Supplementation with Fetal-Specific Factors Ameliorates Oxidative Liver Damage During Hypothermic Storage and Reperfusion in a Rat Model

Functional hepatic recovery after xenotransplantation of cryopreserved fetal liver cells or soluble cell‐factor administration in a cirrhotic rat model: Are viable cells necessary?

“…Intrasplenic injection of both FLC and FSF prevented animal mortality to an equal extent and almost completely normalized TBARS content in blood serum; this confirms the role of free radical processes in lesions induced by chronic CCl 4 administration, 28,29 and indicates that living cell activity is not necessary for this process of repair against free radical damage. In fact, we have recently shown that FSF pretreatment can enhance liver antioxidant defenses in a model of hepatic cold preservation and reperfusion, supporting the evidence that a strong protective effect resides within the soluble factors in the FSF extract 30 …”

“…In fact, we have recently shown that FSF pretreatment can enhance liver antioxidant defenses in a model of hepatic cold preservation and reperfusion, supporting the evidence that a strong protective effect resides within the soluble factors in the FSF extract. 30 Two weeks after intrasplenic injection in both the FLC and FSF groups, there were morphological signs testifying to the activation of recovery processes in the cirrhotic livers. Appearance of foci of visible repair was accompanied by the considerable recovery of liver function shown by the biochemical indices.…”

Organ Preservation: Current Concepts and New Strategies for the Next Decade

“…One more important feature of these cells is their resistance to hypoxia [154], which in theory should be supported by appropriate regulatory and growth factor mechanisms. Our studies on rats showed that pretreatment with cytosol of human foetal tissues of mesenchymalmesodermal origin led to almost total normalisation of the liver pro-oxidant/anti-oxidant balance during 24 h of cold hepatic storage and following warm re-perfusion [155]. Also, we ob-…”

Hepatoprotective effect of fetal tissue cytosol and its thermostable fraction in rats with carbon tetrachloride-induced hepatitis

“…FTC was isolated by highspeed staged ultracentrifugation (protein content 1.0±0.2 mg/ml) [5]. TSF was obtained as described previously [7].…”