Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid

Allaire, Janie; Harris, William S.; Vors, Cécile; Charest, Amélie; Marín, Javier; Jackson, Kristina Harris; Tchernof, André; Couture, Patrick; Lamarche, Benoı̂t

doi:10.1016/j.plefa.2017.03.008

Cited by 56 publications

(42 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,23 Regarding the EPA (20:5n-3), content between 90.2-162.1 mg g -1 were found in samples 1-11, except for sample 6, in which 120.2 mg g -1 was found; 273.0 and 440.3 mg g -1 were found in samples 12 and 13, respectively; in samples 14 and 15, which presented high levels of LA, 2.6 and 3.4 mg g -1 were found, respectively; EPA was N.D. in soybean oil. It was also observed for docosapentaenoic acid (DPA, 22:5n-3) fatty acid, for which content was found in the range of 12.9-23.2 mg g -1 in samples 1-11, except for sample 6 in which 15.9 mg g -1 was found; 39.8 mg g -1 was Allaire et al 2 reported that an increase of EPA + DHA in red blood cell membranes (O3I, omega-3 index) was observed with the consumption of supplements with high doses of DHA, compared with EPA, and O3I has already been associated with lower risk of coronary heart disease. It is important to note that, excluding sample 7, the analyzed samples (which were sources of EPA and DHA) were more concentrated in EPA than DHA.…”

Section: Fatty Acid Compositionmentioning

confidence: 77%

“…12 Therefore, 12 fatty acids were quantified in the lipid material present in capsules of omega-3 supplements (samples [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], and the results are presented in Table 2. Among them, samples 14 and 15 (both of Brazilian origin) were distinctive in composition compared to the other omega-3 supplements since they presented low levels of EPA and DHA, and high levels of linoleic acid (LA, 18:2n-6).…”

Section: Fatty Acid Compositionmentioning

confidence: 99%

“…Clinical studies have demonstrated that their consumption, especially eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), decreases the risk of chronic diseases. 1 Furthermore, it is known that EPA and DHA can adjust cardiometabolic risk factors, 2 have beneficial effects in the immune system, neurodegenerative disturbances, on some cancers, 3 as well as being effective in reducing symptoms related to depression. 4 EPA and DHA are almost exclusively found in marine products, 5 fish oil being the main source of these compounds.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quality Assessment of Omega-3 Supplements Available in the Brazilian Market

Galuch¹,

Carbonera²,

Magon³

et al. 2017

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Omega-3 fish oil supplements are widely consumed as source of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, presenting beneficial effects on human health. This study aimed to evaluate fifteen brands of omega-3 fish oil supplements available in Brazilian market in order to estimate the Brazilian reality regarding those supplements. Twelve fatty acids were quantified by gas chromatography with a flame ionization detector (GC-FID), and lipid profile were obtained via mass spectrometry fingerprinting using direct electrospray ionization mass spectrometry (ESI-MS) to assess the form in which fatty acids are present as well as the possible fraud existence. Among all analyzed samples, thirteen brands were revealed as EPA and DHA sources (90.2-440.3 and 77.8-302.3 mg g -1 lipid, respectively) in triacylglycerols (TAG) or ethyl esters (EE) form. However, two brands were discovered with addition of large amounts of soybean oil, leading the final consumer to ingest this low-cost oil believing that they are consuming adequate doses of EPA and DHA.

show abstract

Section: Fatty Acid Compositionmentioning

confidence: 77%

Section: Fatty Acid Compositionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quality Assessment of Omega-3 Supplements Available in the Brazilian Market

Galuch¹,

Carbonera²,

Magon³

et al. 2017

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…Although both Japanese and American take meat, egg, and fish, fish has far more omega-3 fatty acids compared to eggs. When we eat larger amounts of omega-3 fatty acids such as DHA and EPA, omega-3 fatty acids are known to replace omega-6 fatty acids in cell membrane [36]. The omega-3 fatty acids are found predominantly in oily fish, whereas arachidonic acid (the major long chain omega-6 fatty acid) is contained in meats and eggs and can be synthesized (albeit very slowly) [37].…”

Section: Discussionmentioning

confidence: 99%

Roles of Trans and ω Fatty Acids in Health; Special References to Their Differences Between Japanese and American Old Men

Takada¹,

Shimizu²,

Koba³

2019

Visions of Cardiomyocyte - Fundamental Concepts of Heart Life and Disease [Working Title]

View full text Add to dashboard Cite

Omega and trans-fatty acids play important roles in atherogenesis of vascular system. In this review, we discuss such roles in health; there are much differences in coronary heart disease (CHD) rates between the US and Japan. Fatty acids profiles in the plasma are related to risks of CHD. There have been few studies that compared plasma levels of fatty acids, including trans-fatty acids, in people in Japan and the US. Plasma levels of long-chain omega-3 fatty acids (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) were higher in Japanese men, and omega-6 fatty acids (e.g., arachidonic acid [AA]) were lower compared with American men. American people had higher plasma levels of the major industrially produced trans-fatty acids (IP-TFAs; elaidic and inoelaidic acids), and levels of the potentially cardioprotective, primarily ruminant-derived trans-fatty acid, palmitoelaidic acid (POA) were higher in Japanese men. Plasma levels of saturated or monounsaturated fatty acids were also higher in American men. Only intakes of preference drinks have significant correlation with plasma levels of palmitoelaidic acid and linoelaidic acid. The higher levels of DHA and EPA, along with the lower levels of the IP-TFAs, are consistent with the markedly lower risk for coronary heart disease in Japan vs. the US.

show abstract

“…In adipose tissue, EPA-supplemented groups exhibited a down-regulation of ADGRE1 (0 (49) . EPA promoted changes in extracellular matrix remodelling gene expression in adipose tissue (50) Allaire et al (51,52) and Vors et al v. EPA, P < 0•0001) (52) . EPA and DHA have similar effects on the expression of many inflammation-related genes in immune cells (53) ↓, Decrease.…”

Section: Obesity Treatmentmentioning

confidence: 98%

n-3 PUFA and obesity: from peripheral tissues to the central nervous system

et al. 2018

View full text Add to dashboard Cite

The current paradigms of prevention and treatment are unable to curb obesity rates, which indicates the need to explore alternative therapeutic approaches. Obesity leads to several damages to the body and is an important risk factor for a number of other chronic diseases. Furthermore, despite the first alterations in obesity being observed and reported in peripheral tissues, studies indicate that obesity can also cause brain damage. Obesity leads to a chronic low-grade inflammatory state, and the therapeutic manipulation of inflammation can be explored. In this context, the use of n-3 PUFA (especially in the form of fish oil, rich in EPA and DHA) may be an interesting strategy, as this substance is known by its anti-inflammatory effect and numerous benefits to the body, such as reduction of TAG, cardiac arrhythmias, blood pressure and platelet aggregation, and has shown potential to help treat obesity. Thereby, the aim of this narrative review was to summarise the literature related to n-3 PUFA use in obesity treatment. First, the review provides a brief description of the obesity pathophysiology, including alterations that occur in peripheral tissues and at the central nervous system. In the sequence, we describe what are n-3 PUFA, their sources and their general effects. Finally, we explore the main topic linking obesity and n-3 PUFA. Animal and human studies were included and alterations on the whole organism were described (peripheral tissues and brain).

show abstract

Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid

Cited by 56 publications

References 28 publications

Quality Assessment of Omega-3 Supplements Available in the Brazilian Market

Quality Assessment of Omega-3 Supplements Available in the Brazilian Market

Roles of Trans and ω Fatty Acids in Health; Special References to Their Differences Between Japanese and American Old Men

n-3 PUFA and obesity: from peripheral tissues to the central nervous system

Contact Info

Product

Resources

About