Suppressive effects of Houttuynia cordata Thunb (Saururaceae) extract on Th2 immune response

Lee, Ji-Sook; Kim, In Sik; Kim, Joohwan; Kim, Jin Sook; Kim, Dong‐Hee; Yun, Chi‐Young

doi:10.1016/j.jep.2008.01.013

Cited by 56 publications

(44 citation statements)

References 24 publications

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“…(Saururaceae) is a perennial herb native to Southeast Asia with immense medicinal values. Traditionally, H. cordata is used for diuresis, detoxification, anti-viral, anti-bacterial, antileukemic, allergies, anaphylaxis and to tackle severe acute respiratory syndrome (Lai et al, 2010;Li et al, 2005;Lau et al, 2008;Lee et al, 2008). Recently, we reported that the ethanol fraction of H. cordata ethyl acetate (HC-EA) possess strong anti-oxidant and anti-neuroinflammatory properties (Park et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Houttuynia cordataalleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats

Kang

Koppula

2014

Pharmaceutical Biology

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Context: Houttuynia cordata Thunb. (Saururaceae) is used traditionally in Asian countries to treat various disease symptoms. Objective: To study the effect of H. cordata ethyl acetate (HC-EA) extract on high-fat diet (HFD)-induced hepatic steatosis. Materials and methods: HFD fed rats were orally dosed with HC-EA (100, 200, or 300 mg/kg) once daily for 8 weeks and the lipid profiles and protein expressions in hepatocytes were evaluated. Results: HFD rats showed an increase (p50.05) in the plasma lipid levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), free fatty acids (FFAs), and reduced the high-density lipoprotein (HDL) levels. Treatment with HC-EA extract (300 mg/kg) restored the changes in plasma lipid levels of TC, TG, LDL, FFA, and HDL in HFD-fed rats by 34.8, 31.1, 51.4, 32.4, and 56.3%, respectively, compared with control rats (p50.01). HC-EA treatment also decreased the hepatic lipid accumulation (p50.001 at 300 mg/kg) and improved hepatic histological lesions. HC-EA extract enhanced AMPK phosphorylation and its primary downstream targeting enzyme, acetyl-CoA carboxylase (ACC), up-regulated the gene expression of carnitine palmitoyl transferase-1 (CPT-1), and down-regulated sterol regulatory element binding protein 1, fatty acid synthase, and glutamate pyruvate transaminase protein levels in the livers of HFD-fed rats. Further, the increased expression of hepatic cytochrome P450 (CYP) composition such as CYP2E1 and CYP4A was also suppressed. Discussion and conclusion: Data suggest that HC-EA extract might act by regulating the AMPK-dependent pathway and related mediators and might be used in treating obesity-related liver diseases.

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Section: Introductionmentioning

confidence: 99%

Houttuynia cordataalleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats

Kang

Koppula

2014

Pharmaceutical Biology

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“…Recent studies have shown that anti-oxidant and antiinflammatory agents may suppress microglial activation and thus protect neuronal cell death [13,14]. H. cordata, a traditional plant is used as folk medicine for treating several diseases including allergic inflammation and anaphylaxis [4][5][6]. However, not much is known about the antineuroinflammatory activities of H. cordata extract in activated BV-2 microglial cells in vitro .…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, H. cordata is used in folk medicine for diuresis and detoxification, as well as an antiviral, anti-bacterial and anti-leukemic agent [4]. It is also known to be promisingly effective drug for allergic inflammation [5] and anaphylaxis [6]. Recently, it was used to tackle severe acute respiratory syndrome (SARS) as it is conventionally used to treat pneumonia [7].…”

Section: Introductionmentioning

confidence: 99%

Anti-Neuroinflammatory Effects of <i>Houttuynia cordata</i> Extract on LPS-Stimulated BV-2 Microglia

Park¹,

Koppula²,

Jung³

et al. 2013

Trop. J. Pharm Res

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Purpose: To evaluate the anti-neuroinflammatory effects of Houttuynia cordata extract (H. cordata) in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells, and its anti-oxidant properties. Methods: Anti-oxidant properties were evaluated by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay. Cell viability was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. LPS was used to stimulate BV-2 cells. Nitric oxide (NO) levels were measured using Griess assay. Inducible NO synthase (iNOS) expression, interleukin (IL)-6 expressional level were determined by enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. Results: Ethyl actetae (HC-EA) extract of H. cordata significantly scavenged DPPH free radicals in a concentration-dependent fashion. The increased levels of NO, iNOS and IL-6 in LPS-

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“…It is called E-Sung-Cho in China and it is known to be an effective drug for treating allergic inflammation (19). Previous studies concluded that the HCT is effective for treating anaphylaxis, cancer and viral infection (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells

Tang

Yang²,

Lin³

et al. 2009

Oncol Rep

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Abstract. The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anticancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell line HT-29. HCT inhibited HT-29 cell viability in a dose-and time-dependent manner by MTT assay. Treatment with 450 μg/ml of HCT for 48 and 72 h led to DNA damage and apoptosis by DAPI staining and comet assay. HCT increased reactive oxygen species production and decreased the levels of mitochondria membrane potential (MMP) in HT-29 cells by flow cytometry analysis. HCT caused the release of cytochrome c, Apaf-1, pro-caspase-9 and AIF from mitochondria via a decrease of the MMP. The decrease of MMP was then associated with a decrease in the ratio of Bax/Bcl-2 and activation of caspase-9 and -3 by Western blotting and caspase activity assay. Caspase-9 and -3 inhibitors almost completely suppressed HCT-induced caspase-9 and -3 activities. Our results demonstrated that the HCT-induced apoptosis in human colon adeno-carcinoma cell line HT-29 might be related to a mitochondrial-dependent pathway.

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Suppressive effects of Houttuynia cordata Thunb (Saururaceae) extract on Th2 immune response

Cited by 56 publications

References 24 publications

Houttuynia cordataalleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats

Houttuynia cordataalleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats

Anti-Neuroinflammatory Effects of <i>Houttuynia cordata</i> Extract on LPS-Stimulated BV-2 Microglia

Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells

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