Suppression of lactation with stilbestrol

Morton, Daniel G.; Miller, John S.

doi:10.1016/0002-9378(51)91034-4

Cited by 11 publications

(1 citation statement)

References 8 publications

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“…Diethylstilbestrol (DES) was synthetized by Dodds in 1938, and has been widely used as therapeutic estrogen to prevent miscarriages, inhibit lactation, and to treat many hormonal disorders [ 1 ]. The urogenital effects (e.g., female genital abnormalities, vaginal cancer, and male urogenital disorders) of DES exposure during fetal life have been well documented for several decades.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family

Soyer‐Gobillard

Gaspari

Paris

et al. 2021

IJERPH

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Background: Psychiatric disorders in children exposed in utero to diethylstilbestrol (DES) are still debated. We report here the impact of DES prescribed to suppress lactation on the children born after such treatment and their progeny, focusing particularly on psychiatric disorders. Case presentation: We report here an informative family in which one or more psychiatric problems (e.g., bipolarity, suicide attempts and suicide, eating disorders) were detected in all children of second-generation (DES-exposed children; n = 9), but for II-2 who died at the age of 26 years due to rupture of a congenital brain aneurysm, and were associated with non-psychiatric disorders (particularly, endometriosis and hypospadias). In the third generation, 10 out of 19 DES-exposed grandchildren had psychiatric disorders (autism spectrum disorder, bipolar disorder, dyspraxia and learning disabilities, mood and behavioral disorders, and eating disorders), often associated with comorbidities. In the fourth generation (7 DES-exposed great-grandchildren, aged between 0 and 18 years), one child had dyspraxia and autism spectrum disorder. The first daughter of the second generation (not exposed to DES) and her children and grandchildren did not have any psychiatric symptoms or comorbidities. Conclusions: To our knowledge, the high prevalence of psychiatric disorders of various severities in two, and likely three generations, including DES-free pregnancies and DES-exposed pregnancies from the same family, has never been reported. This work strengthens the hypothesis that in utero exposure to DES contributes to the pathogenesis of psychiatric disorders. It also highlights a multigenerational, and possibly transgenerational, effect of DES in neurodevelopment and psychiatric disorders.

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Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family

Soyer‐Gobillard

Gaspari

Paris

et al. 2021

IJERPH

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Suppression of Lactation

Bare¹

1960

JAMA

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An evaluation of the use of stilboestrol and antibiotics in the early management of acute puerperal breast abscess

Benson

Goodman

1970

Journal of British Surgery

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One hundred and seventy‐five cases of acute breast abscess treated surgically have been described. The supposed rationale for the early use of stilboestrol and antibiotics in this condition has been reviewed. Neither stilboestrol nor antibiotics confers any benefit with regard to rate of healing or recurrent abscess formation after incision. Whilst full evaluation of these drugs in breast abscess awaits a prospective trial, it is suggested that, in the case of stilboestrol, there are sufficient potential dangers to make its routine prescription undesirable, if not indefensible. In the case of antibiotics since no apparent benefit is conferred it might reasonably be concluded that administration is merely wasteful.

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Suppression of lactation with stilbestrol

Cited by 11 publications

References 8 publications

Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family

Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family

Suppression of Lactation

An evaluation of the use of stilboestrol and antibiotics in the early management of acute puerperal breast abscess

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