Suppression of resistance to aminolevulinic acid-based photodynamic therapy in esophageal cell lines by administration of iron chelators in collagen type I matrices

A review on ferroptosis and photodynamic therapy synergism: Enhancing anticancer treatment

“…PDT can induce different cell death modalities in cancer cells, including apoptosis, accidental necrosis, necroptosis and pyroptosis [ 26 , 27 ]. Recent studies suggest that PDT can also induce ferroptosis in cancer cells [ [28] , [29] , [30] , [31] ]. Cell death in GL261 cells induced by photosens-PDT was found to be significantly blocked by ferrostatin-1 (Fer-1) and Deferoxamine (DFO), ferroptosis inhibitors, which implied that photosens-PDT induced ferroptosis in GL261 cells [ 24 ].…”

“…Aminolevulinic acid (ALA) is a widely used photosensitizer, and ferroptosis is also a potential cell death modality induced by ALA-PDT. Features of several cell death modalities were observed after ALA-PDT in esophageal Kyse 450 carcinoma cells by fluorescence-based live cell imaging, including apoptosis, necrosis and ferroptosis [ 30 ].…”