 L min −1 ) and the number of dropouts were observed. In addition, the reported training adherence ranged from 89 to 100% for both conditions.…”

Section: Discussionmentioning

confidence: 79%

Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?

Freitag

Doma

Neunhäeuserer

et al. 2020

JPM

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Aim: This systematic review aimed to explore the literature to identify in which types of chronic diseases exercise with supplemental oxygen has previously been utilized and whether this type of personalized therapy leads to superior effects in physical fitness and well-being. Methods: Databases (PubMed/MEDLINE, CINHAL, EMBASE, Web of knowledge and Cochrane Library) were searched in accordance with PRISMA. Eligibility criteria included adult patients diagnosed with any type of chronic diseases engaging in supervised exercise training with supplemental oxygen compared to normoxia. A random-effects model was used to pool effect sizes by standardized mean differences (SMD). Results: Out of the identified 4038 studies, 12 articles were eligible. Eleven studies were conducted in chronic obstructive pulmonary disease (COPD), while one study included coronary artery disease (CAD) patients. No statistical differences were observed for markers of physical fitness and patient-reported outcomes on well-being between the two training conditions (SMD −0.10; 95% CI −0.27, 0.08; p = 0.26). Conclusions: We found that chronic exercise with supplemental oxygen has mainly been utilized for COPD patients. Moreover, no superior long-term adaptations on physical fitness, functional capacity or patient-reported well-being were found, questioning the role of this method as a personalized medicine approach. Prospero registration: CRD42018104649.

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Section: Discussionmentioning

confidence: 79%

Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?

Freitag

Doma

Neunhäeuserer

et al. 2020

JPM

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“…Short-term effects of oxygen supplementation on exercise performance appear more conclusive. Indeed, oxygen supplementation (10 L/min) in 29 patients with non-hypoxaemic COPD during exercise doubled peak work rates compared with room air 35. This, however, is not a typical real-life approach.…”

Section: Exercise Training Combined With Oxygen Supplementation or Nomentioning

confidence: 99%

Pulmonary rehabilitation, physical activity, respiratory failure and palliative respiratory care

Spruit

Rochester

Pitta

et al. 2019

Thorax

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“…In den Studien mit COPD-Patienten fanden sich 44 verschiedene Ausschlusskriterien (Abb 2). Von diesen waren belastungseinschränkende Erkrankungen [34, 36, 40, 53, 60, 61, 89, 92, 104, 114, 125, 134, 135, 138, 148, 157, 166-170, 173, 174, 179, 181, 183, 184] (n = 27; 17,3%) das am häufigsten berichtete Ausschlusskriterium, gefolgt von allgemeiner kardiovaskulärer Erkrankung [32, 39, 44, 70, 74, 75, 94, 100, 103, 107, 109, 112, 130, 152, 153, 160, 164, 171] (n = 18; 11,5%) und instabiler kardiovaskulärer Erkrankung 38, 47, 53, 65, 66, 98, 99, 101, 108, 116–119, 133, 137, 146, 147, 180] (n = 18; 11,5%). Vierunddreißig Studien (21,8%) [23, 48, 50, 55, 63, 67, 69, 73, 77-80, 83, 84, 86, 88, 91, 95, 97, 110, 111, 115, 122, 126, 127, 132, 142, 149, 150, 155, 161, 165, 175, 185] enthielten keine Angaben zu den Eignungskriterien für kardiovaskuläre Komorbiditäten.…”

Section: Ergebnisseunclassified

Bewegungstraining bei Patienten mit chronischen Atemwegserkrankungen: Werden kardiovaskuläre Komorbiditäten und Outcomes berücksichtigt? Eine systematische Übersichtsarbeit

et al. 2020

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Patienten mit chronisch-obstruktiver Lungenerkrankung (COPD), Asthma und interstitiellen Lungenerkrankungen (ILD) weisen häufig kardiovaskuläre Komorbiditäten (KVK) auf. Bewegungstraining ist eine tragende Säule bei der Behandlung dieser Erkrankungen, doch existieren kaum Empfehlungen zur maßgeschneiderten Anpassung von Programmen für Patienten mit Atemwegserkrankungen und KVK. Ziel der vorliegenden systematischen Übersichtsarbeit war es, die Eignungskriterien zu identifizieren, die für die Auswahl von Patienten mit COPD, Asthma oder ILD und KVK für Bewegungsprogramme herangezogen werden, und die Auswirkungen von Bewegung auf die kardiovaskulären Outcomes zu bewerten. Darüber hinaus sollte festgestellt werden, wie Bewegungsprogramme auf Patienten mit KVK zugeschnitten wurden. Es erfolgte eine Suche in den Datenbanken PubMed, Scopus, Web of Science und Cochrane. Drei Reviewer extrahierten die Daten, und zwei Reviewer bewerteten unabhängig voneinander die Qualität

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Supplemental Oxygen During High-Intensity Exercise Training in Nonhypoxemic Chronic Obstructive Pulmonary Disease

Cited by 40 publications

References 32 publications

Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?

Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?

Pulmonary rehabilitation, physical activity, respiratory failure and palliative respiratory care

Bewegungstraining bei Patienten mit chronischen Atemwegserkrankungen: Werden kardiovaskuläre Komorbiditäten und Outcomes berücksichtigt? Eine systematische Übersichtsarbeit

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