Supplementation of taurine and β-cyclodextrin to mice administered ethanol restores lipid metabolism and damaged liver

Shim, Kwan Seob; Kim, Sook Bae; Na, Chong Sam; Park, Garng Hee

doi:10.1016/j.nutres.2007.01.011

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…Indeed, supplementation with antioxidants as protection against ethanol-induced liver injury has been widely investigated. [7][8][9][10][11][12] Carnosine is a dipeptide having strong antioxidant effects. Antioxidant potential of carnosine was suggested to be dependent on its ability to inactivate reactive oxygen species, scavenge free radicals and chelate prooxidant metals.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] The oxidative stress induced by ethanol is a result of the production of free radical species during several stages of ethanol metabolism. [1][2][3] Several experimental [4][5][6][7][8][9][10][11][12] and clinical [13][14][15] studies have shown that ethanol ingestion alters the pro-oxidant-antioxidant balance in the organism. Therefore, the potential role of several substances such as antioxidants and thiol compounds has been investigated in ethanol-induced liver injury.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the potential role of several substances such as antioxidants and thiol compounds has been investigated in ethanol-induced liver injury. [7][8][9][10][11][12] Carnosine (b-alanyl-L-histidine) is a dipeptide commonly present in mammalian tissues. It has several functions such as membrane protecting activity, pHbuffering capacity and metal-chelating ability.…”

Section: Introductionmentioning

confidence: 99%

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The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats

et al. 2010

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Carnosine is a dipeptide having strong antioxidant effects. Oxidative stress plays an important role in pathogenesis of alcohol-induced liver injury. In this study, we investigated the effect of carnosine pretreatment on ethanol-induced oxidative stress and hepatotoxicity. Rats were given carnosine (2 g/L in drinking water) for 4 weeks and then ethanol was administered orally to rats at a dose of 5 g/kg every 12 hours for 3 doses totally (binge model). All rats were killed 6 hours after last ethanol injection. Plasma alanine (ALT) and aspartate (AST) transaminase activities and liver triglyceride, malondialdehyde (MDA), diene conjugate (DC), glutathione (GSH), vitamin E and vitamin C levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined. Binge ethanol administration resulted in significant increases in plasma transaminase activities, hepatic triglyceride and lipid peroxide levels. However, GSH, vitamin E, vitamin C levels and GSH-Px and GST activities were found to be decreased following ethanol administration. Macromicrovesicular steatosis was also seen. Carnosine pretreatment appeared to prevent the increase of plasma ALT and AST activities and hepatic MDA and DC levels following ethanol treatment. In addition, hepatic GSH levels increased, but there were no changes in triglyceride, vitamin E, vitamin C levels and SOD, GSH-Px and GST activities, following ethanol treatment in carnosine-pretreated rats. There was also no change in liver histopathological appearance. In conclusion, carnosine prevented the increases in serum transaminase activities and lipid peroxides in liver of ethanol-treated rats, without any change on steatosis in liver.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats

et al. 2010

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Taurine Content in Marine Foods: Beneficial Health Effects

Larsen¹,

Eilertsen²,

Mæhre³

et al. 2013

Bioactive Compounds From Marine Foods

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Cyclodextrins as therapeutic drugs for treating lipid metabolism disorders

Wu,

Li,

Shao

et al. 2024

Obesity Reviews

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SummaryObjectiveThis study sought to systematically compare the efficacy and mechanism of cyclodextrins as drug interventions in lipid metabolism diseases, potentially providing ideas for subsequent research directions and clinical applications.MethodsWe used the bibliometric method for feature mining, applied VOSviewer software for clustering analysis, and applied content analysis for objective descriptions and accurate analysis.Results(1) We collected more than 50 studies, which is the basic database of this study. (2) The academic bubble map showed that this research area was popular in the United States. (3) Cluster analysis showed that the intensively studied diseases in this field were Niemann–Pick type C (NPC), atherosclerosis (AS), and obesity. The hot‐spot cyclodextrin types were HP‐β‐CD. (4) Literature measurement revealed the involvement of 15 types of lipid metabolism diseases. Among them, NPC, diabetes, and obesity were studied in clinical trials. Dyslipidemia and AS have been reported relatively more frequently in animal experiments. The studies of cellular experiments provide insight into the molecular mechanisms that intervene in lipid metabolism diseases from multiple perspectives. The exploration of the molecular mechanisms by which cyclodextrins exert their pharmacological effects mainly revolves around lipid metabolism.ConclusionIt is worthwhile to investigate the role and mechanism of cyclodextrins in other lipid metabolism diseases. The potential efficacy evaluation of cyclodextrins as pharmaceutical drugs for oral or injectable formulations is less studied and may become a new focus in the future.

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Supplementation of taurine and β-cyclodextrin to mice administered ethanol restores lipid metabolism and damaged liver

Cited by 3 publications

References 25 publications

The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats

The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats

Taurine Content in Marine Foods: Beneficial Health Effects

Cyclodextrins as therapeutic drugs for treating lipid metabolism disorders

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