Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage

Dubois, Violaine; Chatagnon, Jonathan; Thiriard, Anaïs; Roy, Hélène Bauderlique‐Le; Debrie, Anne-Sophie; Coutte, Loïc; Locht, Camille

doi:10.1038/s41541-020-00270-8

Cited by 41 publications

(38 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(43)(44)(45) Bordetella Pertussis CD69+CD4+T RM cells T RM cells produced IL-17 and IFN-g, thereby recruiting neutrophils and preventing their colonization in the nose. (46)(47)(48)(49) Influenza Viruses…”

Section: Respiratory Syncytial Virusmentioning

confidence: 99%

The Roles of Tissue-Resident Memory T Cells in Lung Diseases

Yuan

Jiao

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

The unique environment of the lungs is protected by complex immune interactions. Human lung tissue-resident memory T cells (TRM) have been shown to position at the pathogen entry points and play an essential role in fighting against viral and bacterial pathogens at the frontline through direct mechanisms and also by orchestrating the adaptive immune system through crosstalk. Recent evidence suggests that TRM cells also play a vital part in slowing down carcinogenesis and preventing the spread of solid tumors. Less beneficially, lung TRM cells can promote pathologic inflammation, causing chronic airway inflammatory changes such as asthma and fibrosis. TRM cells from infiltrating recipient T cells may also mediate allograft immunopathology, hence lung damage in patients after lung transplantations. Several therapeutic strategies targeting TRM cells have been developed. This review will summarize recent advances in understanding the establishment and maintenance of TRM cells in the lung, describe their roles in different lung diseases, and discuss how the TRM cells may guide future immunotherapies targeting infectious diseases, cancers and pathologic immune responses.

show abstract

Section: Respiratory Syncytial Virusmentioning

confidence: 99%

The Roles of Tissue-Resident Memory T Cells in Lung Diseases

Yuan

Jiao

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Most importantly, however, while protective against pertussis disease, pertussis vaccination has at best limited effects on the prevention of colonization by and transmission of B. pertussis [26]. Furthermore, experimental studies in baboons and mice suggest that acellular pertussis vaccination may result in prolonged nasal carriage of B. pertussis [26][27][28][29].…”

Section: Effect Of Pertussis Vaccination and The Recent Resurgence Ofmentioning

confidence: 99%

“…The recently developed baboon model recapitulates the nearly full spectrum of human pertussis, including paroxysmal cough [39] and airborne transmission of B. pertussis from animal to animal [49]. aP vaccination of baboons protected these animals from pertussis disease, but did not prevent infection and transmission [26], and in fact, similar to mice [27][28][29], prolonged nasal carriage of B. pertussis. In contrast, wP vaccination did not prolong nasal carriage in baboons, which cleared the infection faster than non-vaccinated baboons, although much less efficiently than convalescent baboons [26].…”

Section: The Importance Of Animal Modelsmentioning

confidence: 99%

The Path to New Pediatric Vaccines against Pertussis

Locht

2021

Vaccines

Self Cite

View full text Add to dashboard Cite

Whooping cough, or pertussis, mostly caused by Bordetella pertussis, is a respiratory disease that affects all age groups, but severe and fatal pertussis occurs almost exclusively in young children. The widespread use of whole-cell and, more recently, of acellular vaccines has substantially reduced the disease incidence. However, it has not been eliminated in any part of the world and has made a worrisome rebound in several areas. Cocoon and maternal immunization have been implemented in several countries but have their intrinsic limitations. To effectively control pertussis, novel vaccines are needed that protect against disease and prevent B. pertussis infection and transmission, which is not the case for current vaccines. Several approaches are contemplated, including alternative administration routes, such as nasal immunization, improvement of acellular vaccines by adding more antigens and T-cell-promoting adjuvants, and the development of novel vaccines, such as outer membrane vesicles and live attenuated vaccines. Among them, only a live attenuated vaccine has so far been assessed for safety and immunogenicity in preclinical models other than mice and is in clinical development. Before any of these vaccines can be used in neonates, extensive safety and immunogenicity assessment in pre-clinical neonatal models and in carefully designed clinical trials is necessary. The aim of this review is to discuss the current pertussis problem, implemented strategies to resolve it, the value of animal models and novel vaccine approaches.

show abstract

“…While aPV have shown their protective efficacy against pertussis disease, several studies have suggested that they do not prevent B. pertussis infection and transmission [ 71 , 72 ]. In fact, murine studies suggest that aPV immunization may even prolong nasal carriage by inhibiting the recruitment of IL-17-producing resident memory T cells and neutrophils to the nasal tissue [ 73 ]. In contrast, live attenuated pertussis vaccines in which PT has been genetically inactivated have been shown in non-human primates to protect against both pertussis disease and nasal colonization [ 74 , 75 ].…”

Section: From Pt/pa To Apvmentioning

confidence: 99%

The History of Pertussis Toxin

Locht

Antoine

2021

Toxins

Self Cite

View full text Add to dashboard Cite

Besides the typical whooping cough syndrome, infection with Bordetella pertussis or immunization with whole-cell vaccines can result in a wide variety of physiological manifestations, including leukocytosis, hyper-insulinemia, and histamine sensitization, as well as protection against disease. Initially believed to be associated with different molecular entities, decades of research have provided the demonstration that these activities are all due to a single molecule today referred to as pertussis toxin. The three-dimensional structure and molecular mechanisms of pertussis toxin action, as well as its role in protective immunity have been uncovered in the last 50 years. In this article, we review the history of pertussis toxin, including the paradigm shift that occurred in the 1980s which established the pertussis toxin as a single molecule. We describe the role molecular biology played in the understanding of pertussis toxin action, its role as a molecular tool in cell biology and as a protective antigen in acellular pertussis vaccines and possibly new-generation vaccines, as well as potential therapeutical applications.

show abstract

Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage

Cited by 41 publications

References 47 publications

The Roles of Tissue-Resident Memory T Cells in Lung Diseases

The Roles of Tissue-Resident Memory T Cells in Lung Diseases

The Path to New Pediatric Vaccines against Pertussis

The History of Pertussis Toxin

Contact Info

Product

Resources

About