Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy

Benedetto, Fernando De; Pastorelli, Roberta; Ferrario, Manuela; Blasio, Francesca de; Marinari, Stefano; Brunelli, Laura; Wouters, Emiel F.M.; Polverino, Francesca; Celli, Bartolomé R.

doi:10.1016/j.rmed.2018.08.002

Cited by 34 publications

(42 citation statements)

References 81 publications

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“…Few clinical trials have been carried out to study the effects of CoQ 10 supplementation as an antioxidant counteracting the oxidative stress in the basis of the disease. DeBenedetto et al demonstrated in a randomized study that 2-months’ supplementation with QTer ® (a formulation for CoQ 10 ) and creatine significantly improved exercise capacity, body composition, dyspnea, and daily activities, and was associated with positive changes in the plasma metabolic profile in COPD patients on long-term oxygen therapy [ 75 ]. However, since the combined use with creatine, it is difficult to attribute all the beneficial outcomes observed by the authors to only the action of QTer ® , mainly the improvement in the exercise capacity and the daily activities, since creatine contribute to a better metabolism in the muscle function.…”

Section: Coq 10 and Chronic Obstructive Pulmonamentioning

confidence: 99%

Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

Gutiérrez-Mariscal

Larriva

Pérez

et al. 2020

IJMS

116

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Apart from its main function in the mitochondria as a key element in electron transport, Coenzyme Q10 (CoQ10) has been described as having multiple functions, such as oxidant action in the generation of signals and the control of membrane structure and phospholipid and cellular redox status. Among these, the most relevant and most frequently studied function is the potent antioxidant capability of its coexistent redox forms. Different clinical trials have investigated the effect of CoQ10 supplementation and its ability to reduce oxidative stress. In this review, we focused on recent advances in CoQ10 supplementation, its role as an antioxidant, and the clinical implications that this entails in the treatment of chronic diseases, in particular cardiovascular diseases, kidney disease, chronic obstructive pulmonary disease, non-alcoholic fatty liver disease, and neurodegenerative diseases. As an antioxidant, CoQ10 has proved to be of potential use as a treatment in diseases in which oxidative stress is a hallmark, and beneficial effects of CoQ10 have been reported in the treatment of chronic diseases. However, it is crucial to reach a consensus on the optimal dose and the use of different formulations, which vary from ubiquinol or ubiquinone Ubisol-Q10 or Qter®, to new analogues such as MitoQ, before we can draw a clear conclusion about its clinical use. In addition, a major effort must be made to demonstrate its beneficial effects in clinical trials, with a view to making the implementation of CoQ10 possible in clinical practice.

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Section: Coq 10 and Chronic Obstructive Pulmonamentioning

confidence: 99%

Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

Gutiérrez-Mariscal

Larriva

Pérez

et al. 2020

IJMS

116

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“…Recently, more attention has been paid to the effects of nutritional supplementation. Researchers have found that compared with the combination treatment of long-term oxygen therapy (LTOT) and placebo, LTOT coupled with nutritional supplementation of CoQ10 and creatine could markedly improve the lung function and symptoms of COPD patients [22]. Metabolites associated with glycerophospholipid and amino acid metabolism had significant differences between the two groups.…”

Section: Copd-associated Biomarkers In Different Sample Types and mentioning

confidence: 99%

“…The main function of creatine is to provide phosphate groups for the conversion from adenosine diphosphate to ATP [102]. Several studies also reported that creatine might protect lung function from oxidative stress damage by reducing superoxide anions and peroxynitrite [22]. The β-oxidation process of long chain fatty acids in the mitochondria depends on the transport of a vital antioxidant, L-carnitine [103].…”

Section: The Role Of Metabolism Dysfunction In Copd Pathogenesismentioning

confidence: 99%

An Updated Overview of Metabolomic Profile Changes in Chronic Obstructive Pulmonary Disease

Ran

Pang

et al. 2019

Metabolites

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Chronic obstructive pulmonary disease (COPD), a common and heterogeneous respiratory disease, is characterized by persistent and incompletely reversible airflow limitation. Metabolomics is applied to analyze the difference of metabolic profile based on the low-molecular-weight metabolites (<1 kDa). Emerging metabolomic analysis may provide insights into the pathogenesis and diagnosis of COPD. This review aims to summarize the alteration of metabolites in blood/serum/plasma, urine, exhaled breath condensate, lung tissue samples, etc. from COPD individuals, thereby uncovering the potential pathogenesis of COPD according to the perturbed metabolic pathways. Metabolomic researches have indicated that the dysfunctions of amino acid metabolism, lipid metabolism, energy production pathways, and the imbalance of oxidations and antioxidations might lead to local and systematic inflammation by activating the Nuclear factor kappa-light-chain-enhancer of activated B cells signaling pathway and releasing inflammatory cytokines, like interleutin-6 (IL-6), tumor necrosis factor-α, and IL-8. In addition, they might cause protein malnutrition and oxidative stress and contribute to the development and exacerbation of COPD.

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“…Therefore, given its capture of gene function, enzyme activity and physiologic changes, the study of metabolomics has the potential to inform the clinical heterogeneity of COPD phenotypes. While human studies conducted to date have showed that metabolomics analysis of the serum, plasma, urine and exhaled breath condensate can discriminate between never smokers, smokers with COPD and smokers without COPD 7–11 , the relationship between metabolic profiles and the clinical heterogeneity of COPD has not yet been fully characterized.…”

Section: Introductionmentioning

confidence: 99%

Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study

Labaki

Murray

et al. 2019

Sci Rep

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Metabolomics is an emerging science that can inform pathogenic mechanisms behind clinical phenotypes in COPD. We aimed to understand disturbances in the serum metabolome associated with respiratory outcomes in ever-smokers from the SPIROMICS cohort. We measured 27 serum metabolites, mostly amino acids, by 1 H-nuclear magnetic resonance spectroscopy in 157 white ever-smokers with and without COPD. We tested the association between log-transformed metabolite concentrations and one-year incidence of respiratory exacerbations after adjusting for age, sex, current smoking, body mass index, diabetes, inhaled or oral corticosteroid use, study site and clinical predictors of exacerbations, including FEV 1 % predicted and history of exacerbations. The mean age of participants was 53.7 years and 58% had COPD. Lower concentrations of serum amino acids were independently associated with 1-year incidence of respiratory exacerbations, including tryptophan (β = −4.1, 95% CI [−7.0; −1.1], p = 0.007) and the branched-chain amino acids (leucine: β = −6.0, 95% CI [−9.5; −2.4], p = 0.001; isoleucine: β = −5.2, 95% CI [−8.6; −1.8], p = 0.003; valine: β = −4.1, 95% CI [−6.9; −1.4], p = 0.003). Tryptophan concentration was inversely associated with the blood neutrophil-to-lymphocyte ratio (p = 0.03) and the BODE index (p = 0.03). Reduced serum amino acid concentrations in ever-smokers with and without COPD are associated with an increased incidence of respiratory exacerbations.

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Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy

Cited by 34 publications

References 81 publications

Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

An Updated Overview of Metabolomic Profile Changes in Chronic Obstructive Pulmonary Disease

Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study

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