2015
DOI: 10.1038/jid.2014.310
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Suppressing AP1 Factor Signaling in the Suprabasal Epidermis Produces a Keratoderma Phenotype

Abstract: Keratodermas comprise a heterogeneous group of highly debilitating and painful disorders characterized by thickening of the skin with marked hyperkeratosis. Some of these diseases are caused by genetic mutation, while other forms are acquired in response to environmental factors. Our understanding of signaling changes that underlie these diseases is limited. In the present study we describe a keratoderma phenotype in mice in response to suprabasal epidermis-specific inhibition of activator protein 1 transcript… Show more

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Cited by 12 publications
(29 citation statements)
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“…Consistent with such a role, we observe a marked shift of loricrin from the cytoplasmic to nuclear compartment in AP1 factor inactivated epidermis of E13.5, E15.5 and E17.5 mice and in cultured cells derived from these mice. This fits with our previous findings showing nuclear loricrin localization in the epidermis of adult TAM67-expressing epidermis (Rorke et al, 2015a; Rorke et al, 2015b). It is interesting that wild-type loricrin moves to the nucleus in the epidermal cells of these AP1 factor perturbed mice (Rorke et al, 2015a; Rorke et al, 2015b).…”
Section: Discussionsupporting
confidence: 93%
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“…Consistent with such a role, we observe a marked shift of loricrin from the cytoplasmic to nuclear compartment in AP1 factor inactivated epidermis of E13.5, E15.5 and E17.5 mice and in cultured cells derived from these mice. This fits with our previous findings showing nuclear loricrin localization in the epidermis of adult TAM67-expressing epidermis (Rorke et al, 2015a; Rorke et al, 2015b). It is interesting that wild-type loricrin moves to the nucleus in the epidermal cells of these AP1 factor perturbed mice (Rorke et al, 2015a; Rorke et al, 2015b).…”
Section: Discussionsupporting
confidence: 93%
“…3D). This is also observed in TAM67-positive adult mouse epidermis (Rorke et al, 2015b; Rorke et al, 2015a). Fig.…”
Section: Resultssupporting
confidence: 55%
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“…9, 10, 27, 55, 56 Inactivation of AP1 factor function in the suprabasal epidermis of TAM67-rTA mice results in a phenotype that includes features of ichthyosis vulgaris (altered epidermal differentiation, reduced filaggrin content) 57 and loricrin keratoderma (pseudoainhum, nuclear loricrin accumulation). 58, 59 A possible model of phenotype development is present in Figure 5e.…”
Section: Discussionmentioning
confidence: 99%