Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure

Çört, Ayşegül; Ozturk, Nihal; Akpınar, Deniz; Ünal, Mustafa; Yucel, Gultekin; Çiftçioğlu, Akif; Yargiçoğlu, Pi̇raye; Aslan, Mutay

doi:10.1016/j.yrtph.2010.05.001

Cited by 47 publications

(29 citation statements)

References 59 publications

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“…Nakajima et al, 46 found that astaxanthin had neuroprotective effects against retinal ganglion cell damage. Recently, Cort et al, 47 showed that astaxanthin significantly decreased the percent of apoptotic cells on the retina in rats with elevated intraocular pressure .This study confirmed the role of oxidative injury in elevated intraocular pressure and highlighted the protective effect of astaxanthin in ocular hypertension 47 .…”

Section: Astaxanthin As Powerful Antioxidantsupporting

confidence: 56%

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2012

IJPSR

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Astaxanthin, a member of the carotenoid family, is a dark-red pigment which is the main carotenoid found in the marine world of algae and aquatic animals. Astaxanthin, is present in many types of seafood, including salmon, trout, red sea bream, shrimp and lobster, as well as in birds such as flamingo and quail. Synthetic Astaxanthin dominates the world market but recent interest in natural sources of the pigment has increased substantially.

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Section: Astaxanthin As Powerful Antioxidantsupporting

confidence: 56%

Untitled

2012

IJPSR

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“…Nakajima et al [116] found that astaxanthin had neuroprotective effects against retinal ganglion cell damage. Recently, Cort et al [117] showed that astaxanthin significantly decreased the percent of apoptotic cells on the retina in rats with elevated intraocular pressure. This study confirmed the role of oxidative injury in elevated intraocular pressure and highlighted the protective effect of astaxanthin in ocular hypertension [117].…”

Section: Ocular Protective Effectmentioning

confidence: 99%

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

555

309

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The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight. Astaxanthin has been attributed with extraordinary potential for protecting the organism against a wide range of diseases, and has considerable potential and promising applications in human health. Numerous studies have shown that astaxanthin has potential health-promoting effects in the prevention and treatment of various diseases, such as cancers, chronic inflammatory diseases, metabolic syndrome, diabetes, diabetic nephropathy, cardiovascular diseases, gastrointestinal diseases, liver diseases, neurodegenerative diseases, eye diseases, skin diseases, exercise-induced fatigue, male infertility, and HgCl₂-induced acute renal failure. In this article, the currently available scientific literature regarding the most significant activities of astaxanthin is reviewed.

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“…81 Conversely, a recent study showed that treatment with astaxanthin, a naturally occurring carotenoid pigment and a powerful biological antioxidant, reduced oxidant-induced protein oxidation, lipid peroxidation, and apoptotic cell death in experimental rat models of elevated IOP. 82 Polyphenolic flavonoids ( present in tea, coffee, wine, dark chocolate, and Ginkgo bilboa), alpha lipoic acid, coenzyme Q10, and melatonin are natural substances with antioxidant activity in glaucomatous neurodegeneration. 83 Melatonin is not only an antioxidant but also acts by decreasing the IOP.…”

Section: Potential Applications Of Free Radical Scavengers In Glaucomamentioning

confidence: 99%

Oxidative stress and potential applications of free radical scavengers in glaucoma

2013

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Glaucoma is the leading cause of irreversible blindness in industrialized countries and comprises a group of diseases characterized by progressive optic nerve degeneration. Glaucoma is commonly associated with elevated intraocular pressure due to impaired outflow of aqueous humor resulting from abnormalities within the drainage system of the anterior chamber angle (open-angle glaucoma) or impaired access of aqueous humor to the drainage system (angle-closure glaucoma). Oxidative injury and altered antioxidant defense mechanisms in glaucoma appear to play a role in the pathophysiology of glaucomatous neurodegeneration that is characterized by death of retinal ganglion cells. Oxidative protein modifications occurring in glaucoma serve as immunostimulatory signals and alter neurosupportive and immunoregulatory functions of glial cells. Initiation of the apoptotic cascade observed in glaucomatous retinopathy can involve oxidant mechanisms and different agents have been shown to be neuroprotective. This review focuses on the molecular mechanisms of oxidant injury and summarizes studies that have investigated novel free radical scavengers in the treatment of glaucomatous neurodegeneration.

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Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure

Cited by 47 publications

References 59 publications

Untitled

Untitled

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Oxidative stress and potential applications of free radical scavengers in glaucoma

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