Supplementation with CLA: Isomer incorporation into serum lipids and effect on body fat of women

Petridou, Anatoli; Mougios, Vassilis; Sagredos, A. N.

doi:10.1007/s11745-003-1129-2

Cited by 100 publications

(96 citation statements)

References 21 publications

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“…Smedman and Vessby (2001) showed that intake of 4.2 g CLA/day for 12 weeks did not affect serum lipid or lipoprotein concentrations. No effect on serum TG, TC, and HDL-C was again reported by Petridou et al (2003) when they studied the effect of supplementation of 2.1 g CLA/day for 45 days in non-obese young sedentary women.…”

Section: Cla and Lipidsmentioning

confidence: 82%

Biological effects of conjugated linoleic acids supplementation

Oleszczuk¹,

Oleszczuk²,

Siwicki³

et al. 2012

Polish Journal of Veterinary Sciences

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Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids (PUFA) with a single pair of conjugated double bonds. The major natural CLA isomer is 18:2 cis-9, trans-11 (c9, t11) linoleic acid, or rumenic acid (RA). Chemically synthesized CLA is also available, mostly as a mixture of RA and 18:2 trans-10, cis-12 (t10, c12) isomers in equal amounts (50:50). Consumption of ruminant meat (beef and lamb) and dairy products (milk and cheese) is the main source of dietary exposure to CLA. Despite numerous studies on animal and human models (tumorigenesis, obesity, immune response) it has not been established whether additional supplementation of CLA is of benefit. Moreover, some studies, conducted both in animals and in humans, reveal that CLA isomers may induce insulin resistance. Presently, balanced diet rich in CLA from natural sources is recommended. The purpose of this review was to sum up the results available in the literature.

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Section: Cla and Lipidsmentioning

confidence: 82%

Biological effects of conjugated linoleic acids supplementation

Oleszczuk¹,

Oleszczuk²,

Siwicki³

et al. 2012

Polish Journal of Veterinary Sciences

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“…A 6.4 g day 21 MI-CLA doses for 12 weeks produced a modest increase in lean mass (0.6 kg) but significant decrease in serum HDL-cholesterol, sodium, hemoglobin, and hematocrit, and significant increases in serum alkaline phosphatase, C-reactive protein, and K-6, and white blood cells. Plasma triacylglycerides (TAG) did not significantly change or decrease compared to placebo in some studies with MI-CLA supplementation 33,59,62,63 . Nevertheless, in another study mean plasma TAG concentration was higher during supplementation with a mixture 85% trans-10,cis-12 CLA than with another mixture 80% cis-9,trans-11 CLA 24 .…”

Section: Metabolic Effects Of Conjugated Linoleic Acidmentioning

confidence: 99%

Conjugated linoleic acid (CLA) and obesity

Silveira

Carraro

Monereo

et al. 2007

Public Health Nutr.

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Background: The term conjugated linoleic acid (CLA) refers to several positional and geometric conjugated dienoic isomers of linoleic acid (LA), of which the trans-10,cis-12 isomer has been reported to reduce adiposity and increase lean mass in mice and other animals when included at #1% of the diet. However, most dietary CLA in humans is obtained from dairy products, accounting for the cis-9,trans-11 CLA isomer, also known as rumenic acid, for more than 90% of the total CLA intake. Commercial CLA preparations industrially produced, containing trans-10,cis-12 and cis-9,trans-11 CLA isomers in diverse proportions, are attracting consumers' interest because of the purported body fat-lowering effects of CLA, coupled to the perception of a 'natural' compound devoid of harmful effects. Nevertheless, despite numerous studies on CLA effects on body composition for nearly a decade, the mechanisms by which CLA isomers elicit their effects remain largely unknown. The purpose of this paper is to provide an updated review of the studies performed on animals and humans, as well as to describe the potential mechanisms involved in CLA effects on body weight and composition and metabolism. Method: Literature review. Results: Experiments in humans have not been able to show a significant effect on body weight, body composition or weight regain related to either of the CLA isomers. In fact, some studies suggest a tendency towards a decrease in body fat mass and an increase in body lean mass, while some others raise concern about the possibility of deleterious effects of trans-10,cis-12 CLA on lipid profile, glucose metabolism and insulin sensitivity. Conclusions: Evidence regarding effectiveness of CLA in humans is not concluding.

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“…(2003) (16) Sixteen females, healthy sedentary normal-weight and overweight (19) Sixty males and females, healthy overweight…”

Section: Conjugated Linoleic Acid Supplementation and Ldl Cholesterolmentioning

confidence: 99%

Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis

Derakhshande-Rishehri

Mansourian

Kelishadi

et al. 2014

Public Health Nutr.

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Objective: The present study aimed to review the association of conjugated linoleic acid (CLA) consumption in two forms, foods enriched in CLA and CLA supplements, with serum lipid profile in human studies. Design: Systematic review and meta-analysis. Setting: Search process was conducted in PubMed, Cochrane Library, Google Scholar, Scopus and Science Direct. Clinical trials that investigated the association of CLA intakes either in the form of supplements or enriched foods with lipid profile in healthy adults were included. All outcomes were recorded as continuous variables, and the effect size was measured by analysis of the mean and standard deviation before and after the intervention for case and control groups. Subjects: Healthy adult population. Results: CLA supplementation was associated with a significant decrease in LDL cholesterol (mean difference = − 0·218; 95 % CI − 0·358, − 0·077; P = 0·002), a nonsignificant decrease in HDL cholesterol (mean difference = − 0·051; 95 % CI − 0·188, 0·086; P = 0·468), a non-significant increase in total cholesterol (mean difference = 0·009; 95 % CI − 0·128, 0·146; P = 0·896) and a non-significant decrease in TAG (mean difference = − 0·065; 95 % CI − 0·20, 0·07; P = 0·344). Foods enriched with CLA were associated with significantly decreased LDL cholesterol (mean difference = − 0·231; 95 % CI − 0·438, − 0·024; P = 0·028), non-significantly increased HDL-C (mean difference = 0·075; 95 % CI − 0·121, 0·270; P = 0·455), non-significantly decreased total cholesterol (mean difference = − 0·158; 95 % CI − 0·349, 0·042; P = 0·124) and non-significantly decreased TAG (mean difference = − 0·078; 95 % CI − 0·274, 0·117; P = 0·433). Conclusions: According to our analysis, consumption of foods enriched with CLA or CLA supplements has favourable effects on LDL cholesterol levels.

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Supplementation with CLA: Isomer incorporation into serum lipids and effect on body fat of women

Cited by 100 publications

References 21 publications

Biological effects of conjugated linoleic acids supplementation

Biological effects of conjugated linoleic acids supplementation

Conjugated linoleic acid (CLA) and obesity

Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis

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