Suppression of reflex saliva from rat parotid gland following intracerebroventricular injection of hypertonic NaCl and sucrose

Ito, Kayoko; Morikawa, Masao; Inenaga, Kiyotoshi

doi:10.1016/s0003-9969(01)00084-x

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…injection of drugs was implanted in the lateral cerebral ventricle of each rat under sodium pentobarbital anesthesia (60 mg/kg of body weight, i.p. ), as described in our previous study (16). A stainless steel guide cannula was implanted into the lateral cerebral ventricle 0.8 mm caudal to the bregma, 1.4 mm to the right lateral side to midline, and 2.5 mm below the dura matter.…”

Section: Cannulation Proceduresmentioning

confidence: 99%

Central nicotinic stimulation reduces vascular conductance in the gingiva in anesthetized rats

Nakamura

Ono²,

Honda³

et al. 2004

J of Periodontal Research

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Section: Cannulation Proceduresmentioning

confidence: 99%

Central nicotinic stimulation reduces vascular conductance in the gingiva in anesthetized rats

Nakamura

Ono²,

Honda³

et al. 2004

J of Periodontal Research

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“…We have reported that intracerebroventricular hypertonic stimulation decreased parotid salivary flow rate and induced thirst in conscious rats, implying that central thirst stimulation decreases salivary secretion through a specific neural pathway (Ito et al, 2002). Since intraperitoneal injection of pilocarpine induced thirst in the present study, the central action might suppress the increased salivary secretion by the peripheral action on the salivary gland.…”

Section: Pilocarpine-induced Parotid Salivary Secretionmentioning

confidence: 44%

“…A 24-gauge stainless-steel guide cannula for intracerebroventricular injection of drugs was implanted into each rat under sodium pentobarbital anesthesia (60 mg/kg, intraperitoneally injected), as described in our previous studies (Ito et al, 2001(Ito et al, , 2002Nakamura et al, 2005). The cannulas were implanted into the lateral cerebral ventricles 0.8 mm caudal to the bregma, 1.4 mm to the right lateral to the midline, and 2.5 mm below the dura mater.…”

Section: Brain Surgerymentioning

confidence: 99%

Pilocarpine-induced Salivation and Thirst in Conscious Rats

et al. 2006

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The muscarinic receptor agonist pilocarpine is widely used as a sialogogue. It has been well-established that it also induces water intake in animals. However, the mechanisms underlying the relationships between these events are unknown. To address this problem, we examined water intake and parotid salivary secretion in conscious rats. Intraperitoneally injected pilocarpine increased both water intake and salivary secretion. Intracerebroventricularly injected pilocarpine also induced water intake, but not salivary secretion. Intracerebroventricularly applied atropine, a muscarinic receptor antagonist, suppressed the water intake produced by pilocarpine applied intraperitoneally and intracerebroventricularly. However, it did not affect the salivary secretion induced by pilocarpine applied peripherally. We conclude that peripherally applied pilocarpine affects the parotid glands and the thirst center in the central nervous system, while it may induce salivary secretion mainly via peripheral responses, but water intake mainly via the central nervous system.

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