Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways

Chen, Chien Ho; Sheu, Ming Thau; Chen, Tzeng-Fu; Wang, Ying Ching; Hou, Wen Chi; Liu, Der Zen; Chung, Tsao-Chuen; Liang, Yu Chih

doi:10.1016/j.bcp.2006.07.001

Cited by 141 publications

(111 citation statements)

References 25 publications

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“…2. Recently, Chen et al (2006) have shown that when LPS-activated macrophages are Science Publications AJPT incubated with 90% esterified pectin they inhibit the activation and binding of Nf-kB and AP-1 transcriptional factors to the respective promoter nucleotide sequences and down-regulates the mRNA and protein expression of iNOS and COX2. The activation of transcriptional factors Nf-kB and AP-1 are known to be involved in the pathogenesis of numerous cancers (Fujioka et al, 2004).…”

Section: Pectin Mcp and Their Molecular Interaction In Cancermentioning

confidence: 99%

Plant Pectin: A Potential Source for Cancer Suppression

Niture¹

2013

American Journal of Pharmacology and Toxicology

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Pectin is a branched polysaccharide present widely in a variety of fruits. It has been of high interest to cancer biologists due to its involvement in metal/carcinogen detoxification and its anti-carcinogenic properties. In particular, Citrus Pectin (CP) and Modified Citrus Pectin (MCP) have been shown to have a significant inhibitory role in cancer cell metastasis, invasion, angiogenesis and survival. The interactions and inactivation of oncogenes by CP and MCP in prostate, breast, liver, lung, melanoma and multiple myeloma cancers suggest that CP and MCP could play an important role in cancer chemotherapy and chemoprevention. In this review, we focus on the biological function of pectin with respect to its properties, sources, structure and its potential role in carcinogen detoxification and cancer suppression.

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Section: Pectin Mcp and Their Molecular Interaction In Cancermentioning

confidence: 99%

Plant Pectin: A Potential Source for Cancer Suppression

Niture¹

2013

American Journal of Pharmacology and Toxicology

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“…In addition, MCP can inhibit morphogenesis of endothelial cells and angiogenesis by blocking galectin-3, thus intercepting cancer cells to absorb nutrition from vessels and cancer progression [24,25] . However, there is no evidence that MCP attacks cancer cells directly or indirectly with or without toxicity and side effects [26] .…”

Section: Groups N Expression Of Galectin-3 H P (-) (+) (++) (+++)mentioning

confidence: 99%

Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model

Liu

Huang²,

Yang³

et al. 2008

WJG

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and MCP treatment groups was significantly higher than that in the negative control group. However, there was no significant difference between them. Except for the negative control group, the expression of galectin-3 in liver metastases of the other 4 groups showed no significant difference. CONCLUSION: Expression of galectin-3 increases significantly in liver metastasis of colon cancer, which can be effectively inhibited by MCP.

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“…Commercial pectins are almost exclusively derived from citrus peel or apple pomace, both of which are by-products from juice manufacturing units. Pectin is thought to consist mainly of Dgalacturonic acid (GalA) units, joined in chains by means of á (14) glycosidic linkage [83]. Pectin is used for making mucoadhesive patches in combination with carbopol and chitosan.…”

Section: Pectinmentioning

confidence: 99%