Suppression byHydrangeae Dulcis Foliumof<scp>D</scp>-Galactosamine-induced Liver Injuryin Vitroandin Vivo

Nakagiri, Ryusuke; Hashizume, Erika; Kayahashi, Shun; Sakata, Yasushi; Kamiya, Toshikazu

doi:10.1271/bbb.67.2641

Cited by 27 publications

(24 citation statements)

References 7 publications

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“…But it also can suffer damage from a variety of hepatotoxins, such as excessive alcohol intake, heavy metals, and organic and inorganic solvents, resulting in excessive generation of free radicals which cause hepatotoxic lesions including acute hepatitis, cirrhosis, portal fibrosis and hepatic carcinoma (Vander et al, 1994;Tolman, Sirrine, 1998;Nakagiri et al, 2003). Rukkumani et al (2004) evaluated the hepatoprotective effect of FA on the toxicity induced by alcohol and poly-unsaturated fatty acids in female Wistar rats by administering (orally) ethanol and sunflower oil at the level of 40 mg FA/kg body weight for 45 days.…”

Section: Hepatoprotective Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

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Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

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Section: Hepatoprotective Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

View full text Add to dashboard Cite

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“…The changes associated with D-GalN induced liver damage are similar to that of acute viral hepatitis [14,15]. Hence, D-GalN mediated hepatotoxicity was chosen as the experimental model.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that D-GalN causes alteration of liver marker enzymes [16]. D-GalN is known to selectively block the transcription and indirectly hepatic protein synthesis and as a consequence of endotoxin toxicity, it causes fulminant hepatitis [15,16]. The toxicity of D-GalN results from inhibition of RNA and protein synthesis in the liver.…”

Section: Discussionmentioning

confidence: 99%

“…The metabolism of D-GalN may deplete several uracil nucleotides including UDPglucose and UDP-galactose. Accumulation of UDP-sugar nucleotide may contribute to the change in the rough endoplasmic reticulum and to the disturbance of protein metabolism [14,15]. Intense D-GalN of the membrane structures is thought to be responsible for loss in the activity of ionic pumps.…”

Section: Discussionmentioning

confidence: 99%

“…Intense D-GalN of the membrane structures is thought to be responsible for loss in the activity of ionic pumps. The impairment in the calcium pumps, with consequent increase in the intracellular calcium is considered to be responsible for cell death [15,16]. D-GalN has been found to induce extensive liver damage within a period of 24 h following intra-peritoneal administration.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Lecithin on d-Galactosamine Induced Hepatotoxicity Through Mitochondrial Pathway Involving Bcl-2 and Bax

et al. 2011

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Twenty four Wistar strain albino rats were used for the investigations. Lecithin 50 and 100 mg/kg b wt was administered for 1 week by oral route. Liver damage was induced by intra peritoneal administration of 400 mg/ kg b wt D-galactosamine on the last day. At the end of the study animals were sacrificed and liver enzyme levels, histopathology, mitochondrial integrity, expression of p53, Bax and Bcl-2 mRNA levels were studied. Increases in the liver enzyme levels by D-GalN were significantly inhibited by pretreatment with lecithin. Histopathological observation further confirmed the hepatoprotective effect of lecithin. In addition, the disruption of mitochondrial membrane, up regulation of Bax and down regulation of Bcl-2 mRNA levels in the liver of D-GalN intoxicated rats were effectively prevented by pretreatment with lecithin. The results of the present study validate our conviction that D-GalN causes hepatic damage via mitochondrial pathway involving Bax and Bcl-2.

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Dr. Duke’s Phytochemical and Ethnobotanical Databases, a Cornerstone in the Validation of Ethnoveterinary Medicinal Plants, as Demonstrated by Data on Pets in British Columbia

Lans¹,

Asseldonk

2020

Medicinal and Aromatic Plants of the World

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Suppression byHydrangeae Dulcis FoliumofD-Galactosamine-induced Liver Injuryin Vitroandin Vivo

Cited by 27 publications

References 7 publications

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Effect of Lecithin on d-Galactosamine Induced Hepatotoxicity Through Mitochondrial Pathway Involving Bcl-2 and Bax

Dr. Duke’s Phytochemical and Ethnobotanical Databases, a Cornerstone in the Validation of Ethnoveterinary Medicinal Plants, as Demonstrated by Data on Pets in British Columbia

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