Supported and Suspended 2D Material-Based FET Biosensors

Masurkar, Nirul; Varma, Sundeep; Arava, Leela Mohana Reddy

doi:10.3390/electrochem1030017

“…[ 12 ]); ( top right ) schematic diagram of a field effect transistor (FET)-based biosensor with a source and drain (Reprinted with permission from Ref. [ 13 ]); ( bottom left ) schematic diagram of optical biosensor constitution (Reprinted with permission from Ref. [ 14 ]); ( bottom right ) the main constituents of a nanomaterial-based electrochemical biosensor (Reprinted with permission from Ref.…”

Section: Types Of Biosensors Used For Virus Detectionmentioning

confidence: 99%

Decadal Journey of CNT-Based Analytical Biosensing Platforms in the Detection of Human Viruses

Sengupta¹,

Hussain

²

2022

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It has been proven that viral infections pose a serious hazard to humans and also affect social health, including morbidity and mental suffering, as illustrated by the COVID-19 pandemic. The early detection and isolation of virally infected people are, thus, required to control the spread of viruses. Due to the outstanding and unparalleled properties of nanomaterials, numerous biosensors were developed for the early detection of viral diseases via sensitive, minimally invasive, and simple procedures. To that aim, viral detection technologies based on carbon nanotubes (CNTs) are being developed as viable alternatives to existing diagnostic approaches. This article summarizes the advancements in CNT-based biosensors since the last decade in the detection of different human viruses, namely, SARS-CoV-2, dengue, influenza, human immunodeficiency virus (HIV), and hepatitis. Finally, the shortcomings and benefits of CNT-based biosensors for the detection of viruses are outlined and discussed.

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“…FET-based biosensors with 1-D Nanowires and CNTs as channel material have a significant advantage over label-based detection 10 because they exhibit good electrostatics between biomolecules and the channel, resulting in increased sensitivity. However, synthesizing biosensors that meet all of these criteria at the same time has proven difficult, as 0-D and 1-D nanomaterials-based biosensors are difficult to fabricate on a large scale and have high production costs 11 – 13 , limiting the practical feasibility of such structures.…”

Section: Introductionmentioning

confidence: 99%

“…After that many dielectric-modulated FET-based biosensors have been reported with the enhancement in sensitivity [5][6][7][8][9] .FET-based biosensors with 1-D Nanowires and CNTs as channel material have a significant advantage over label-based detection 10 because they exhibit good electrostatics between biomolecules and the channel, resulting in increased sensitivity. However, synthesizing biosensors that meet all of these criteria at the same time has proven difficult, as 0-D and 1-D nanomaterials-based biosensors are difficult to fabricate on a large scale and have high production costs [11][12][13] , limiting the practical feasibility of such structures.Contrarily, tremendous progress has recently been made with Transition Metal Dichalcogenides (TMDs), one of the most intriguing 2-D semiconducting materials for next-generation biosensors. Because of their excellent electrostatic control, planar nature, high surface-to-volume ratio, superior charge sensitivity, and high electron mobility, among other advantage, TMDs hold a lot of promise for use as a channel in FET-based ultra-sensitive biosensors 12,14 .…”

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confidence: 99%

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A detailed investigation of dielectric-modulated dual-gate TMD FET based label-free biosensor via analytical modelling

Kumari

¹

,

Singh

²

,

Sahoo

³

2022

Sci Rep

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In this work, an analytical model is developed for DM-DG-TMD-FET- based Biosensor including Fringing-field effects. The Analytical model has been developed for two different Device structures, namely Device structure-1 (without a gate above the nano-cavity) and Device structure-2 (with a gate above the nano-cavity) based on modulation of the dielectric constant of biomolecules in the nano-cavity region. The proposed model has been validated against both numerical quantum simulation results with the help of a few fitting parameters and it also agrees with the 2-dimensional numeric simulator SILVACO TCAD used in this work. The presence/absence of biomolecules has been detected by the metric of threshold voltage sensitivity $$S_{Vth}$$ S Vth and drain current $$I_{d}$$ I d for the neutral as well as charged biomolecules. Sensitivities of partially filled nano-cavities arising out of steric hindrance in both the biosensors are compared. Optimization of device dimensions has also been included in this work to enhance the sensitivity of the biosensors. It has been witnessed that the sensitivity of the proposed biosensor is $$\sim$$ ∼ 100% higher in Device structure-1 for neutral biomolecules with dielectric constant $$\kappa$$ κ = 12, when compared to Device structure-2 for fully filled cavities. Whereas for the charged biomolecules, Device structure-1 shows $$\sim$$ ∼ 50% enhanced sensitivity than Device structure-2 for $$N_{f}=-1\times 10^{-12}$$ N f = - 1 × 10 - 12 $$\text{C}/\text{cm}^2$$ C / cm 2 . Device structure-1 demonstrates $$\sim$$ ∼ 120% higher sensitivity than Device structure-2 with partially filled cavities (i.e. 66% filled cavity). Finally, benchmarking of the proposed biosensor is presented with contemporary, state-of-the-art biosensors and it is highlighted that $$MoS_{2}$$ M o S 2 FET-based biosensor emerges with a superior sensitivity of $$S_{Vth}$$ S Vth = 0.81 V for $$\kappa = 12$$ κ = 12 .

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“…Due to that schottky tunneling mechanism is preferred, the schottky barrier (SB)-FET modi ed the restriction and drops the short channel effect [6][7][8]. Later, SB-FET-based biosensor has appeared as an appropriate applicant for improved sensitivity and response time than MOSFET-based biosensor [9][10][11]. The simple working of a Schottky barrier (SB) eld-effect transistor (FET) conventional biosensor is to moderate the electrical properties with gate bias over the combination of objective biomolecules, then calculating the improved electrostatic enactment limitations.…”

Section: Introductionmentioning

confidence: 99%

Performance Analysis of Double Gate Dielectric Modulation in Schottky FET as Biomolecule Sensor

Kumar

¹

2021

Silicon

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In this article, a charge-plasma (CP)-based double gate schottky barrier FET structure has been investigated using dielectric controlled biomolecule sensor. The use of Hafnium as a charge plasma at the source side encourages an n+ charge plasma in an un-doped silicon region, which expressively decreases the Schottky barrier thickness. The oxide below the Metal gate M 1 and M 2 is etched out to create nanogap openings for biomolecule nding. Here, the existence of molecules is categorized by the modi cation in oxide material inside the nanogap and the related charge densities, hence, to controls the tunneling thickness at the Metal-source-silicon channel interface, also with the help of plasma charges in an intrinsic-Si lm. This paper is mainly focused on the fundamental physics of the proposed structure and approximations of their relative sensitivity detecting enactment. The sensing enactment has been assessed for charged biomolecules and charge-neutral biomolecules by widespread device simulation, and the special properties of the biomolecule. The proposed device improves its control over the tunneling region and this has been used for the sensing, ensuing to larger on-state drain current (I ds ) sensitivity for biomolecule. Hence, the gate voltage is recognised as the active design parameters for e cient reduction. Moreover, the sensing of the SB FET-based biosensor threshold voltage (V th ), abnormality in the on-current (Ion), and Ion/Ioff ratio has been shown. Also, the charge-plasma (CP)based double gate schottky barrier FET simulations calibrated with experimental results. Hence, the relative change in Ion using charge-plasma (CP)-based double gate schottky barrier FET biosensor maintain improved detecting ability for biomolecule recognition.

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Supported and Suspended 2D Material-Based FET Biosensors

Cited by 19 publications

References 105 publications

Decadal Journey of CNT-Based Analytical Biosensing Platforms in the Detection of Human Viruses

Decadal Journey of CNT-Based Analytical Biosensing Platforms in the Detection of Human Viruses

A detailed investigation of dielectric-modulated dual-gate TMD FET based label-free biosensor via analytical modelling

Performance Analysis of Double Gate Dielectric Modulation in Schottky FET as Biomolecule Sensor

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