Suppressive Effect of Imipramine on Vincristine-Induced Mechanical Allodynia in Mice

Saika, Fumihiro; Kiguchi, Norikazu; Kobayashi, Yuka; Fukazawa, Yohji; Maeda, Takehiko; Kishioka, Shiroh

doi:10.1248/bpb.32.1231

Cited by 14 publications

(13 citation statements)

References 35 publications

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“…As demonstrated earlier by previous studies, in the present study, vincristine injected rats exhibited CIPN which was evident from significant decrease in nociceptive threshold in thermal, mechanical hyperalgesic, allodynic, and formalin test models [13,34]. Vincristine injected rats also displayed decreased motor nerve conduction velocity, functional (sciatic functional index) loss, oxidative stress and increased TNF-a in sciatic nerve in the present study.…”

Section: Discussionsupporting

confidence: 89%

Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

Greeshma¹,

Prasanth²,

Bhaskar³

2015

Chemico-Biological Interactions

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Section: Discussionsupporting

confidence: 89%

Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

Greeshma¹,

Prasanth²,

Bhaskar³

2015

Chemico-Biological Interactions

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“…As demonstrated earlier, vincristine-injected mice exhibited CIPN which was evident from significant decrease in nociceptive threshold in hyperalgesic, allodynic, and formalin test models (Hansen et al, 2011;Saika et al, 2009). Vincristine-injected mice also displayed functional (SFI) loss and oxidative stress in sciatic nerve in the present study.…”

Section: Discussionsupporting

confidence: 55%

Effect of curcumin in mice model of vincristine-induced neuropathy

Babu¹,

Prasanth²,

Bhaskar³

2014

Pharmaceutical Biology

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Context: Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and antioxidant activity. Objective: The present study evaluates the effect of curcumin in vincristine-induced neuropathy in a mice model. Materials and methods: Vincristine sulfate (0.1 mg/kg, i.p. for 10 consecutive days) was administered to mice to induce neuropathy. Pain behavior was assessed at different days, i.e., 0, 7, 10, and 14 d. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days. Results: Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p50.001) and allodynia (p50.001); mechanical hyperalgesia (p50.001); functional loss (p50.001); and in the delayed phase of formalin test (p50.001). Curcumin at 30 and 60 mg/kg exhibited significant changes (p50.001) in antioxidant levels and in total calcium levels in vincristine-injected mice. Conclusion: Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristineinduced neuropathy which may be due to its multiple actions including antinociceptive, calcium inhibitory, and antioxidant effect.

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“…Vincristine, one of the most commonly used chemotherapeutic agents, has been reported to cause severe neurotoxicity in the clinic. In this regard, vincristine has been a useful tool for inducing peripheral neuropathy in rats (Aley, Reichling, & Levine, ; Boyle, Wheeler, & Shenfield, ; Higuera & Luo, ; Wala, Crooks, McIntosh, & Holtman, ) and later in mice (Nakamura, Shimizu, Nishijima, Ueno, & Arakawa, ; Saika et al, ; Uceyler et al, ). Similar to previous studies (Authier et al, ), rats treated with vincristine (75 μg kg −1 day −1 ) lost body weight on day 5 and continued to lose weight throughout the treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, in other rat studies with vincristine administered at 50–150 μg kg −1 , no myelin or axonal damage was observed in the peripheral nerve inside the paw skin (Authier, Gillet, Fialip, Eschalier, & Coudore, ) or in the saphenous nerve (Tanner, Levine, & Topp, ; Topp, Tanner, & Levine, ). Although no pharmacokinetic analyses were performed in this study, based on the literature (Authier et al, ; Saika et al, ), vincristine at the doses we used should attain adequate exposure in both species. Taken together, we highly believe the animals in the current study underwent peripheral neuropathy.…”

Section: Discussionmentioning

confidence: 99%

A novel endpoint for the assessment of chemotherapy‐induced peripheral neuropathy in rodents: biomechanical properties of peripheral nerve

Liu

Berryman

Zakur

et al. 2017

J of Applied Toxicology

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Chemotherapy-induced peripheral neuropathy (CiPN) is a frequent adverse effect in patients and a leading safety consideration in oncology drug development. Although behavioral assessment and microscopic examination of the nerves and dorsal root ganglia can be incorporated into toxicity studies to assess CiPN risk, more sensitive and less labor-intensive endpoints are often lacking. In this study, rats and mice administered vincristine (75 μg kg day , i.p., for 10 days in rats and 100 μg kg day , i.p., for 11 days in mice, respectively) were employed as the CiPN models. Behavioral changes were assessed during the dosing phase. At necropsy, the sural or sciatic nerve was harvested from the rats and mice, respectively, and assessed for mechanical and histopathological endpoints. It was found that the maximal load and the load/extension ratio were significantly decreased in the nerves collected from the animals dosed with vincristine compared with the vehicle-treated animals (P < 0.05). Additionally, the gait analysis revealed that the paw print areas were significantly increased in mice (P < 0.01), but not in rats following vincristine administration. Light microscopic histopathology of the nerves and dorsal root ganglia were unaffected by vincristine administration. We concluded that ex vivo mechanical properties of the nerves is a sensitive endpoint, providing a new method to predict CiPN in rodent. Gait analysis may also be a useful tool in these pre-clinical animal models.

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Suppressive Effect of Imipramine on Vincristine-Induced Mechanical Allodynia in Mice

Cited by 14 publications

References 35 publications

Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

Effect of curcumin in mice model of vincristine-induced neuropathy

A novel endpoint for the assessment of chemotherapy‐induced peripheral neuropathy in rodents: biomechanical properties of peripheral nerve

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