Suppression of Aldosterone Synthesis and Secretion by Channel Antagonists

Ikeda, Keiichi; Isaka, Tsuyoshi; Fujioka, Kouki; Manome, Yoshinobu; Tojo, Katsuyoshi

doi:10.1155/2012/519467

Cited by 10 publications

(10 citation statements)

References 54 publications

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“…This result may be because in our study, cases were young, healthy adults, while in other studies, cases were hypertensive individuals. This study differs from the study in Japan [11], which showed a significantly different in the level of plasma aldosterone in the hypertensive groups. Additionally, the highest level of aldosterone was found in individuals with the CC genotype, compared with those with the TC and TT genotypes, and individuals with the TC + CC genotype had higher aldosterone levels than those with the TT genotype.…”

Section: Discussioncontrasting

confidence: 99%

“…The TC and CC genotypes were higher in cases than in the controls, and they were risk factors for hypertension. This result was consistent with studies carried out in Japanese [11] and Chinese populations [13]. The TC + CC genotypes were more common in hypertensive patients compared with normotensive patients.…”

Section: Discussionsupporting

confidence: 92%

“…Hypertension subjects with TT and TC genotypes have a higher aldosterone/renin ratio than those with the TT genotype 10 , which contributes to the pathogenesis of hypertension. Aldosterone levels are involved in the development of hypertension because high aldosterone levels result in excessive sodium retention 11 . The -344 T/C aldosterone synthase polymorphism increases the expression of aldosterone synthase, which leads to increased aldosterone levels in the blood.…”

Section: Introductionmentioning

confidence: 99%

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Aldosterone levels and the -344t/C aldosterone synthase in individuals with a family history of hypertension

Setyawati

Sunarti²,

Hastuti

2016

Bangladesh J Med Sci

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Abstract:Background: Genetic factors play an important role in the determination of hypertensive disease in a family. The -344T/C the aldosterone synthase gene has been reported in various populations closely related to hypertension. The aim of this study was to determine the presence of the -344T/C polymorphism of the aldosterone synthase gene and the levels of plasma aldosterone in individuals with and without a family history of hypertension. Methods: This study was a case control design, with healthy individuals with a family history of hypertension as cases (n-42) and those without a family history of hypertension as controls (n=41). The subjects' plasma aldosterone levels were analysed by enzyme-link immunosorbent assay (ELISA) and the gene polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The data were analysed by an independent sample T-test and Chi square test, and the significance level was set at P<0.05. Result: The frequency of the TT + TC genotype was higher in cases, and this increase was significant different compared to the controls (P<0.046). The frequency of the TT + TC genotype was 2.56 higher in cases than controls. The frequency of the C allele in cases was also significantly different compared to the controls (P = 0.039) and 2.29 more frequent in cases than the controls (P = 0.039). The plasma aldosterone level was 42.35 pg/dL in cases and 34.9 pg/dL in controls (P = 0.616). Plasma aldosterone level in cases with the CC, TC and TT genotypes were 48.29, 40.8 and 35.2 pg/dL, respectively (P = 0.774). Our study concludes that individuals with a family history of hypertension are at a higher risk of developing hypertension. Follow-up studies are required to determine the incidence of hypertension in a person with a family history of hypertension and who is a carrier of genetic risk factors.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Aldosterone levels and the -344t/C aldosterone synthase in individuals with a family history of hypertension

Setyawati

Sunarti²,

Hastuti

2016

Bangladesh J Med Sci

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“…Several dihydropyrine calcium channel antagonists weakly antagonize the mineralocorticoid receptor or inhibit key enzymes of aldosterone biosynthesis (most notably CYP1B2). 73,74 Nifedipine, nitrendipine and felodipine are the available molecules with the greatest antialdosterone potency. Nifedipine has been tested as a monotherapy in 10 PA patients, and was shown to have a significant effect on BP, serum potassium and aldosterone concentrations at four weeks.…”

Section: Drug-based Treatment For Pamentioning

confidence: 99%

Outcomes of Drug-Based and Surgical Treatments for Primary Aldosteronism

Steichen

Lorthioir

Zinzindohoué

et al. 2015

Advances in Chronic Kidney Disease

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Treatments for primary aldosteronism (PA) aim to correct or prevent the deleterious consequences of hyperaldosteronism: hypertension, hypokalemia and direct target organ damage. Patients with unilateral PA considered fit for surgery can undergo laparoscopic adrenalectomy, which significantly decreases blood pressure and medications in most cases, and cures hypertension in about 40%. Mineralocorticoid receptor antagonists (MRA) are used to treat patients with bilateral PA and those with unilateral PA if surgery is not possible or not desired. Spironolactone is more potent than eplerenone, but high doses are poorly tolerated in men. MRA can be replaced or complemented with epithelial sodium channel blockers, such as amiloride. Thiazide diuretics and calcium channel blockers are used when the first-line drugs are insufficient to control blood pressure. Dietary sodium restriction should be implemented in all cases, because the deleterious consequences of hyperaldosteronism are dependent on salt loading. Several studies comparing the results of surgery and MRA have reported no differences in terms of blood pressure, serum potassium concentration or cardiovascular and renal outcomes, although the benefits of treatment tend to be observed sooner with surgery.PA patients display relative glomerular hyperfiltration, which is reversed by specific treatment, revealing chronic kidney disease in 30% of patients. However, further kidney damage is prevented by the treatment of PA. Clinical summary-The goals of treatment are the normalization of serum potassium concentration, blood pressure control and prevention of the direct effects of excess aldosterone on target organs. 3-The non-surgical treatment of PA is based on mineralocorticoid receptor antagonists and dietary sodium restriction.-Epithelial sodium channel blockers are used when mineralocorticoid receptor antagonists are not well tolerated; thiazide diuretics and calcium channel blockers are used when blood pressure control is insufficient with the first-line treatment.-Laparoscopic adrenalectomy is safe and decreases BP and medication requirements in patients with unilateral PA; drug-based treatments are appropriate in cases in which surgery is inappropriate or not desired.

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“…1 In past years, interactions between cations and secretagogeous, in the process of hormone release have been studied by examining the effects of various organic calcium antagonists upon isolated secretory tissues. 2 The effects of these agents are overcome by increased concentration of extracellular calcium. Because of high activity and apparent selection of these agents, their activity in other systems can be viewed as evidence that basically slow calcium channels are operative in variety of secretory processes.…”

Section: Introductionmentioning

confidence: 99%

Effect of calcium channel blockers on the serum levels of thyroid hormone

Kaur

Mehta

Ambwani

et al. 2013

Int J Basic Clin Pharmacol

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Background: The effect of the calcium channel blockers on the cardiovascular system is implemented judiciously in different conditions related to cardiovascular system such as angina pectoris, hypertension, and in cardiac arrhythmias but the aspect that deals with the impact of blockade of calcium channels in other systems like endocrine system remains eclipsed. These effects generally go unnoticed and the present study was formulated to elucidate the serum T3, T4, TSH levels after administration of calcium channel blockers and to observe the resultant side effect on the endocrine glands, if any by this commonly used group of drugs. Methods: The study was conducted on male albino rabbits, they were divided in three groups of ten each and each group received one of the calcium channel blockers- Verapamil, Diltiazem and Nifedipine for three months. At the end of each month the serum T3, T4, TSH levels were evaluated by chemiluminisence. Results: It was found that on continuous daily administration of calcium channel blockers there was a gradual fall in levels of T3 and T4 with rise in TSH levels in comparison to the control value taken before initiating the drug therapy. Conclusion: These findings could have potential clinical implications and this study proposes the importance of blood thyroid hormone level follow up in the long-term calcium channel blocker therapy. [Int J Basic Clin Pharmacol 2013; 2(4.000): 476-479

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Suppression of Aldosterone Synthesis and Secretion by Channel Antagonists

Cited by 10 publications

References 54 publications

Aldosterone levels and the -344t/C aldosterone synthase in individuals with a family history of hypertension

Aldosterone levels and the -344t/C aldosterone synthase in individuals with a family history of hypertension

Outcomes of Drug-Based and Surgical Treatments for Primary Aldosteronism

Effect of calcium channel blockers on the serum levels of thyroid hormone

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