Green supply chain management (GSCM) has proven itself to be pivotal, including in the hospitality and hotel industries. Additionally, organizations cannot become eco-friendly without applying GSCM. Applying GSCM is very complicated due to the complex nature of the management relations with stakeholders involved and needs appropriate support and collaboration from all related parties in order to accomplish the wanted management results. This paper aimed to analyze and study the complicated roles and relations of GSCM and the hotel industry, identifying the main barriers that might be faced in its application and trying to present the full picture in a simple and comprehensive way in order to provide decision-makers with a wider vision. This can then be used to take the best actions. The analysis technique this study adopted to use to analyze the related scientific production was a systematic review technique. After the screening and cleaning processes, a total of 57 GSCM articles remained from the articles, which were extracted from scientific databases (WoS and Scopus) and analyzed using the three main levels of analysis groups. This study revealed that: (i) GSCM interferences and relations can be summarized into six main categories (external stakeholders, internal stakeholders, related management, the 4Rs, innovation and technology, and performance); (ii) the importance of GSCM goes beyond environmental objectives; and (iii) before applying GSCM practices, there are a number of primary barriers that should be considered regarding the hotel industry.