Suppressing effects of glucan on micronuclei induced by cyclophosphamide in mice

Chorvatovičová, Darina; Navarová, Jana

doi:10.1016/0165-7992(92)90088-y

Cited by 24 publications

(12 citation statements)

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“…Thus, even though β-glucan is described as an antioxidant agent, and the mechanism of desmutagenic action is its greatest effectiveness (Patchen et al , 1987; Chorvatovicová, 1991; Slameñová et al , 2003; Oliveira et al , 2006; Oliveira et al , 2007; Magnani et al , 2011; Silva et al , 2012), this could not prevent the damage caused by metabolites of arginine generated in the inflammatory process and the metabolism of chemotherapy. On the other hand, when evaluating the comet assay data, a dose-response curve in chemoprevention of genotoxic damage was seen in the first week of treatment.…”

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of the antimutagenic and antigenotoxic effects of β-glucan extracted from Saccharomyces cerevisiae in acute treatment with multiple doses

et al. 2013

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Ample evidence suggests that cancer is triggered by mutagenic damage and diets or supplements capable of reducing such incidences can be related to the prevention of neoplasy development or to an improvement in life quality of patients who undergo chemotherapy. This research aimed to evaluate the antimutagenic and antigenotoxic activity of β-glucan. We set up 8 experimental groups: control (Group 1), cyclophosphamide (Group 2), Groups 3–5 to assess the effect of β-glucan administration, and Groups 6–8 to evaluate the association between cyclophosphamide and β-glucan. The intraperitonial concentrations of β-glucan used were 100, 150 and 200 mg/kg. Micronucleus and comet assays showed that within the first week of treatment β-glucan presented a damage reduction rate between 100–62.04% and 94.34–59.52% for mutagenic and genotoxic damages, respectively. This activity decreased as the treatment was extended. During the sixth week of treatment antimutagenicity rates were reduced to 59.51–39.83% and antigenotoxicity was not effective. This leads to the conclusion that the efficacy of β-glucan in preventing DNA damage is limited when treatment is extended, and that its use as a chemotherapeutic adjuvant need to be better clarified.

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Section: Discussionmentioning

confidence: 99%

In vivo evaluation of the antimutagenic and antigenotoxic effects of β-glucan extracted from Saccharomyces cerevisiae in acute treatment with multiple doses

et al. 2013

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“…For example, CP, when used as a positive control in mice, is typically administered at concentrations of 12.5-80.0 mg/kg [Chorvatovičová and Navarová, 1992;Hatanaka et al, 1992], which is more than 2 times higher than the dose used in the present study. A typical MTX dose in mice is 20.0 mg/kg [Heddle et al, 1983] compared with our dose of 2.5 mg/kg, while Ara-C is used in mice at doses of 8.0-50.0 mg/kg [Beaula and Subramanyam, 1991;Yamamoto and Kikuchi, 1980] compared with our dose of 3.0 mg/kg.…”

Section: Mn Induction In the Common Marmosetmentioning

confidence: 98%

Micronucleated erythrocyte frequencies in old and new world primates: Measurement of micronucleated erythrocyte frequencies in peripheral blood ofCallithrix jacchus as a model for evaluating genotoxicity in primates

Zúñiga‐González

Gómez‐Meda

Zamora‐Pérez

et al. 2005

Environ. Mol. Mutagen.

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Nonhuman primates are of particular relevance in evaluating the potential toxicity of drugs and environmental agents. We have used previously published information and data from the present study to establish a relationship for New World (NW) and Old World (OW) primates on the basis of the frequency of spontaneous micronucleated erythrocytes (MNEs) observed in peripheral blood. Data on spontaneous MNEs in peripheral blood from 15 species of primates, including humans, indicate that NW primates have significantly (P < 0.01) higher MNE frequencies (group mean, 9.5 +/- 7.3 MNEs/10,000 erythrocytes; range, 0.7-20.5/10,000 erythrocytes) than OW primates (group mean, 1.0 +/- 0.9 MNEs/10,000 erythrocytes; range, 0.0-2.6 MNEs/10,000 erythrocytes). Humans are believed to have developed in the OW, and human MNE frequencies were similar to those described for OW primate species. We selected the common marmoset (Callithrix jacchus), a NW primate, to determine whether therapeutic pediatric doses of Metotrexate (MTX; 2.5 mg/kg), Cyclophosphamide (CP; 5 mg/kg), Cytosine-arabinoside (Ara-C; 3 mg/kg), or 5-Fluorouracil (5-FU; 10 mg/kg), administered daily for two consecutive days, increase the frequency of micronuclei. Micronucleated polychromatic erythrocyte frequencies were increased significantly in groups receiving MTX, CP and Ara-C, while MNE frequencies were increased by the Ara-C treatment. The results of this study indicate that NW primates have higher spontaneous MNE frequencies than OW primates, and because of this, NW primates like the common marmoset, may be suitable for evaluating the genotoxicity of chemical agents.

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“…También se han reportado efectos antimutagénicos (46, 47) quimioprotectores y anticancerígenos de estos compuestos (48)(49)(50)(51). Hay pocos estudios realizados en humanos con el β-glucano PGG.…”

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ß-glucanos: ¿qué tipos existen y cuáles son sus beneficios en la salud?

2014

Rev. chil. nutr.

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INTRODUCCIÓNLa importancia de la fibra dietética como parte de una dieta equilibrada para la salud del ser humano está ampliamente reconocida. Los β-glucanos son un tipo de fibra soluble para los cuales se han propuesto efectos sobre la glicemia, los niveles de insulinemia, el colesterol y la inmunidad. Cereales como la cebada y la avena son reconocidos como buenas fuentes de β-glucanos pero también se pueden encontrar en algas y hongos. Asimismo, sus propiedades parecen estar relacionadas con su peso molecular, estructura química y características reológicas, las cuales pueden variar según el origen del β-glucano (1).Debido a sus efectos potenciales sobre la salud, la industria de alimentos ha utilizado cada vez más los β-glucanos para el desarrollo de alimentos funcionales. Además, sus propiedades reológicas han estimulado su incorporación a distintas matrices alimentarias con el objetivo de mejorar la estabilidad, textura y vida útil del alimento, en remplazo de ciertos aditivos o agentes texturizantes artificiales (2).En los cereales, los β-glucanos se encuentran concentradas en las paredes celulares del endospermo, cuyo desarrollo es dependiente de las condiciones geoclimáticas; estas, por lo tanto, inciden en el contenido de β-glucano del cereal. Este es regulado por la enzima β-glucano endohidrolasa (1→3, 1→4), también conocida como licheninasa o 1→3, 1→4 β-glucanasa, cuya función es promover la degradación de la pared celular

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Suppressing effects of glucan on micronuclei induced by cyclophosphamide in mice

Cited by 24 publications

References 11 publications

In vivo evaluation of the antimutagenic and antigenotoxic effects of β-glucan extracted from Saccharomyces cerevisiae in acute treatment with multiple doses

In vivo evaluation of the antimutagenic and antigenotoxic effects of β-glucan extracted from Saccharomyces cerevisiae in acute treatment with multiple doses

Micronucleated erythrocyte frequencies in old and new world primates: Measurement of micronucleated erythrocyte frequencies in peripheral blood ofCallithrix jacchus as a model for evaluating genotoxicity in primates

ß-glucanos: ¿qué tipos existen y cuáles son sus beneficios en la salud?

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