Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats

Veras, Allice Santos Cruz; Gomes, Rayana Loch; Tavares, Maria Eduarda Almeida; Giometti, Inês Cristina; Cardoso, Ana Paula Mattoso Miskulin; Alves, Beatriz da Costa Aguiar; Lenquiste, Sabrina Alves; Vanderlei, Luiz Carlos Marques; Teixeira, Giovana Rampazzo

doi:10.1038/s41598-021-85337-9

Cited by 20 publications

(13 citation statements)

References 40 publications

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“…In Apo E knockout mice, the fish oil-rich diet increased NO production and endothelial NO synthase (NOS) expression and lowered the expression of p22 phlox and O2-generation (16). Moreover, ω-3 PUFAs may increase antioxidant activity, such as superoxide dismutase (SOD), guaiacol peroxidase (GPX), catalase (CAT), and glutathione (GSH), enhancing the resistance to free radical attack and reducing lipid peroxidation and oxidative stress (17)(18)(19). Diet with a 1:1 ratio of EPA/DHA improved the oxidative stress parameters (SOD and GPX in erythrocytes) and plasma antioxidant capacity (19).…”

Section: Anti-oxidation and Improved Endothelial Functionmentioning

confidence: 99%

The Effects of Fish Oil on Cardiovascular Diseases: Systematical Evaluation and Recent Advance

Liao

Xiong

Yin

et al. 2022

Front. Cardiovasc. Med.

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Fish oil is rich in unsaturated fatty acids, i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are widely distributed in the body such as heart and brain. In vivo and in vitro experiments showed that unsaturated fatty acids may have effects of anti-inflammation, anti-oxidation, protecting vascular endothelial cells, thrombosis inhibition, modifying autonomic nerve function, improving left ventricular remodeling, and regulating blood lipid. Given the relevance to public health, there has been increasing interest in the research of potential cardioprotective effects of fish oil. Accumulated evidence showed that fish oil supplementation may reduce the risk of cardiovascular events, and, in specific, it may have potential benefits in improving the prognosis of patients with hypertension, coronary heart disease, cardiac arrhythmias, or heart failure; however, some studies yielded inconsistent results. In this article, we performed an updated systematical review in order to provide a contemporary understanding with regard to the effects of fish oil on cardiovascular diseases.

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Section: Anti-oxidation and Improved Endothelial Functionmentioning

confidence: 99%

The Effects of Fish Oil on Cardiovascular Diseases: Systematical Evaluation and Recent Advance

Liao

Xiong

Yin

et al. 2022

Front. Cardiovasc. Med.

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“…Studies on the combined effects of antioxidant-based nutritional supplements and exercise training on the redox status are not unequivocal. In both healthy and pathological rodent models, some studies found beneficial and synergistic effects [68], but not others [69]. Moreover, some studies demonstrated that their combination attenuates and blunts their individual actions [70].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

et al. 2021

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High-intensity interval training (HIIT) and linseed oil (LO) supplementation are effective strategies to reduce obesity-induced oxidative stress. Our aim was to determine whether the HIIT + LO combination prevents obesity-induced oxidative stress in high fat diet (HFD)-fed rats. HFD-fed 8-week-old, male, Wistar rats were subdivided in four groups: HFD, LO (2% of sunflower oil replaced with 2% of LO in the HFD), HIIT (4 days/week for 12 weeks), and HIIT + LO. Wistar rats fed a low-fat diet (LFD) were used as controls. Epididymal and subcutaneous adipose tissue, gastrocnemius muscle, liver, and plasma samples were collected to measure oxidative stress markers (AOPP, oxLDL), antioxidant (SOD, CAT, and GPx activities) and pro-oxidant (NOx and XO) enzyme activities. Compared with the LFD, the HFD altered the pro/antioxidant status in different tissues (increase of AOPP, oxLDL, SOD and catalase activities in plasma, and SOD activity increase in liver and decrease in adipose tissues) but not in gastrocnemius. LO upregulated CAT activity and decreased NOx in liver. HIIT alleviated HFD negative effects in liver by reducing SOD and NOx activities. Moreover, the HIIT + LO combination potentiated SOD activity upregulation in subcutaneous tissue. HIIT and LO supplementation have independent beneficial effects on the pro/antioxidant balance. Their association promotes SOD activity in subcutaneous adipose tissue.

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“…Similarly, maternal DHA supplementation during pregnancy is associated with decreased infant fat mass and increased lean body mass [ 13 ]. DHA and Eicosapentaenoic Acid (EPA) activate PPAR-α, which can inhibit expression of pro-inflammatory markers [ 14 ]. However, the potential influence of both maternal aerobic exercise and maternal polyunsaturated fatty acids (PUFAs) concentrations on infant body composition remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Maternal Aerobic Exercise, but Not Blood Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations, during Pregnancy Influence Infant Body Composition

Strom

McDonald

Remchak

et al. 2022

IJERPH

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Although discrete maternal exercise and polyunsaturated fatty acid (PUFA) supplementation individually are beneficial for infant body composition, the effects of exercise and PUFA during pregnancy on infant body composition have not been studied. This study evaluated the body composition of infants born to women participating in a randomized control exercise intervention study. Participants were randomized to aerobic exercise (n = 25) or control (stretching and breathing) groups (n = 10). From 16 weeks of gestation until delivery, the groups met 3×/week. At 16 and 36 weeks of gestation, maternal blood was collected and analyzed for Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA). At 1 month postnatal, infant body composition was assessed via skinfolds (SFs) and circumferences. Data from 35 pregnant women and infants were analyzed via t-tests, correlations, and regression. In a per protocol analysis, infants born to aerobic exercisers exhibited lower SF thicknesses of triceps (p = 0.008), subscapular (p = 0.04), SF sum (p = 0.01), and body fat (BF) percentage (%) (p = 0.006) compared with controls. After controlling for 36-week DHA and EPA levels, exercise dose was determined to be a negative predictor for infant skinfolds of triceps (p = 0.001, r2 = 0.27), subscapular (p = 0.008, r2 = 0.19), SF sum (p = 0.001, r2 = 0.28), mid-upper arm circumference (p = 0.049, r2 = 0.11), and BF% (p = 0.001, r2 = 0.32). There were no significant findings for PUFAs and infant measures: during pregnancy, exercise dose, but not blood DHA or EPA levels, reduces infant adiposity.

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Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats

Cited by 20 publications

References 40 publications

The Effects of Fish Oil on Cardiovascular Diseases: Systematical Evaluation and Recent Advance

The Effects of Fish Oil on Cardiovascular Diseases: Systematical Evaluation and Recent Advance

Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

Maternal Aerobic Exercise, but Not Blood Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations, during Pregnancy Influence Infant Body Composition

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