Suppressed networks of inflammatory mediators characterize chronic venous insufficiency

Sachdev, Ulka; Vodovotz, Lena; Bitner, Julie; Barclay, Derek; Zamora, Rubén; Yin, Jinling; Simmons, Richard L.; Vodovotz, Yoram

doi:10.1016/j.jvsv.2017.11.009

Cited by 15 publications

(19 citation statements)

References 36 publications

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“…However, in another study, eotaxin was decreased along with other cytokines in varicose patients. The authors of the study concluded that a generally less varied inflammatory network seems to be present in CVD patients [42]. In our study, apart from VEGF (lower concentrations in the CVD group in the nonstimulated samples), IL-5 was present in significantly lower concentrations in the CVD group in the stimulated samples.…”

Section: Resultssupporting

confidence: 39%

“…It is supposed to have a local impact on tissues in atherosclerosis [41]. In this study, elevated eotaxin concentrations were found in the incompetent vein, while in a study by Sachdev et al, eotaxin was found in lower concentrations in the general circulation of varicose patients [42]. This might indicate its regional role in the pathogenesis of the disease.…”

Section: Resultsmentioning

confidence: 56%

“…The low number of patients is definitely another limitation of this study. The same problem was also met by other authors working on a similar subject [8, 12, 42, 48]. The unanimous results of the studies concerning cytokines in CVD require further investigation with larger groups of patients in order to determine the role of cytokines in CVD and the impact of the oscillatory flow on the functioning of immunological cells.…”

Section: Resultsmentioning

confidence: 77%

“…Other cytokines analyzed in this study were IL-8, IP-10, FGF, GM-CSF, and PDGF-BB and they did not show any significant differences in concentrations between samples. Contradictory results concerning PDGF-BB concentration in incompetent veins have been published [13, 42]. The aforementioned study assessing the effect of CHIVA on cytokine concentrations described a decrease in IP-10 and its increase after surgical flow correction [12].…”

Section: Resultsmentioning

confidence: 99%

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Chemokines and Growth Factors Produced by Lymphocytes in the Incompetent Great Saphenous Vein

Grudzińska

Grzegorczyn

Czuba

2019

Mediators of Inflammation

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The role of cytokines in the pathogenesis of chronic venous disease (CVD) remains obscure. It has been postulated that oscillatory flow present in incompetent veins causes proinflammatory changes. Our earlier study confirmed this hypothesis. This study is aimed at assessing chemokines and growth factors (GFs) released by lymphocytes in patients with great saphenous vein (GSV) incompetence. In 34 patients exhibiting reflux in GSV, blood was derived from the cubital vein and from the incompetent saphenofemoral junction. In 12 healthy controls, blood was derived from the cubital vein. Lymphocyte culture with and without stimulation by phytohemagglutinin (PHA) was performed. Eotaxin, interleukin 8 (IL-8), macrophage inflammatory protein 1 A and 1B (MIP-1A and MIP-1B), interferon gamma-induced protein (IP-10), monocyte chemoattractant protein-1 (MCP-1), interleukin 5 (IL-5), fibroblast growth factor (FGF), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), platelet-derived growth factor-BB (PDGF-BB), and vascular endothelial growth factor (VEGF) were assessed in culture supernatants by a Bio-Plex assay. Higher concentrations of eotaxin and G-CSF were revealed in the incompetent GSV, compared with the concentrations in the patients' upper limbs. The concentrations of MIP-1A and MIP-1B were higher in the CVD group while the concentration of VEGF was lower. In the stimulated cultures, the concentration of G-CSF proved higher in the incompetent GSV, as compared with the patients' upper limbs. Between the groups, the concentration of eotaxin was higher in the CVD group, while the IL-5 and MCP-1 concentrations were lower. IL-8, IP-10, FGF, GM-CSF, and PDGF-BB did not reveal any significant differences in concentrations between the samples. These observations suggest that the concentrations of chemokines and GFs are different in the blood of CVD patients. The oscillatory flow present in incompetent veins may play a role in these changes. However, the role of cytokines in CVD requires further study.

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Section: Resultssupporting

confidence: 39%

Section: Resultsmentioning

confidence: 56%

Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Chemokines and Growth Factors Produced by Lymphocytes in the Incompetent Great Saphenous Vein

Grudzińska

Grzegorczyn

Czuba

2019

Mediators of Inflammation

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“…This is important in itself because a recent study revealed that patients with chronic venous insufficiency present with significantly lower levels of IL-6 and TNF-a, however in the present study, the levels of IL-6 were even lower in DD patients. 49 A recent meta-analysis found higher mean levels of IL-6 and no correlation with TNF-a levels in patients with major depression compared with controls without depression. 50 The small sample size in this study may account for these discrepancies, although adequate data regarding these inflammatory atherosclerosis biomarkers on a large Greek population with DD are missing.…”

Section: Discussionmentioning

confidence: 97%

Carotid Intima-Media Thickness and Circulation Markers of Inflammation in Patients With Depression

Saleptsis

Papaliaga

Σπανός

et al. 2019

Journal of Diagnostic Medical Sonography

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Objective: Growing evidence indicates that depressive disorders (DDs) are an important risk factor for atherosclerosis. The aim of this study was to evaluate the presence of common carotid artery (CCA) intima-media thickness (IMT) and circulation inflammation markers in patients with DD. Methods: A cross-sectional prospective study was undertaken comparing 40 patients with DD to 40 individuals free of depression, matched for age and gender. The Beck Depression Inventory questionnaire, serum total cholesterol, triglycerides, high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor α, P-selectin, and E-selectin levels were measured. The CCA-IMT was assessed with duplex sonography. Results: Patients with DD were more likely to smoke (65% vs 40%; P = .03) and have higher levels of serum total cholesterol (211 mg/dL vs 181 mg/dL; P = .010), triglycerides (138 mg/dL vs 97 mg/dL; P = .005), and P-selectin (0.87 ng/mL vs 0.61 ng/mL; P = .05) and lower levels of interleukin 6 (4.4 ± 2.1 pg/mL vs 10.3 ± 1.1 pg/mL; P = .002). The CCA-IMT was similar in both groups (0.07 ± 0.02 cm vs 0.06 ± 0.01 cm; P = .31). Among those with CCA-IMT in the upper quartile, subjects in the DD group had lower levels of interleukin 6 ( P = .05) and triglycerides ( P = .01) and higher levels of soluble P-selectin ( P = .03). Conclusion: Patients with DD do not present with higher CCA-IMT than a control group, although smoking and a higher level of serum lipids are present. Inflammatory biomarkers seem to be higher in patients with DD.

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Integrating Data-Driven and Mechanistic Models of the Inflammatory Response in Sepsis and Trauma

Vodovotz

2020

Complex Systems and Computational Biology Approaches to Acute Inflammation

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Suppressed networks of inflammatory mediators characterize chronic venous insufficiency

Cited by 15 publications

References 36 publications

Chemokines and Growth Factors Produced by Lymphocytes in the Incompetent Great Saphenous Vein

Chemokines and Growth Factors Produced by Lymphocytes in the Incompetent Great Saphenous Vein

Carotid Intima-Media Thickness and Circulation Markers of Inflammation in Patients With Depression

Integrating Data-Driven and Mechanistic Models of the Inflammatory Response in Sepsis and Trauma

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