Suppression of Natural Killer Cell Activity in Humans by Radiation from Solarium Lamps Depleted of UVB

Hersey, Peter; MacDonald, Malcolm; Henderson, Christine.; Schibeci, Stephen D.; D'alessandro, G.; Pryor, Maureen.; Wilkinson, F. J.

doi:10.1111/1523-1747.ep12456090

Cited by 52 publications

(20 citation statements)

References 19 publications

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“…A parallel in vivo observation has been reported by Hersey and coworkers, who found that repeated in vivo l exposures of normal subjects to UV-A induced a reduced natural killer cell activity up to 14 days after exposure.8 9 Interestingly, this inhibitory pattern was most pronounced in normal donors, whereas only natural killer cells from some patients with SLE reacted as controls. In contrast, five of 12 patients with SLE increased their RNK value when cells were exposed to UV-A irradiation.…”

Section: Discussionsupporting

confidence: 70%

“…7 In solar simulator studies, with a dominance of long wavelength ultraviolet light (UV-A), increased suppressor T cell activity reducing natural killer cell function has been reported in vivo in normal subjects. 8 9 It has also been reported that the in vitro exposure of normal natural killer cells to UV-B radiation inhibits their function by a direct non-lethal effect, and that this inhibition occurs selectively at the postbinding stage of target lysis. '°In this work the in vitro effects of irradiation with UV-A light of natural killer cells from patients with SLE have been studied.…”

mentioning

confidence: 99%

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Effects of ultraviolet irradiation on natural killer cell function in systemic lupus erythematosus.

Nived

Johansson

Sturfelt

1992

Annals of the Rheumatic Diseases

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Section: Discussionsupporting

confidence: 70%

mentioning

confidence: 99%

Effects of ultraviolet irradiation on natural killer cell function in systemic lupus erythematosus.

Nived

Johansson

Sturfelt

1992

Annals of the Rheumatic Diseases

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“…Secretion of IL-12p40 homodimers may also help to explain why rather large amounts of rIL-12 are needed to overcome UVinduced immune suppression in vivo (15). Furthermore, because IL-12 is a critical factor in the activation of NK cells, the UVinduced suppression of IL-12p70 secretion and the enhancement of IL-12p40 homodimer secretion may provide a mechanism by which UV exposure down-regulates NK cell activity (36,37), potentially contributing to skin cancer progression. DC appear to have two different developmental stages that are defined by their function.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Ultraviolet Radiation Causes Dendritic Cells/Macrophages to Secrete Immune-Suppressive IL-12p40 Homodimers

Schmitt

Ullrich

2000

The Journal of Immunology

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UV-induced immune suppression is a risk factor for sunlight-induced skin cancer. Exposure to UV radiation has been shown to suppress the rejection of highly antigenic UV-induced skin cancers, suppresses delayed and contact hypersensitivity, and depress the ability of dendritic cells to present Ag to T cells. One consequence of UV exposure is altered activation of T cell subsets. APCs from UV-irradiated mice fail to present Ag to Th1 T cells; however, Ag presentation to Th2 T cells is normal. While this has been known for some time, the mechanism behind the preferential suppression of Th1 cell activation has yet to be explained. We tested the hypothesis that this selective impairment of APC function results from altered cytokine production. We found that dendritic cells/macrophages (DC/Mφ) from UV-irradiated mice failed to secrete biologically active IL-12 following in vitro stimulation with LPS. Instead, DC/Mφ isolated from the lymphoid organs of UV-irradiated mice secreted IL-12p40 homodimer, a natural antagonist of biologically active IL-12. Furthermore, when culture supernatants from UV-derived DC/Mφ were added to IL-12-activated T cells, IFN-γ secretion was totally suppressed, indicating that the IL-12p40 homodimer found in the supernatant fluid was biologically active. We suggest that by suppressing DC/Mφ IL-12p70 secretion while promoting IL-12p40 homodimer secretion, UV exposure preferentially suppress the activation of Th1 cells, thereby suppressing Th-1 cell-driven inflammatory immune reactions.

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“…Several previous studies have reported that exposure of humans to indoor sources of UVR as well as sunlight can produce evidence of immunosuppression (32)(33)(34)(35). The specific findings in these studies are in broad agreement with the findings of the present study; although there are some differences in the particulars.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Suntan Parlor Exposure on Delayed and Contact Hypersensitivity

Whitmore¹,

Morison²

2007

Photochemistry and Photobiology

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Cutaneous and systemic immune function are believed to play an important role in cutaneous carcinogenesis. We therefore sought to determine whether the suntan parlor radiation sources commonly used in the United States cause measurable qualitative suppression of immune function and quantitative alterations in circulating T cell subpopulations. Subjects (n = 22) were recruited and randomly assigned to receive suntan parlor exposures (10 full‐body UV exposures over a 2 week period, shielding only the right flexural arm) or no exposure. Baseline circulating T lymphocyte subpopulations (T helper lymphocyte, CD4; T suppressor/cytotoxic lymphocyte, CD8) were measured. Two weeks later (upon completion of UV exposures for those in this group), circulating T cell subpopulations were measured and dinitrochlorobenzene (DNCB) sensitization (in the UV group, on the UV‐exposed buttock) was performed. Subsequent DNCB elicitation was performed in a bilateral fashion (in the UV group, on the right UV‐shielded and the left UV‐exposed upper arm). We found that subjects in the UV group demonstrated localized suppression of contact hypersensitivity sensitization and elicitation and also an increase in circulating CD8 cells when compared to the control group (P≤ 0.05). We conclude that suntan parlor exposures, as typically received in this country, suppress contact hypersensitivity and increase the circulating T suppressor/cytotoxic cell number quantity.

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Suppression of Natural Killer Cell Activity in Humans by Radiation from Solarium Lamps Depleted of UVB

Cited by 52 publications

References 19 publications

Effects of ultraviolet irradiation on natural killer cell function in systemic lupus erythematosus.

Effects of ultraviolet irradiation on natural killer cell function in systemic lupus erythematosus.

Exposure to Ultraviolet Radiation Causes Dendritic Cells/Macrophages to Secrete Immune-Suppressive IL-12p40 Homodimers

The Effect of Suntan Parlor Exposure on Delayed and Contact Hypersensitivity

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