Suppressed antibody and interleukin-6 responses to acute pyelonephritis in pregnancy

Petersson, C. Leon M.; Hedges, Spencer R.; Stenqvist, Karin; Sandberg, Torsten; Connell, Hugh; Svanborg, Catharina

doi:10.1038/ki.1994.74

Cited by 29 publications

(8 citation statements)

References 34 publications

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“…Depending on this result there was significant correlated between study group and mannose binding lectin Polymorphism. The result was agreement with result obtained by 10 who were observed a correlation between the maternal high mannose binding lectin genotype A and premature birth, and it was suggest that during pregnancy mannose binding lectin-associated inflammation caused by higher mannose binding lectin activity may lead to earlier delivery. Moreover, this result finding explain why some peoples are mannose binding lectin deficient in the general population.…”

Section: Resultssupporting

confidence: 92%

Detection of Mannose Binding Lectin (MBL) -54 G/A Polymorphism in Preterm Labor in Hilla Province/Iraq

Abdul-Lateef¹,

Wang²,

Bunyan³

et al. 2018

J Pure Appl Microbiol

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To analyzes the association between Mannose binding lectin MBL gene and preterm labor, DNA was obtained from peripheral blood of 150 aborted women patients diagnosed as preterm labor and 150 healthy individual have no previous preterm history was extracted. Mannose binding lectin gene was genotyped by PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism) method. The data were analyzed by odd ratio (OR) calculation with confidence intervals (CI 95%) and chi square x 2 results were statically analysis. Statistical significant were sent as p value ≤0.05. The allelic frequency between gene and preterm labor group was (94.5) in control compared with (70.7) in patients with significant differences. The homozygous were found to be more than heterozygous (32.3) whereas homozygous AA (43.4) and GG (33.3) with significant differences this work is considered the first study for understanding the correlation between Preterm birth and mannose protein level in Iraq .

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Section: Resultssupporting

confidence: 92%

Detection of Mannose Binding Lectin (MBL) -54 G/A Polymorphism in Preterm Labor in Hilla Province/Iraq

Abdul-Lateef¹,

Wang²,

Bunyan³

et al. 2018

J Pure Appl Microbiol

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“…pregnancy is accompanied by lower levels of IL-6 in serum and urine compared with those in nonpregnant women suffering from pyelonephritis [76]. IL-6 and IL-8 were also detected for up to 6 weeks in the urine of children with acute pyelonephritis [77].…”

Section: Inflammatory Response To Urinary Tract Infectionmentioning

confidence: 96%

Pharmacologic basis for the treatment of pyelonephritis

Beauchamp

Bergeron²

1999

Curr Infect Dis Rep

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Urinary tract infections (UTIs) are among the most common bacterial infections in humans. Even though physicians have been treating UTIs for 60 years, there has been no standardized approach regarding the rational choice of antimicrobial agents and optimal treatment duration for these infections. This review discusses the pharmacologic basis for the treatment of UTIs. Although most antibiotics concentrate well in the urine and can eradicate most of the sensitive uropathogens that cause lower UTI, antibiotics given for the treatment of pyelonephritis must concentrate and kill bacteria embedded within the renal parenchyma. Investigators once believed that antibiotics must concentrate in sufficient amounts in the urine of infected patients to be effective in treating pyelonephritis. In fact, the efficacy of an antibiotic in the treatment of pyelonephritis is proportional to its capacity to converge in high concentration not only in urine but also in the renal parenchyma because serum and urine levels of antibiotics are poor predictors of the intrarenal levels. Other factors should also be taken into consideration in the management of UTIs, such as the time of day antibiotics are given because significant time-dependent differences have been observed in the pharmacokinetics and rate of excretion in urine of several antibiotics. Finally, the authors review the recent development in the inflammatory response in the urinary tract that may explain the clinical features of UTI and may be useful in the diagnosis as well as better management of UTI.

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“…An interesting aspect of pregnancy is a relative status of immunosuppression, presumably due to the presence of the "foreign" genome of the fetus. Petersson et al (101) reported significant decline in the immune response in pregnant subjects to acute pyelonephritis. That is, maternal serum and urine interleukin-6 and specific antibody responses to E. coli were diminished in comparison to the situation in their non-pregnant counterparts at diagnosis.…”

Section: Urinary Tract Infection In Pregnancymentioning

confidence: 99%

Urologic Issues During Pregnancy

Weiss

2004

The Scientific World JOURNAL

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Pregnancy induces a variety of physiologic changes in the urinary tract. When such changes become accentuated the physiologic becomes the pathologic and symptoms arise, at times of significance enough to threaten the well being of mother and/or fetus. This article intends to describe the basis for urinary physiology and its pathologic counterparts during pregnancy. Such a background may then facilitate a rational management protocol for various urologic problems in the gravid state.

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Suppressed antibody and interleukin-6 responses to acute pyelonephritis in pregnancy

Cited by 29 publications

References 34 publications

Detection of Mannose Binding Lectin (MBL) -54 G/A Polymorphism in Preterm Labor in Hilla Province/Iraq

Detection of Mannose Binding Lectin (MBL) -54 G/A Polymorphism in Preterm Labor in Hilla Province/Iraq

Pharmacologic basis for the treatment of pyelonephritis

Urologic Issues During Pregnancy

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