Suppression of Murine IgE Responses with Amino Acid Polymer/Allergen Conjugates

Dc, Henderson; Aw, Wheeler; Dm, Moran

doi:10.1159/000234188

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…Administration of antigen by the i.n. route has been shown to induce IgE responses in a variety of systems (Holt et al, 1981a;McCaskill et al, 1982McCaskill et al, , 1984Enander et al, 1985;Henderson et al, 1985Henderson et al, , 1987Takafuji et al, 1987Takafuji et al, , 1989Tamura et al, 1994a). The magnitude of the IgE response varies from system to system and is sometimes dependent on adjuvant administration.…”

Section: Discussionmentioning

confidence: 99%

Specific Antibody Responses to Subtilisin Carlsberg (Alcalase) in Mice: Development of an Intranasal Exposure Model

et al. 1996

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Section: Discussionmentioning

confidence: 99%

Specific Antibody Responses to Subtilisin Carlsberg (Alcalase) in Mice: Development of an Intranasal Exposure Model

et al. 1996

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“…[92] The reduced IgE response was transient [93] and was attributed partly to a short-lived antigen-specific T cell suppression. [94] It was further demonstrated that intranasal application of the conjugate can reduce the serum IgE antibody response that was brought about through exposure to the grass pollen extract, [95] providing a method to treat allergy. Kimura et al…”

Section: Immunogenicitymentioning

confidence: 99%

Polypeptoid polymers: Synthesis, characterization, and properties

et al. 2017

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Polypeptoids, a class of peptidomimetic polymers, have emerged at the forefront of macromolecular and supramolecular science and engineering as the technological relevance of these polymers continues to be demonstrated. The chemical and structural diversity of polypeptoids have enabled access to and adjustment of a variety of physicochemical and biological properties (eg, solubility, charge characteristics, chain conformation, HLB, thermal processability, degradability, cytotoxicity and immunogenicity). These attributes have made this synthetic polymer platform a potential candidate for various biomedical and biotechnological applications. This review will provide an overview of recent development in synthetic methods to access polypeptoid polymers with well-defined structures and highlight some of the fundamental physicochemical and biological properties of polypeptoids that are pertinent to the future development of functional materials based on polypeptoids. | I N TR ODU C TI ONPolypeptoids composed of N-substituted polyglycine backbones are structural mimics of polypeptides ( Figure 1). Because of N-substitution, polypeptoids lack stereogenic centers and hydrogen bonding interactions along the main chains, in sharp contrast to polypeptides.As a result, the global conformations of polypeptoids are strongly dependent on the N-substituent structures, giving rise to random coils or well-defined secondary structures [eg, polyproline I (PPI) helix [1][2][3][4][5][6] and R-sheets] [7][8][9][10][11][12] that are reminiscent of those of polypeptides. The polypeptoid backbone containing tertiary amide linkages is highly polar and hydrophilic. The physicochemical properties of polypeptoids can be tailored by the N-substituent structures, enabling control over the hydrophilicity and lipophilicity balance (HLB), charge characteristics, [13,14] backbone conformation, [1][2][3][4][5][6][7][8][9][10][11][12] solubility, [15][16][17][18][19][20] thermal and crystallization properties of the polypeptoids. [21][22][23][24] Without extensive hydrogen bonding, polypeptoids are thermally processable similar to conventional thermoplastics, [20][21][22][23][24] whereas polypeptides undergo thermal degradation before they can be melt-processed due to the extensive hydrogen bonding interactions. While polypeptoids exhibited enhanced proteolytic stability relative to peptides, [25,26] they can be oxidatively degraded under conditions that mimic tissue inflammation, [27] suggesting their potential in vivo uses as biodegradable materials.Recent advances in the controlled polymerization methods have enabled access to a suite of structurally well-defined polypeptoids with various N-substituent structures and molecular architectures, setting the stage for the future development of polypeptoid materials for various targeted applications. Several review articles on the synthesis, properties, and application of polypeptoids for biomedical or nonbiomedical uses have been published in recent years. [28][29][30][31][32] As a result, this...

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“…First, hints toward the nonimmunogenicity of poly(sarcosine) (PSR) were given by Blout et al as early as 1959 . Later, in a series of papers which appear to have been largely forgotten, Moran and co-workers investigated PSR conjugates to allergens such as grass pollen extract. − It was found that PSR-conjugation was suitable to suppress an immune response to an antigen after antigen conjugation.…”

Section: Applications Of (Poly)peptoidsmentioning

confidence: 99%

“…In the last communication of this series, the level of serum IgE was also followed in mice intranasally exposed to grass pollen . The mice were also treated with a conjugate of PSR to grass pollen.…”

Section: Applications Of (Poly)peptoidsmentioning

confidence: 99%