Supported Hybrid Enzyme-Organocatalysts for Upgrading the Carbon Content of Alcohols

Abstract

A bicatalytic system was prepared by the immobilization of alcohol oxidase enzyme and an alkylamine organocatalyst in distinct locations of mesoporous nanoparticles. The resulting nanocomposites were able to perform a sequence of oxidation and aldol coupling reactions, which transformed short chain alcohols into longer chain molecules. The process takes place at low temperatures, but requires additional enzyme (catalase) to prevent inactivation of the catalyst. This qualitative study introduces a model of a hybrid multicomponent nanomaterial that resembles the behavior of multienzymatic systems within confined spaces. Disciplines Chemistry CommentsReprinted (adapted) with permission from ACS Symposium Series 1132 (2013) A bicatalytic system was prepared by the immobilization of alcohol oxidase enzyme and an alkylamine organocatalyst in distinct locations of mesoporous nanoparticles. The resulting nanocomposites were able to perform a sequence of oxidation and aldol coupling reactions, which transformed short chain alcohols into longer chain molecules. The process takes place at low temperatures, but requires additional enzyme (catalase) to prevent inactivation of the catalyst. This qualitative study introduces a model of a hybrid multicomponent nanomaterial that resembles the behavior of multienzymatic systems within confined spaces.

Co-immobilization of enzymes with the help of a dendronized polymer and mesoporous silica nanoparticles

“…6). For possible applications, the GOD stability may be increased by using other particles, possibly functionalized, 53,54 which in the past have shown to be excellent hosts for GOD. [55][56][57][58][59][60] Whether the general concept of enzyme co-immobilization elaborated in the present work can also be applied to other enzymatic cascade systems remains to be seen.…”