Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin

Zhao, Jiong; Sun, Xuebing; Ye, Fei; Tian, Wei-Xi

doi:10.1007/s11010-010-0707-z

Cited by 99 publications

(70 citation statements)

References 24 publications

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“…Furthermore, curcumin treatment along with high-fructose diet down-regulated the hepatic expression of ACC and FAS. Curcumin competitively binds to malonyl/acetyl transferase domain and covalently modifies FAS thereby decreasing TAG synthesis (Zhao et al 2011). Another study reported that curcumin inhibits hepatic lipogenesis through down-regulation of SREBP1c expression (Shao et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats

Maithilikarpagaselvi

Sridhar

Swaminathan

et al. 2016

Pharmaceutical Biology

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Context: Curcumin, an active principal of Curcuma longa Linn. (Zingiberaceae), has potent antioxidant and anti-inflammatory properties. Objectives: This study investigated the effects of curcumin on hyperlipidemia and hepatic steatosis in high-fructose-fed Wistar rats. Materials and methods: Forty male Wistar rats were divided into four groups with 10 rats in each. Two groups were fed with standard rodent diet and the other two with 60% high-fructose diet for 10 weeks. Curcumin (200 mg/kg body weight) was administered along with the diets simultaneously to each of the aforementioned diet groups. After 10 weeks of experiment, blood samples were collected from tail vein. Liver, adipose and epididymal tissues were collected after sacrifice of the animals and stored for further analyses. Results: Administration of curcumin reduced body weight (280.6 ± 7.4 g), liver weight (2.5 ± 0.2 g/100 g BW), adipose weight (1.4 ± 0.3 g/100 g BW), plasma levels of TAG (86.1 ± 13.5 mg/dL), VLDL-C (17.2 ± 2.7 mg/dL), lipid ratios and increased HDL-C (28.4 ± 4.5 mg/dL) in fructose-fed rats. Curcumin supplementation significantly lowered TAG content and decreased the protein expression of LXR-a (43%) and SREBP1c (59%) in the liver. Furthermore, curcumin suppressed the expression of lipogenic enzymes, ACLY (95%), ACC (50%) and FAS (77%) in rats fed with high-fructose diet. No significant change was found in the expression of PPAR-a. Discussion and conclusion: Curcumin prevented the high-fructose induced hyperlipidemia and hepatic steatosis.

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Section: Discussionmentioning

confidence: 99%

Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats

Maithilikarpagaselvi

Sridhar

Swaminathan

et al. 2016

Pharmaceutical Biology

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“…HDL-cholesterol is good for health, since it facilitates mobilization of triglycerides and cholesterol from the plasma to the liver [55]. Curcumin decreases the expression of FAS, a key enzyme in the de novo long-chain FA synthesis pathway [56]. Moreover, curcumin enhanced FA β-oxidation in adipocytes with a concomitant increase in the expression of CPT-1, a key enzyme in transferring acyl-CoA into mitochondria for β-oxidation [57].…”

Section: Discussionmentioning

confidence: 99%

Antihypercholesterolemic Effects of Mushroom, Chrysin, Curcumin and Omega-3 in Experimental Hypercholesterolemic Rats

Ismail¹,

Soliman²,

Nassan³

et al. 2015

JFNR

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Hypercholesterolemia and hypertriglyceridemia are major risk factors that accelerate the incidence of atherosclerosis and coronary artery diseases. Therefore, the present study was conducted to evaluate the hypolipidemic effect of widely known traditional medicinal herbs and omega-3 FA in experimental hypercholesterolemia induced by Triton WR-1339. Experimental hypercholesterolemic rats were administered mushroom, chrysin, curcumin and omega-3 for 2 weeks. Hypercholesterolemic rats showed an increase in serum levels of lipid profiles and hepatic enzymes. Hypercholesterolemic rats showed an increase in malondialdehyde (MDA) levels and a decrease in both serum levels and mRNA expression of catalase, superoxide dismutase (SOD) and glutathione reducatse. Moreover, hypercholesterolemic rats showed hepatic down regulation in the expression of genes related to fatty acids oxidation such as acyl CoA oxidase (ACO) and synthetase (ACS), together with carnityl palmityl transferase-1 (CPT-1) and peroxisome proliferator activator receptor-α (PPAR-α). Administration of mushroom, chrysin, curcumin and omega-3 to hypercholesterolemic rats for 2 weeks up-regulated significantly the down regulated genes. In contrast, expression of genes related to fatty acids biosynthesis and cholesterol metabolism were increased in hypercholesterolemic rats compared to control group. Herbal medications and omega-3 administration down regulated genes of fatty acids biosynthesis and cholesterol metabolism to normal expression. At cellular levels, hyperlipidemia induced fatty droplets accumulation, necrosis and presence of apoptotic hepatocytes together with leukocytic infiltration in necrotic area that are ameliorated and normalized after administration of herbs and omega-3. In conclusion, the current findings indicated that flavonoids (mushroom, chrysin, curcumin) and omega-3 possess antihypercholesterolemic effects at biochemical, molecular and histopathological levels and are useful in treatment of hypercholesterolemia with lower side effects compared with synthetic hypolipidemic drugs.

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“…The addition of curcumin, the major polyphenol found in turmeric, to rodent models of obesity has been shown to reduce body weight gain and ameliorate the development of diabetes (123,124) . This is thought to be due to its ability to suppress adipocyte differentiation and indeed this has been found in studies using the murine 3T3-L1 cell line, with a concomitant downregulation of PPARg (125,126) ; however, in another study utilising 3T3-L1 cells, these transcriptional markers were not affected (124) . A recent comprehensive investigation into the ligand activity of curcumin found it to have no binding activity at the PPARg ligand-binding site and subsequently no effect on adipocyte differentiation (127) .…”

Section: Adipocyte Hypertrophymentioning

confidence: 90%

Pathogenic obesity and nutraceuticals

2011

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Over a decade of intense research in the field of obesity has led to the knowledge that chronic, excessive adipose tissue expansion leads to an increase in the risk for CVD, type 2 diabetes mellitus and cancer. This is primarily thought to stem from the low-grade, systemic inflammatory response syndrome that characterises adipose tissue in obesity, and this itself is thought to arise from the complex interplay of factors including metabolic endotoxaemia, increased plasma NEFA, hypertrophic adipocytes and localised hypoxia. Plasma concentrations of vitamins and antioxidants are lower in obese individuals than in the non-obese, which is hypothesised to negatively affect the development of inflammation and disease in obesity. This paper provides a review of the current literature investigating the potential of nutraceuticals to ameliorate the development of oxidative stress and inflammation in obesity, thereby limiting the onset of obesity complications. Research has found nutraceuticals able to positively modulate the activity of adipocyte cell lines and further positive effects have been found in other aspects of pathogenic obesity. While their ability to affect weight loss is still controversial, it is clear that they have a great potential to reverse the development of overweight and obesity-related comorbidities; this, however, still requires much research especially that utilising well-structured randomised controlled trials.

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Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin

Cited by 99 publications

References 24 publications

Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats

Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats

Antihypercholesterolemic Effects of Mushroom, Chrysin, Curcumin and Omega-3 in Experimental Hypercholesterolemic Rats

Pathogenic obesity and nutraceuticals

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