Suppressive Effects of Eugenol and Ginger Oil on Arthritic Rats

Sharma, J. N.; Srivastava, Krishna C.; Gan, E. K.

doi:10.1159/000139248

Cited by 118 publications

(68 citation statements)

References 10 publications

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“…Many studies were carried out on the pungent constituents of fresh and dried ginger rhizomes. Among the pharmacological effects demonstrated are antiplatelets, antioxidant, anti-tumor, anti-rhino viral, anti-hepatotoxicity, anti-arthritic effect and anti-inflammatory [3][4][5]. The 6-Gingerol is an important active principle of plant which has been used as a marker compound for quality control and standardization of the plant and its formulations.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Method for Densitometric Analysis of 6-Gingerol in Herbal extracts and Polyherbal Formulation

Jain¹,

Tatiya²,

Bagul³

2011

J Anal Bioanal Techniques

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ValidationLinearity: The linear regression data for the calibration curves showed good linear relationship over the concentration range 150-900ng/spot. Linear regression equation was found to be Y = 4.103x+398.6 (r 2 = 0.9981). The result is expressed in Table 1. Precision:The precision of the developed HPTLC method was expressed in terms of % relative standard deviation (% R.S.D.). The results depicted revealed high precision of the method is presented in Table 2.Repeatability: Ruggedness of the method was per-formed by applying 400ng by two different analyst keeping same experimental and environmental conditions. The % R.S.D was found to be 0.45. LOD and LOQ: Detection limit and quantification limit was calculated by the method as described in Specificity. The LOQ and LOD were 24.13ng and 63.83ng. This indicates that adequate sensitivity of the method. Robustness:The standard deviation of peak areas was calculated for each parameter and % R.S.D. was found to be less than 2 %. Accuracy:The proposed method when used for extraction and subsequent estimation of both the drug from pharmaceutical dosage forms after over spotting with 80, 100 and 120 % of additional drug; afforded recovery of 98.2 -99.63 % as listed in Table 3. Paramaters 6-GingerolLinearity range (ng/spot) 150-900Calibration curve equation y = 4.103x + 398.6Correlation coefficient 0.9981

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Section: Introductionmentioning

confidence: 99%

Development and Validation of a Method for Densitometric Analysis of 6-Gingerol in Herbal extracts and Polyherbal Formulation

Jain¹,

Tatiya²,

Bagul³

2011

J Anal Bioanal Techniques

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“…1994;Mansuy et al, 1986), and act as hydroxyl radical scavengers (Taira et al, 1992). Because eugenol and isoeugenol inhibit arachidonic acid-induced thromboxane B2, they are extensively used as anti-in¯ammatory compounds (Naidu, 1995;Sharma et al, 1994). Besides their antiin¯ammatory property, anethole and its analogues exhibit chemopreventive activities as indicated by suppression of the incidence and multiplicity of both invasive and noninvasive adenocarcinomas (Reddy et al, 1993;Reddy, 1996Reddy, , 1997Lubert et al, 1997;AlHarbi et al, 1995).…”

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confidence: 99%

Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-κB, AP-1, JNK, MAPKK and apoptosis

et al. 2000

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“…Studies with other plant species have been reported, such as Benencia et al (2000), who identified dosedependent immunosuppressive activity in an extract from Trichilia glabra, which displays anti-viral, antiinflammatory and anti rheumatic properties. Sharma et al (1994) detected an immunostimulatory potential in extracts from leaves of Picrorhiza kurroa, used for anti-inflammatory, anti-arthritis, gastrointestinal and urinary disorders. Tiwari et al (2004) also detected immunostimulatory activity in an aqueous extract of Tridax procumbens (used for its anti-inflammatory, antimicrobial and hepatoprotectible properties).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the immunotoxicological effects of Dimorphandra mollis Benth., Fabaceae, in rats

Feres¹,

Toledo²,

Tagliati³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Avaliação dos efetos imunotoxicológicos de Dimorphandra mollis Benth., Fabaceae, em ratos". A Dimorphandra mollis Benth., Fabaceae, conhecida como faveira ou favad´anta, é uma planta comum do cerrado central do Brasil, muito utilizada por suas propriedades antioxidante, antiplaquetária e, principalmente, como vasoprotetora. Seu principal marcador é a rutina. Este estudo teve como objetivo avaliar a segurança da utilização do extrato seco de D. mollis em roedores. O extrato foi extraído, padronizado e quantificado apresentando teor de 76,0±3% de rutina. Nos parâmetros bioquímicos e hematológicos avaliados, não se observou alterações nos grupos de machos e fêmeas que receberam a dose de 1000 e 2000 mg/kg de D. mollis, mas observou-se um aumento de eosinófilos. Nos estudos histopatológicos detectou-se hiperreatividade da polpa branca esplênica, no grupo que recebeu a dose de 2000 mg/kg de D. mollis. Na avaliação da resposta linfoproliferativa, com 1000 e 2000 mg/kg não foram observadas alterações, e somente nos estudos com a dose de 2000 mg/kg se observou diminuição de IgG. Os resultados obtidos, utilizando roedores, sugerem que nenhuma toxicidade existe na administração de extrato seco de D. mollis na dose de 1000 mg/kg. Unitermos: Dimorphandra mollis, rutina, imunotoxicologia, roedores.ABSTRACT: Dimorphandra mollis Benth., Fabaceae, also known as "faveira" or "fava-d´anta", is a plant common to the central woodsy meadow region of Brazil. It is well known for its antioxidant, antiplatelet and, principally, vasoprotective properties. Its principal component is rutin. The objective of this study is the evaluation of the safety of the use of the dried D. mollis extract in rodents. The rutin content of the standardized extract was 76.0±3%. With respect to the biochemical and hematological parameters evaluated, no alterations in the groups of rats that received 1000 and 2000 mg/kg doses of D. mollis were observed, but an increase in eosinophiles occurred. Hyperactivity of the white splenic pulp was detected in the group that received the 2000 mg/kg dose of D. mollis. In the evaluation of the lymphproliferative response with 1000 and 2000 mg/kg, no alterations were observed, and a decrease in IgG was only observed in the studies with a 2000 mg/kg dose. The results obtained with rodents suggest that no toxicity exists with the administration of dried D. mollis extract in a 1000 mg/kg dose.

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Suppressive Effects of Eugenol and Ginger Oil on Arthritic Rats

Cited by 118 publications

References 10 publications

Development and Validation of a Method for Densitometric Analysis of 6-Gingerol in Herbal extracts and Polyherbal Formulation

Development and Validation of a Method for Densitometric Analysis of 6-Gingerol in Herbal extracts and Polyherbal Formulation

Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-κB, AP-1, JNK, MAPKK and apoptosis

Evaluation of the immunotoxicological effects of Dimorphandra mollis Benth., Fabaceae, in rats

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