Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne

Abstract

Systemic supplementation with probiotics is increasingly being explored as a potential treatment strategy for skin disorders. Because both the gut-skin axis and dysregulation of insulin signalling have been implicated in the pathogenesis of adult acne, we designed the current study to evaluate the effect of supplementation with the probiotic strain Lactobacillus rhamnosus GG (LGG) on skin expression of genes involved in insulin signalling and acne improvement in adult subjects. A pilot, randomized, double-blinded, placebo-controlled study was conducted with 20 adult subjects (14 females and 6 males; mean age: 33.7 ± 3.3 years) with acne. Over a 12-week period, the probiotic group (n = 10) consumed a liquid supplement containing LGG at a dose of 3×10 9 CFU/day (75 mg/day), whereas the placebo group (n = 10) received a liquid lacking probiotics. Paired skin biopsies -one obtained before treatment initiation and one obtained at the end of the 12-week treatment period -were analyzed for insulin-like growth factor 1 (IGF1) and forkhead box protein O1 (FOXO1) gene expression.The clinical criterion for efficacy was the investigator's global improvement rating on a fivepoint scale. Compared with baseline, the probiotic group showed a 32% (P<0.001) reduction as well as a 65% increase (P<0.001) in IGF1 and FOXO1 gene expression in the skin, respectively. No such differences were observed in the placebo group. Patients in the probiotic group had an adjusted odds ratio of 28.4 (95% confidence interval = 2.2−411.1, P<0.05) to be rated by physicians as improved/markedly improved (versus worsened or unchanged) compared with the placebo group. We conclude that supplementation with the probiotic strain LGG normalizes skin expression of genes involved in insulin signalling and improves the appearance of adult acne.

<b><i>Staphylococcus epidermidis</i></b>: A Potential New Player in the Physiopathology of Acne?

“…These observations raise hope that the right kind of bacteria may have beneficial effects on the skin homoeostasis, skin inflammation, and peripheral tissue responses to perceived stress. Other studies conducted in humans confirmed this hypothesis [76-78]. Thus, probiotics may be efficient in acne and other inflammatory skin diseases such as atopic dermatitis and potentially psoriasis [79-83].…”

The influence of exposome on acne

“…Very few controlled studies have investigated the benefit of oral probiotics in the treatment of acne. When compared to the placebo in 20 patients, the probiotic containing Lactobacillus rhamnosus SP1 provided a better clinical outcome according to the investigators . An adjunctive supplementation of lyophilized Lactobacillus acidophilus and Bifidobacterium bifidum adjunctively to standard antibiotics improved acne in 40 patients .…”

Forkhead Box Protein O1 is Linked to Anti-Inflammatory Probiotic Bacteria Acting through Nuclear Factor-κB Pathway

“…The transcription factor FoxO1 has been related to the response of probiotics in C. elegans oxidative stress, skin acne and alcoholic fatty liver [22,45,46]. Nevertheless, this is the first study linking FoxO1 activation to probiotics response in intestinal mammalian cells.…”