Supplementation with 2000 IU of Cholecalciferol Is Associated with Improvement of Trabecular Bone Mineral Density and Muscle Power in Pediatric Patients with IBD

Hradský, Ondřej; Souček, Ondřej; Maratová, Klara; Matysková, Jana; Copova, Ivana; Zárubová, Kristýna; Bronský, Jiří; Šumnı́k, Zdenĕk

doi:10.1097/mib.0000000000001047

Cited by 30 publications

(32 citation statements)

References 48 publications

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“…In IBD pediatric patients, 2000 IU/day of vitamin D 3 for 6 months was more effective in raising serum 25(OH)D concentrations > 30 ng/ml than 400 UI/day or doses up to 2000 IU of vitamin D 2 [ 407 , 408 ]. On the other hand, supplementation with 2000 IU/day of vitamin D 3 for 13.8 months improved trabecular BMD, cortical bone cross-sectional area, and maximal muscle power in 55 IBD patients [ 409 ].…”

Section: Extraskeletal Actions Of Vitamin Dmentioning

confidence: 99%

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

Vierucci²,

et al. 2018

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Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur.Besides its historical skeletal functions, in the last years it has been demonstrated that vitamin D directly or indirectly regulates up to 1250 genes, playing so-called extraskeletal actions. Indeed, recent data suggest a possible role of vitamin D in the pathogenesis of several pathological conditions, including infectious, allergic and autoimmune diseases. Thus, vitamin D deficiency may affect not only musculoskeletal health but also a potentially wide range of acute and chronic conditions. At present, the prevalence of vitamin D deficiency is high in Italian children and adolescents, and national recommendations on vitamin D supplementation during pediatric age are lacking. An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplementation to provide a practical approach to vitamin D supplementation for infants, children and adolescents.

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Section: Extraskeletal Actions Of Vitamin Dmentioning

confidence: 99%

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

Vierucci²,

et al. 2018

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“…60 In pediatric IBD patitents conflicting data have been reported. 61, 62 More systematic studies in pediatric and adult IBD patients need to be conducted to identify factors determining the clinical response to vitamin D and Ca 2+ supplementation, the form and route of administered vitamin D, with careful monitoring of the parameters of bone mass, bone turnover, and mineral homeostasis. The need for such systematic approach is further justified by identification of at least a subset of IBD patients with inappropriate hypercalcitriolemia (elevated serum 1,25(OH) 2 D 3 ).…”

Section: Vitamin D3 and Calciummentioning

confidence: 99%

Vitamins and Minerals in Inflammatory Bowel Disease

Ghishan

Kiela

2017

Gastroenterology Clinics of North America

106

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Indiscriminate use of multivitamin/mineral supplements in the general population may be misguided, but patients with chronic Inflammatory Bowel Diseases (IBD) should be monitored and compensated for nutritional deficiencies. Mechanistic links between vitamin/mineral deficiencies and IBD pathology has been found for some micronutrients and normalizing their levels is clinically beneficial. Others, like vitamin A, although instinctively desirable, produced disappointing results. Restoring normal levels of the selected micronutrients requires elevated doses to compensate for defects in absorptive or signaling mechanisms. This article describes some aspects of vitamin and mineral deficiencies in IBD, and summarizes pros and cons of supplementation.

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“…The cohort study of Hradsky et al[27] was designed to assess the effect of vitamin D 3 therapy on bone health parameters and dynamic muscle function. In total, 55 patients aged 5-19 years with a diagnosis of IBD were included.…”

Section: Resultsmentioning

confidence: 99%

“…Another study showed a similar response after weekly dosing of 50,000 IU D 3 for 6 wk[23]. In a third study, 2000 IU D 3 daily was able to achieve a mean s-25OHD above 30 ng/mL in the study population throughout the course of treatment[27]. Both 5000 IU/10 kg vitamin D 3 per week and 10000 IU/10 kg vitamin D 3 per week for a period of 6 wk were able to raise s-25OHD above 30 ng/mL at week 8 in one of the trials; however, this effect was lost by week 12[24].…”

Section: Discussionmentioning

confidence: 98%

Vitamin D therapy in children with inflammatory bowel disease: A systematic review

Rigterink

Appleton

Day

2019

WJCP

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BACKGROUNDVitamin D deficiency is highly prevalent in children with inflammatory bowel disease (IBD). This may contribute to an increased risk of poor bone health and may also influence the course of disease. An optimal treatment strategy of vitamin D therapy in children with IBD has not yet been established.AIMTo analyse the published intervention studies of vitamin D therapy in children with IBD.METHODSA systematic review was conducted of clinical studies involving children with IBD (including Crohn disease or ulcerative colitis) who had received vitamin D therapy. Studies up to March 31st 2018 were identified through MEDLINE, PubMed, EMBASE and the Cochrane Library. Search terms included synonyms of the following terms: vitamin D, paediatric, supplementation, IBD. References of included articles based on abstract were searched for other relevant articles. All relevant articles were accessed and reviewed in full text. Studies fitting the set criteria were included and the remainder were excluded.RESULTSTwo hundred and seventy-seven discrete articles were identified. Following assessment of these articles included in the initial search and application of inclusion and exclusion criteria, ten published studies were included in this review. The included studies showed a heterogeneity in study design, inclusion and exclusion criteria, baseline demographics and treatment strategies. Treatment regimens differed in length, supplemented form of vitamin D and factors based upon which dosage was adjusted. Each of the reports included in this review concluded their vitamin D regimens to be safe and well-tolerated. Few of the included studies reported secondary outcomes on the efficacy of vitamin D treatment upon the clinical course of disease or markers of inflammation. The majority of included trials were not sufficient in raising serum vitamin D levels to an adequate level (30 ng/mL) in children with IBD with vitamin D deficiency.CONCLUSIONThe included trials featured diverse treatment regimens that were predominantly insufficient in correcting vitamin D deficiency or maintaining adequate levels in children with IBD. Better treatment regimens are required for the management of vitamin D deficiency in children with IBD.

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Supplementation with 2000 IU of Cholecalciferol Is Associated with Improvement of Trabecular Bone Mineral Density and Muscle Power in Pediatric Patients with IBD

Abstract: We observed an improvement in bone and muscle parameters after cholecalciferol substitution in pediatric patients with IBD. Therefore, vitamin D substitution can be considered in such patients.

Cited by 30 publications

References 48 publications

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

Vitamins and Minerals in Inflammatory Bowel Disease

Vitamin D therapy in children with inflammatory bowel disease: A systematic review

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