Suppression and Treatment of Haloperidol Induced Extrapyramidal Side Effects and Anxiety Syndrome by the Coadministeration of Red Rice Bran Oil in Rats

Abstract

Antipsychotic medications may reduce or eliminate symptoms of psychosis. They are not a 'cure' for mental illnesses, but can be an effective part of treating mental disorders. Even though many of the antipsychotics such as haloperidol cannot cure mental illnesses, they are effective in eliminating or reducing psychotic symptoms. However, prolong administration of haloperidol may result in parkinsonian like effects and tardive dyskinesia. The objective of the present research was to determine the effects of long term co-administration of RRBO in diet on haloperidol induced anxiety and EPS. It was hypothesized that co-administration of RRBO by the free radicals scavenging property could alleviate parkinsonian like effects and tardive dyskinesia. The present results showed a reversal of haloperidol induced parkinsonian like effects and tardive dyskinesia in rats cotreated with RRBO.

Oral Administration of Rauwolfia serpentina Plant Extract Mitigated Immobilization Stress-Induced Behavioral and Biochemic and Deficits in Rats

“…Previously, numerous studies have been reported from our laboratory that establish the capability of phytochemicals present in rice bran oil [26], olive oil [27] and the aqueous fruit extract of sea buckthorn [28] to attenuate/or reverse anxiety in rats. Similarly, our laboratory also observed that the oral administration of red rice bran oil averted haloperidol-induced anxiety syndrome in rats [29]. Conversely, oral administration of Nigella sativa (NS) and Olea europaea (OE) oil did not show anxiolytic effects in rats [30].…”

Experimental treatment of antipsychotic-induced movement disorders

“…Recent studies from our laboratory have shown a reversal of haloperidol-induced parkinsonian-like effects and TD in rats cotreated with red rice bran oil (RRBO) 86 as shown in Figure 6 . It is tempting to relate protective and preventive effects of free radical scavenger RRBO with the reversal of haloperidol-induced TD.…”