Supplementation of docosahexaenoic acid (DHA) / Eicosapentaenoic acid (EPA) in a ratio of 1/1.3 during the last trimester of pregnancy results in EPA accumulation in cord blood

Büyükuslu, Nihal; Ovali, Sema; Altuntaş, Şükriye Leyla; Batirel, Saime; Yiğit, Pakize; Garipağaoğlu, Muazzez

doi:10.1016/j.plefa.2017.08.005

Cited by 6 publications

(6 citation statements)

References 46 publications

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“…The World Health Organization (WHO) and the Food and Agriculture Organization of the United Nations (FAO) recommend a minimum consumption of 300 mg/day EPA-20:5 n -3 + DHA-22:6 n-3 for pregnant and lactating mothers, at least 200 mg/day of which should correspond to DHA-22:6 n-3 ( FAO and FINUT, 2008 ; B ü y ü kuslu et al, 2017 ). The sources of ALA-18:3 n-3 (metabolic precursor of EPA-20:5 n-3 and DHA-22:6 n-3 ) are mainly of plant origin and include nuts, flax, chia and hemp and soybean oils ( Vannice and Rasmussen, 2014 ), while EPA-20:5 n-3 and DHA-22:6 n-3 are found in shellfish and fish such as tuna, mackerel, salmon, sardine, horse mackerel, herring and smelt ( FAO and FINUT, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Pilot study of the effect of EPA + DHA supplementation on the fatty acid profile of erythrocytes and breast milk of lactating women from Sonsón, Colombia

Valencia-Naranjo

Manjarres-Correa

Bermúdez-Cardona

2022

Current Research in Food Science

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Section: Introductionmentioning

confidence: 99%

Pilot study of the effect of EPA + DHA supplementation on the fatty acid profile of erythrocytes and breast milk of lactating women from Sonsón, Colombia

Valencia-Naranjo

Manjarres-Correa

Bermúdez-Cardona

2022

Current Research in Food Science

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“…As discussed throughout this review, n‐6 FAs are largely believed to induce negative outcomes, although some studies have suggested limited benefits in CVD, which likely relate to their replacement of saturated FA. In the field of Developmental Origins of Health and Disease (DoHAD), much of the interest in maternal PUFA intake and fetal growth has focused on the potential beneficial effects of n‐3 FA, particularly in DHA for ameliorating disease associated with other maternal insults . Postnatal dietary n‐3 FA prevents programmed hyperleptinaemia, adiposity and hypertension in rats, suggesting that dietary supplementation with n‐3 FA may provide a therapeutic intervention for adverse programming outcomes in humans.…”

Section: Dietary Intervention For Adult Onset Of Disease Using Pufamentioning

confidence: 99%

“…In the field of Developmental Origins of Health and Disease (DoHAD), much of the interest in maternal PUFA intake and fetal growth has focused on the potential beneficial effects of n-3 FA, particularly in DHA for ameliorating disease associated with other maternal insults. 102,103 Postnatal dietary n-3…”

Section: Ie Tary Interventi On For Adult On S E T Of D Is E a S Ementioning

confidence: 99%

Role of omega‐6 and omega‐3 fatty acids in fetal programming

Shrestha

Sleep

Cuffe

et al. 2020

Clin Exp Pharma Physio

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Maternal nutrition plays a critical role in fetal development and can influence adult onset of disease. Linoleic acid (LA) and alpha‐linolenic acid (ALA) are major omega‐6 (n‐6) and n‐3 polyunsaturated fatty acids (PUFA), respectively, that are essential in our diet. LA and ALA are critical for the development of the fetal neurological and immune systems. However, in recent years, the consumption of n‐6 PUFA has increased gradually worldwide, and elevated n‐6 PUFA consumption may be harmful to human health. Consumption of diets with high levels of n‐6 PUFA before or during pregnancy may have detrimental effects on fetal development and may influence overall health of offspring in adulthood. This review discusses the role of n‐6 PUFA in fetal programming, the importance of a balance between n‐6 and n‐3 PUFAs in the maternal diet, and the need of further animal models and human studies that critically evaluate both n‐6 and n‐3 PUFA contents in diets.

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“…There is increasing number of studies on the amount of PUFA in the umbilical cord blood because of the fact that the FA content in the umbilical blood is an indicator of the FA that the fetus received in the prenatal period and a proxy to their concentration in fetal tissues (Buyukuslu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Stability of Fatty Acids in Erythrocytes from Human Umbilical Cord

Jaramillo

Garmendia

Muñóz

et al. 2020

Lipids

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The interest in the amount of polyunsaturated fatty acids (PUFA) in the umbilical cord blood (UCB) is increasing, but the stability of erythrocyte PUFA in these samples during storage and washing of the erythrocytes has not been directly evaluated. The purpose of this study was to analyze the effect of the lapse of time on the fatty acid (FA) content from UCB sample collection and maintained at 4 C (0-12 h) until erythrocyte separation and washing. Palmitic acid (16:0), stearic acid (18:0), 18:1n-7/n-9, linoleic acid (18:2n-6), arachidonic acid (20:4n-6), 22:4n-6, eicosapentaenoic acid (20:5n-3), docosapentaenoic acid (22:5n-3), and docosahexaenoic acid (22:6n-3) together accounted for 87% of the FA profile in the umbilical vein erythrocytes. No difference was observed in the concentration of any of the FA studied, nor in the sum of saturated fatty acids (SFA), PUFA, or LC-PUFA in umbilical erythrocytes obtained at delivery and stored up to 12 h before the separation of erythrocytes. However, if a washing step was included in the processing of the erythrocytes, a decrease in the concentration of 16:0, 18:0, 18:3n-3, 20:4n-6, 22:4n-6, total SFA, PUFA, LC-PUFA, and n-6 LC-PUFA was evidenced, compared to unwashed erythrocytes. The FA concentration in umbilical cord erythrocytes did not change between samples stored from 0 to 12 h until erythrocyte separation. Erythrocyte washing before storage decreased the concentration of significant individual and total SFA, PUFA, and LC-PUFA. These results should be considered when planning the collection of UCB samples for the study of fatty acid concentration due to the nonscheduled timing of deliveries.

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Supplementation of docosahexaenoic acid (DHA) / Eicosapentaenoic acid (EPA) in a ratio of 1/1.3 during the last trimester of pregnancy results in EPA accumulation in cord blood

Cited by 6 publications

References 46 publications

Pilot study of the effect of EPA + DHA supplementation on the fatty acid profile of erythrocytes and breast milk of lactating women from Sonsón, Colombia

Pilot study of the effect of EPA + DHA supplementation on the fatty acid profile of erythrocytes and breast milk of lactating women from Sonsón, Colombia

Role of omega‐6 and omega‐3 fatty acids in fetal programming

Evaluation of the Stability of Fatty Acids in Erythrocytes from Human Umbilical Cord

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