Suppressive Activity of the Fruit of Momordica charantia with Exercise on Blood Glucose in Type 2 Diabetic Mice

Miura, Toshihiro; Itoh, Yasushi; Iwamoto, Naoki; Kato, Motoshi; Ishida, Tatsuro

doi:10.1248/bpb.27.248

Cited by 44 publications

(30 citation statements)

References 11 publications

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“…For the same reason, fresh bitter melon might have more potent activity to ameliorate postprandial hyperglycemia than the bitter melon extracts used in our study. However, at least in part, our data may explain why bitter melon ameliorated serum insulin and blood glucose levels in dietinduced obese rats and in type 2 diabetic mice, but did not in normal mice as previously reported (14)(15)(16).…”

Section: Discussionsupporting

confidence: 70%

“…In addition, protein extract from bitter melon has been shown to have insulinomimetic and insulin secretagogue effects ( 13 ). However, bitter melon reduces serum insulin and blood glucose levels in diet-induced obese rats and in type 2 diabetic mice, but does not affect normal mice (14)(15)(16). This effect of bitter melon conflicts with its insulinomimetic and insulin secretagogue effects.…”

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confidence: 99%

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Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats

Uebanso

Arai

Taketani

et al. 2007

J Nutr Sci Vitaminol

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Summary Momordica charantia (bitter melon) is commonly known as vegetable insulin, but the mechanisms underlying its hypoglycemic effect remain unclear. To address this issue, the effects of bitter melon extracts on postprandial glycemic responses have been investigated in rats. An aqueous extract (AE), methanol fraction (MF) and methanol insoluble fraction (MIF) were prepared from bitter melon. An oral sucrose tolerance test revealed that administration of AE, MF or MIF each significantly suppressed plasma glucose levels at 30 min as compared with the control. In addition, the plasma insulin level at 30 min was also significantly lower after MF administration than in the control in the oral sucrose tolerance test. By contrast, these effects of bitter melon extracts were not observed in the oral glucose tolerance test. In terms of mechanism, bitter melon extracts dose-dependently inhibited the sucrase activity of intestinal mucosa with IC 50 values of 8.3, 3.7 and 12.0 mg/ mL for AE, MF and MIF, respectively. The fraction with a molecular weight of less than 1,300 (LT 1,300) obtained from MF inhibited the sucrase activity most strongly in an uncompetitive manner with an IC 50 value of 2.6 mg/mL. Taken together, these results demonstrated that bitter melon suppressed postprandial hyperglycemia by inhibition of ␣ -glucosidase activity and that the most beneficial component is present in the LT 1,300 fraction obtained from MF.

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Section: Discussionsupporting

confidence: 70%

mentioning

confidence: 99%

Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats

Uebanso

Arai

Taketani

et al. 2007

J Nutr Sci Vitaminol

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“…Este efecto ha sido demostrado además en diferentes modelos animales (Miura et al 2004;Zheng et al 2005;Sathishsekar & Subramanian, 2005).…”

Section: Discussionunclassified

“…La planta es muy común en las cercas de patios, fincas y potreros de toda la isla (Roig & Mesa, 1974). En la farmacología y actividad biológica de M. charantia, varios autores han estudiado el efecto hipoglicémico de la pulpa del fruto, semillas y planta entera, reportándose actividad de la planta para disminuir los niveles de glucosa (Miura et al 2004).…”

Section: Introductionunclassified

“…Por otro lado, M. charantia también reduce los niveles de insulina y glucosa sérica en ratas con obesidad inducida y ratones con diabetes tipo 2, aunque no posee efectos en ratones normales (Miura et al 2004;Miura et al 2001;Chen et al 2003). Estos datos sugieren que esta planta contiene varios componentes que disminuyen la hiperglicemia y la incidencia de diabetes mellitus.…”

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Evaluación preclínica y estudio de estabilidad de extractos a partir del follaje de Momordica charantia Lin

Lagarto

Sánchez

Piloto

et al. 2014

Rev. bras. plantas med.

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Evaluación preclínica y estudio de estabilidad de extractos a partir del follaje de RESUMEN:El objetivo del presente trabajo fue la evaluación preclínica y el estudio de estabilidad de extractos a partir del follaje de Momordica charantia Lin. Se obtuvieron extractos acuoso e hidroalcohólico para los cuales se establecieron las especificaciones de calidad mediante la evaluación de tres lotes y se estudió su estabilidad por el método de vida de estante durante 12 meses. A los extractos se le evaluó el potencial genotóxico mediante ensayos de micronúcleos en médula ósea de ratón y aberraciones cromosómicas en linfocitos de sangre periférica. La actividad hipoglicemiante oral fue evaluada en animales con hiperglicemia temporal inducida por carga de glucosa. Como resultados se establecieron las especificaciones de calidad de los extractos acuoso e hidroalcohólico, los mismos mostraron estabilidad por 6 meses para el extracto acuoso y 12 meses para el extracto hidroalcohólico. No mostraron efecto genotóxico en los ensayos evaluados y mostraron efecto hipoglicemiante oral a la dosis de 450 mg/kg. Palabras clave:Momordica charantia Lin, extractos, estabilidad, genotoxicidad, hipoglicemiante. ABSTRACT: Obtaining and characterizing the Momordica charantia Linn leaf extracts.The objective of this investigation was the preclinical evaluation and the stability study of the Momordica charantia Linn hydroalcoholic and aqueous leaf extracts. The hydroalcoholic and aqueous extracts were obtained and the quality specifications were determined by evaluating three lots. The stability of the extracts was evaluated for 12 months. The genotoxic potential of the extracts was evaluated by mouse bone marrow micronucleus test and chromosome aberration test. The hypoglycemic effect was determined by oral glucose tolerance test. As results, the quality specifications were established and the aqueous extract was stable for 6 months and the hydroalcoholic extract for 12 months. A genotoxic effect was not observed in both extracts and the hypoglycemic effect was observed at the oral dose of 450 mg/kg of body weight.

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Momordica charantia for type 2 diabetes mellitus

Ooi¹,

Yassin²,

Hamid³

2009

Cochrane Database of Systematic Reviews

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Momordica charantia (bitter gourd) is not only a nutritious vegetable but it is also used in traditional medical practices to treat type 2 diabetes mellitus. Experimental studies with animals and humans suggested that the vegetable has a possible role in glycaemic control. To assess the effects of mormodica charantia for type 2 diabetes mellitus. Several electronic databases were searched, among these were The Cochrane Library (Issue 1, 2012), MEDLINE, EMBASE, CINAHL, SIGLE and LILACS (all up to February 2012), combined with handsearches. No language restriction was used. We included randomised controlled trials (RCTs) that compared momordica charantia with placebo or a control intervention, with or without pharmacological or non-pharmacological interventions. Two authors independently extracted data. Risk of bias of the trials was evaluated using the parameters of randomisation, allocation concealment, blinding, completeness of outcome data, selective reporting and other potential sources of bias. A meta-analysis was not performed given the quality of data and the variability of preparations of momordica charantia used in the interventions (no similar preparation was tested twice). Four randomised controlled trials with up to three months duration and investigating 479 participants met the inclusion criteria. Risk of bias of these trials (only two studies were published as a full peer-reviewed publication) was generally high. Two RCTs compared the effects of preparations from different parts of the momordica charantia plant with placebo on glycaemic control in type 2 diabetes mellitus. There was no statistically significant difference in the glycaemic control with momordica charantia preparations compared to placebo. When momordica charantia was compared to metformin or glibenclamide, there was also no significant change in reliable parameters of glycaemic control. No serious adverse effects were reported in any trial. No trial investigated death from any cause, morbidity, health-related quality of life or costs. There is insufficient evidence on the effects of momordica charantia for type 2 diabetes mellitus. Further studies are therefore required to address the issues of standardization and the quality control of preparations. For medical nutritional therapy, further observational trials evaluating the effects of momordica charantia are needed before RCTs are established to guide any recommendations in clinical practice.

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Suppressive Activity of the Fruit of Momordica charantia with Exercise on Blood Glucose in Type 2 Diabetic Mice

Cited by 44 publications

References 11 publications

Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats

Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats

Evaluación preclínica y estudio de estabilidad de extractos a partir del follaje de Momordica charantia Lin

Momordica charantia for type 2 diabetes mellitus

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