2021
DOI: 10.1016/j.jacc.2020.09.619
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Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment

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Cited by 69 publications
(33 citation statements)
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“…So far, vitamin D supplementation has been viewed as the only treatment option in individuals with vitamin deficiency, and a range of 30–35 ng/ml was proposed to obtain a satisfactory CV prevention ( 153 ). However, with the exception of the beneficial effects of supplement of the active form of vitamin D in patients with ESRD, all RCT have failed to demonstrate favorable effects of vitamin supplement on CV outcome ( 154 , 155 ). On the contrary, there are clear evidence that correction of IR status by both pharmacological and non-pharmacological interventions favorably affects CV risk and prognosis ( 156 – 158 ).…”
Section: Improvement Of the Vitamin D-based Strategies In CV Preventionmentioning
confidence: 99%
“…So far, vitamin D supplementation has been viewed as the only treatment option in individuals with vitamin deficiency, and a range of 30–35 ng/ml was proposed to obtain a satisfactory CV prevention ( 153 ). However, with the exception of the beneficial effects of supplement of the active form of vitamin D in patients with ESRD, all RCT have failed to demonstrate favorable effects of vitamin supplement on CV outcome ( 154 , 155 ). On the contrary, there are clear evidence that correction of IR status by both pharmacological and non-pharmacological interventions favorably affects CV risk and prognosis ( 156 – 158 ).…”
Section: Improvement Of the Vitamin D-based Strategies In CV Preventionmentioning
confidence: 99%
“…The history of this complex issue was reviewed in 2019 [24]. Two more recent meta-analyses have confirmed that folic acid and B vitamin combinations reduce the risk of stroke [25,26]. Metabolic B12 deficiency with hyperhomocysteinemia is very common and easily treated [27]; the ongoing neglect of this opportunity to reduce the risk of stroke should not be permitted to persist.…”
Section: Dietmentioning
confidence: 99%
“…Based on this finding, measurement of serum folate levels should be considered in patients with RVO, and patients should be advised to control folate levels, so as to reduce the risk of another vascular event in the fellow eye. Supplementation of dietary intake with folate could be considered, but it should be taken into account that it may increase the risk for vascular closure, which was explained by "feeding" and growth of atherosclerotic cells [39]. Moreover, it should be noted that since serum folate measurement may present variation due to dietary habits, homocysteine measurement may be a more reliable biomarker in patients with RVO, taking into account its interaction with folate.…”
Section: Klinische Studiementioning
confidence: 99%