Suppressive activities of mangiferin on human epithelial ovarian cancer

Zeng, Zheng; Lin, Caiji; Wang, Siwen; Wang, Pengfei; Xu, Wenwen; Ma, Wenqing; Wang, Jiali; Xiang, Qing; Liu, Yiting; Yang, Jiaming; Ye, Fan; Xie, Kaihong; Xu, Jian; Luo, Yao; Liu, Shulin; Liu, Huidi

doi:10.1016/j.phymed.2020.153267

Cited by 35 publications

(24 citation statements)

References 30 publications

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“…Mangiferin has been shown to restore the learning and memory impairments and to decrease hippocampal injury in a mouse model [109]. A recent study demonstrated that mangiferin potently inhibits the progression of human epithelial ovarian cancer [14]. A human study revealed that supplementation with mangiferin combined with luteolin enhances the exercise spring performance and brain oxygenation during sprint exercise in physically active men [110].…”

Section: Discussionmentioning

confidence: 99%

“…Unripe mango tastes sour because of the presence of different acids, such as citric acid, malic acid, oxalic acid, succinic, and other organic acids, whereas the sweet taste of the ripened fruit is due to the blending of reducing sugar and the main acid source, malic acid [11]. High concentrations of β-carotene and other phytochemicals in mangoes can prevent leukemia and progression of prostate, breast, and colon cancers [12][13][14][15][16]. Mangoes can be differentiated in to three parts: pulp (mesocarp), peel (epicarp), and seed kernel (endocarp), as presented in Figure 2.…”

Section: Introductionmentioning

confidence: 99%

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Nutritional Composition and Bioactive Compounds in Three Different Parts of Mango Fruit

Reddy

Wee

et al. 2021

IJERPH

196

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Mango (Mangifera indica L.), known as the king of fruits, has an attractive taste and fragrance and high nutritional value. Mango is commercially important in India, where ~55% of the global crop is produced. The fruit has three main parts: pulp, peel, and kernel. The pulp is the most-consumed part, while the peel and kernel are usually discarded. Mango pulp is a source of a variety of reducing sugars, amino acids, aromatic compounds, and functional compounds, such as pectin, vitamins, anthocyanins, and polyphenols. Mango processing generates peels and kernels as bio-wastes, though they also have nutraceutical significance. Functional compounds in the peel, including protocatechuic acids, mangiferin and β-carotene are known for their antimicrobial, anti-diabetic, anti-inflammatory, and anti-carcinogenic properties. The mango kernel has higher antioxidant and polyphenolic contents than the pulp and peel and is used for oil extraction; it’s possible usage in combination with corn and wheat flour in preparing nutraceuticals is being increasingly emphasized. This review aims to provide nutraceutical and pharmacological information on all three parts of mango to help understand the defense mechanisms of its functional constituents, and the appropriate use of mangoes to enhance our nutrition and health.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nutritional Composition and Bioactive Compounds in Three Different Parts of Mango Fruit

Reddy

Wee

et al. 2021

IJERPH

196

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“…38 Natural xanthone mangiferin from traditional Chinese medicine exhibited suppressed activities on human epithelial OC. 39 A number of xanthones from Garcinia nujiangensis showed potent cytotoxicity against selective cancer cells, [21][22][23]40 among them, Nujiangexathone A inhibited cervical cancer via hnRNPK, 41 and induced caspase-dependent apoptosis via ROS/JNK pathway, 42 in addition, it had anti-inflammatory and anti-allergic effects. 43 2 featured with a xanthone skeleton showed inhibitory effects on the proliferation and induced apoptosis on human OC.…”

Section: Molecular Docking Analysismentioning

confidence: 99%

<p>Anti-Tumor Xanthones from <em>Garcinia nujiangensis</em> Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells</p>

Tang¹,

Lu²,

Xia³

2020

DDDT

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Background: Ovarian cancer (OC) is a serious public health concern in the world. It is important to develop novel drugs to inhibit OC. Purpose: This study investigated the isolation, elucidation, efficiency, molecular docking, and pharmaceutical mechanisms of xanthones isolated from Garcinia nujiangensis. Methods: Xanthones were isolated, and purified by different chromatography, including silica gel, reversed-phase silica gel (ODS-C 18), and semipreparative HPLC, then identified by analysis of their spectral data. Three xanthones were estimated for their efficiency on the human OC cells HEY and ES-2. 2 was found to be the most potent cytotoxic xanthones of those tested. Further, its mechanisms of action were explored by molecular docking, cell apoptosis, and Western blotting analysis. Results: Bioassay-guided fractionation of the fruits of Garcinia nujiangensis led to the separation of a new xanthone named nujiangexanthone G (1) and two known xanthones. Among these, isojacareubin (2) exhibited the most potent cytotoxic compound against the HEY and ES-2 cell lines. The analysis of Western blot suggested that 2 inhibited OC via regulating the PARP, PI3K/ AKT/mTOR, and ERK/MAPK signal pathways in the HEY cell lines. Conclusion: In conclusion, isojacareubin (2) might be a potential drug for the treatment of OC.

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“…In addition, compound target libraries were also supplemented the reported targets of GSZD in previous literature. [11][12][13][14][15][16][17][18][19] To Establish RA Targets Library As a common data platform, the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/ geo) allows open access to gene expression data of arrays, chips and microarrays. We focused only on the comparison of gene expression data sets between synovial tissue samples from patients with RA and normal synovial tissue.…”

Section: Data Collection and Data Preprocessingmentioning

confidence: 99%

“…At the same time, existing studies have shown that GSZD can play a role in RA treatment by regulating the expression of JAK2, CASPA3, BAX, BCL2 and other genes or proteins. 2,[16][17][18] Therefore, these targets are also taken into account in the construction of RA target library.…”

Section: Target Prediction Of Gszd Against Ramentioning

confidence: 99%

Inducing Apoptosis and Suppressing Inflammatory Reactions in Synovial Fibroblasts are Two Important Ways for Guizhi-Shaoyao-Zhimu Decoction Against Rheumatoid Arthritis

Zhang

Duan

et al. 2021

JIR

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Background and Objectives Guizhi-Shaoyao-Zhimu decoction (GSZD) is often applied to control rheumatoid arthritis (RA), gout, osteoarthritis, etc. In this study, bioinformatic analysis and experimental verification were used to uncover the integral mechanism profile of GSZD against RA. Materials and Methods The chemical compositions of GSZD were identified by UPLC-QTOF-MS/MS. MH7A cell model was established to screen active compounds in GSZD, and potential targets of these compounds were predicted through online database retrieval. The differential expression genes (DEGs) in synovial tissue of RA patients and normal controls were retrieved from the GEO database. DEGs and the predicated compounds targets were overlapped, and the overlapped genes were subsequently enriched by GO and KEGG analysis. The pathways with significant enrichments were further experimentally verified. Results A total of 19 constituents were identified from GSZD, and 11 compounds showed obviously antiproliferative effects on MH7A cells with IC 50 < 100 μg/mL. Bioinformatic analysis indicated that IL-1β, IL-6, MAPK8 , JAK2 , CXCL8 , and CASP3 were the main targets of GSZD, and the integral pharmacological mechanisms profile of GSZD might be related to anti-inflammation and proapoptosis. GSZD can promote the loss of mitochondrial membrane potential (MOMP) and induce apoptosis in MH7A cells. Furthermore, in vitro experiments showed GSZD can not only downregulate mRNA expressions of IL-1β ( p <0.05), IL-6 ( p <0.05), MMPs ( p <0.05) and CCL5 ( p <0.05) but also inhibit the nuclear transcription of NF-κB. GSZD also reduced the expressions of Bcl-2 ( p <0.05), JAK2 ( p <0.05), STAT-3 ( p <0.05), whereas increase Bax ( p <0.05), Caspase-3 ( p <0.05) and caspase-9 ( p <0.05). Conclusion Collectively, inducing synovial fibroblast apoptosis and inhibiting inflammatory response are two important ways for GSZD to RA, and our study proved bioinformatic analysis combined with experimental verification is a feasible method to explore the drug targets and mechanism of actions of TCMs.

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Suppressive activities of mangiferin on human epithelial ovarian cancer

Cited by 35 publications

References 30 publications

Nutritional Composition and Bioactive Compounds in Three Different Parts of Mango Fruit

Nutritional Composition and Bioactive Compounds in Three Different Parts of Mango Fruit

<p>Anti-Tumor Xanthones from <em>Garcinia nujiangensis</em> Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells</p>

Inducing Apoptosis and Suppressing Inflammatory Reactions in Synovial Fibroblasts are Two Important Ways for Guizhi-Shaoyao-Zhimu Decoction Against Rheumatoid Arthritis

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